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A 21-week open-label clinical trial of pregabalin as adjunctive therapy in partial seizures at multiple centers in Mexico (PREPS Mexico)
06 February 2012
Leopoldo Rivera-Castaño, Raul Leal-Cantu, Paula Abreu, Marita Guerrero, Gabriela Davila
Summary: Purpose: To investigate the efficacy of pregabalin in the treatment of refractory partial seizures. Methods: This was a 21-week, open-label study of pregabalin (150–600mg/day) as an adjunctiv...
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Alertness network in patients with temporal lobe epilepsy: A fMRI study
06 February 2012
Jinou Zheng, Bailing Qin, Chao Dang, Wei Ye, Zirong Chen, Lu Yu
Summary: Patients with temporal lobe epilepsy (TLE) often suffer from cognitive deficits. However, it remains elusive whether the performance of TLE patients in the attentional networks test (ANT) is ...
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Non-linear classification of heart rate parameters as a biomarker for epileptogenesis
06 February 2012
Farshad Kheiri, Anatol Bragin, Jerome Jr. Engel, Joel Almajano, Eamon Winden
Summary: Purpose: To characterize a biomarker for epileptogenesis based on cardiac interbeat interval characteristics. Methods: Electrocardiograph (ECG) and electroencephalogram (EEG) signals were rec...
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Do hyperbaric oxygen-induced seizures cause brain damage?
31 January 2012
Liran Domachevsky, Chaim G. Pick, Yehuda Arieli, Nitzan Krinsky, Amir Abramovich, Mirit Eynan
Summary: It is commonly accepted that hyperbaric oxygen-induced seizures, the most severe manifestation of central nervous system oxygen toxicity, are harmless. However, this hypothesis has not been i...
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Increases in seizure latencies induced by subcutaneous docosahexaenoic acid are lost at higher doses
30 January 2012
Marc-Olivier Trépanier, Ameer Y. Taha, Rebecca L. Mantha, Flaviu A. Ciobanu, Qiudi H. Zeng, George M. Tchkhartichvili, Anthony F. Domenichiello, Richard P. Bazinet, W.M. Burnham
Summary: Docosahexaenoic acid (DHA) is a polyunsaturated fatty acid (PUFA) which has been found to have anticonvulsant properties. Our group has previously reported in a pilot study that the acute adm...
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