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Editorial Board
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CO2
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| Reviews |
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A meta-analysis of voxel-based morphometry studies on unilateral refractory temporal lobe epilepsy
24 October 2011
Summary: Purpose: To identify consistent results of voxel-based morphometry (VBM) studies in unilateral refractory temporal lobe epilepsy (TLE). Methods: Whole-brain VBM studies comparing refractory T...
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JianPeng Li,
ZhuoBo Zhang,
HuiFang Shang
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97-103
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Systems biology impact on antiepileptic drug discovery
04 November 2011
Summary: Systems biology (SB), a recent trend in bioscience research to consider the complex interactions in biological systems from a holistic perspective, sees the disease as a disturbed network of ...
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Doru Georg Margineanu
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104-115
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| Research Papers |
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The characteristics and related influencing factors of ambulatory EEGs in patients seizure-free for 3–5 years
26 December 2011
Summary: Objective: Epileptic patients have a higher relapse risk when EEGs before the initiation of anti-epileptic drug (AED) withdrawal show epileptiform activity. The purpose of this study is to as...
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Lian Wang,
Yong-Hong Liu,
Ling Wei,
Yan-Chun Deng
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116-122
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The prevalence and treatment gap of epilepsy in Tbilisi, Georgia
28 September 2011
Summary: Introduction: Data on the prevalence of epilepsy and the extent of its treatment gap are important for planning health care delivery for people with epilepsy. The prevalence of active epileps...
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Giorgi Lomidze,
Sofia Kasradze,
David Kvernadze,
Natela Okujava,
Otar Toidze,
Hanneke M. de Boer,
Tarun Dua,
Josemir W. Sander
et al.
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123-129
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Levetiracetam clinical pharmacokinetics in elderly and very elderly patients with epilepsy
26 September 2011
Summary: We aimed to compare apparent steady-state oral clearance (CL/F) of the antiepileptic drug levetiracetam (LEV) in elderly (66–80 years, n=105) and very elderly (81–96 years, n=70) vs nonelderl...
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M. Contin,
S. Mohamed,
F. Albani,
R. Riva,
A. Baruzzi
et al.
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130-134
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Chronic bilateral subthalamic stimulation after anterior callosotomy in drug-resistant epilepsy: Long-term clinical and functional outcome of two cases
03 October 2011
Summary: We explored the efficacy and safety of bilateral SubThalamic Nucleus (STN) stimulation in two subjects suffering from drug-resistant epilepsy even after anterior callosotomy. Case 1 had about...
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Marianna Capecci,
Riccardo A. Ricciuti,
Andrea Ortenzi,
Aldo Paggi,
Vasco Durazzi,
Franco Rychlicki,
Leandro Provinciali,
Massimo Scerrati,
Maria Gabriella Ceravolo
et al.
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135-139
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High incidence of pediatric idiopathic epilepsy is associated with familial and autosomal dominant disease in Eastern Newfoundland
28 September 2011
Summary: Purpose: To describe the incidence and epidemiology of pediatric idiopathic epilepsy (IE) in Newfoundland and Labrador. Methods: All children in Newfoundland and Labrador aged 0–15 years with...
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Krista Mahoney,
David Buckley,
Muhammed Alam,
Sharon Penney,
Terry-Lynn Young,
Patrick Parfrey,
Susan J. Moore
et al.
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140-147
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Interactions of pregabalin with gabapentin, levetiracetam, tiagabine and vigabatrin in the mouse maximal electroshock-induced seizure model: A type II isobolographic analysis
26 September 2011
Summary: The aim of this study was to characterize the anticonvulsant effects of pregabalin in combination with four second-generation antiepileptic drugs (i.e., gabapentin, levetiracetam, tiagabine, ...
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Jarogniew J. Luszczki,
Damian Filip,
Magdalena Florek-Luszczki
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148-156
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Root extract of Anacyclus pyrethrum ameliorates seizures, seizure-induced oxidative stress and cognitive impairment in experimental animals
13 October 2011
Summary: In Ayurveda, Anacyclus pyrethrum has been used as a brain tonic. The present study evaluates the effect of hydroalcoholic extract of A. pyrethrum (HEAP) root against seizures, seizure-induced...
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Monika Pahuja,
Jogender Mehla,
K.H. Reeta,
Sujata Joshi,
Yogendra Kumar Gupta
et al.
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157-165
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Comparison of dense array EEG with simultaneous intracranial EEG for Interictal spike detection and localization
24 October 2011
Summary: Purpose: To evaluate the clinical utility of dense array electroencephalography (dEEG) for the detection yield and localization of interictal spikes in mesial temporal lobe epilepsy. Methods:...
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Madoka Yamazaki,
Don M. Tucker,
Ayataka Fujimoto,
Tomohiro Yamazoe,
Tohru Okanishi,
Takuya Yokota,
Hideo Enoki,
Takamichi Yamamoto
et al.
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166-173
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The detection of mood and anxiety in people with epilepsy using two-phase designs: Experiences from a tertiary care centre in Oman
17 October 2011
Summary: Background: The detection of mood and anxiety disorders is of great clinical importance in patients with chronic disease but data on the occurrence of affective dysfunction is lacking among p...
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Abdullah Al-Asmi,
Atsu S.S. Dorvlo,
David T. Burke,
Sara Al-Adawi,
Asila Al-Zaabi,
Hazar A.M. Al-Zadjali,
Zena Al-Sharbati,
Samir Al-Adawi
et al.
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174-181
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Inter-session repeatability of cortical excitability measurements in patients with epilepsy
24 October 2011
Summary: Purpose: Previous studies have evaluated the inter-session variability of motor thresholds (MT), short intracortical inhibition and intracortical facilitation using paired pulse transcranial ...
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Radwa A.B. Badawy,
Graeme D. Jackson,
Samuel F. Berkovic,
Richard A.L. Macdonell
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182-186
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Similar response to anti-epileptic medications among epileptic siblings
26 October 2011
Summary: Background: When epilepsy does not respond to the initial anti-epileptic drug (AED) the subsequent search for an effective AED is predominantly a matter of trial and error, as only limited cr...
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Hasan H. Sonmezturk,
Amir M. Arain,
Juliann M. Paolicchi,
Bassel W. Abou-Khalil
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187-193
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Antiepileptic drug combinations—Have newer agents altered clinical outcomes?
10 October 2011
Summary: In 2000, 332 (20.5%) of 1617 patients registered with the Western Infirmary Epilepsy Unit required antiepileptic drug (AED) polytherapy to remain seizure-free for at least 1 year. The analysi...
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Linda J. Stephen,
Murray Forsyth,
Kevin Kelly,
Martin J. Brodie
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194-198
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A genetic epidemiological survey of idiopathic epilepsy in the Chinese Han population
13 October 2011
Summary: Background: Idiopathic epilepsy (IE) is a syndrome that comprises epilepsy only, with no underlying structural brain lesion or other neurological signs or symptoms. Numerous studies have show...
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Ming Li,
Xueyuan Heng,
Rui Tao,
Jinsheng Liu,
Li Zhang,
Xiubin Sun,
Lifen Wang,
Qingzhong Wu,
Fengyuan Che,
Fuzhong Xue
et al.
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199-205
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The duration of sustained convulsive seizures determines the pattern of hippocampal neurogenesis and the development of spontaneous epilepsy in rats
20 October 2011
Summary: The duration of sustained seizures (SS) plays a crucial role in the occurrence of spontaneous recurrent seizures (SRS) in experimental animals. We tested whether rats with varying durations o...
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Yu-Wen Hung,
Ding-I Yang,
Pei-Yu Huang,
Tzong-Shyuan Lee,
Terry B.J. Kuo,
Chun-Hing Yiu,
Yang-Hsin Shih,
Yung-Yang Lin
et al.
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206-215
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Rats with different thresholds for DMCM-induced clonic convulsions differ in the sleep-time of diazepam and [3H]-Ro 15-4513 binding
17 October 2011
Summary: The current study investigated the possible inherent relationship between convulsions and sleep involving the GABAA/benzodiazepine site complex. The aim of this study was to determine if rats...
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Marcos Brandão Contó,
Débora Cristina Hipólide,
José Gilberto Barbosa de Carvalho,
Marco Antonio Campana Venditti
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216-222
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Association between equivalent current dipole source localization and focal cortical dysplasia in epilepsy patients
24 October 2011
Summary: We analysed the association between focal cortical dysplasia (FCD) visible in MRI and the location of equivalent current dipole (ECD) of single interictal scalp EEG spikes (IIS) in 11 epileps...
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Alejandro Blenkmann,
Gustavo Seifer,
Juan Pablo Princich,
Damian Consalvo,
Silvia Kochen,
Carlos Muravchik
et al.
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223-231
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The efficacy of topiramate in adult refractory status epilepticus: Experience of a Tertiary Care Center
17 October 2011
Summary: Refractory status epilepticus (RSE) occurs in patients with SE when they fail to respond to traditional medical therapy. Because there are very few case reports of topiramate (TPM) treatment ...
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Andrea S. Synowiec,
Kristin A. Yandora,
Vamsi Yenugadhati,
James P. Valeriano,
Carol J. Schramke,
Kevin M. Kelly
et al.
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232-237
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Synthesis and anticonvulsant evaluation of dimethylethanolamine analogues of valproic acid and its tetramethylcyclopropyl analogue
07 November 2011
Summary: Background: Valproic acid (VPA) is a major antiepileptic drug (AED) that is less potent than other AEDs. 2,2,3,3-Tetramethylcyclopropanecarboxylic acid (TMCA) is an inactive cyclopropyl analo...
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Tawfeeq Shekh-Ahmad,
Meir Bialer,
Eylon Yavin
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238-246
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| Short Communications |
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Olanzapine-associated myoclonus
26 December 2011
Summary: Olanzapine is an atypical antipsychotic drug that infrequently has been reported to cause seizures and myoclonus despite a small proconvulsant risk. This is the first report of generalized my...
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Jennifer Block Rosen,
Mark J. Milstein,
Sheryl R. Haut
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247-250
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Diffusion tensor imaging of subependymal heterotopia
26 September 2011
Summary: A magnetic resonance (MR) diffusion tensor imaging (DTI) study was performed in a newborn with bilateral subependymal heterotopia (SE). White matter fractional anisotropy (FA), axial diffusiv...
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C. Briganti,
R. Navarra,
C. Celentano,
B. Matarrelli,
A. Tartaro,
G.L. Romani,
M. Caulo
et al.
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251-254
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Memory in paediatric temporal lobe epilepsy: Effects of lesion type and side
31 October 2011
Summary: This study investigated the role of underlying pathology on memory function of children with temporal lobe epilepsy (TLE). Memory was assessed in 44 children with TLE resulting from hippocamp...
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Francesca Cormack,
Faraneh Vargha-Khadem,
Stephen J. Wood,
J. Helen Cross,
Torsten Baldeweg
et al.
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255-259
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Initial post marketing experience with lacosamide in adult patients with epilepsy
24 October 2011
Summary: The outcomes of adult epilepsy patients prescribed lacosamide for additional seizure control. Responders were defined as having at least a 50% decrease in seizure frequency Sixty-seven patien...
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Cynthia L. Harden,
Aaron Cohn,
Merredith Lowe,
Enrique Serrano
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260-263
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Aquaporin-4-dependent edema clearance following status epilepticus
14 October 2011
Summary: We investigated the role of aquaporin-4 in the development of cerebral edema following kainic acid-induced status epilepticus (SE) using specific gravimetry and T2 MRI techniques at 6h, 1 day...
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Darrin J. Lee,
Mariam Amini,
Mark J. Hamamura,
Mike S. Hsu,
Marcus M. Seldin,
Orhan Nalcioglu,
Devin K. Binder
et al.
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264-268
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Changed constitution without change in brand name – The risk of generics in epilepsy
26 October 2011
Summary: Purpose: Lamotrigine (LTG) is an anti epileptic medication (AEM) for which blood levels are helpful for optimal dosing. In late 2010, patients attending an epilepsy clinic were becoming toxic...
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Vishal Patel,
Dennis J. Cordato,
Manu Dias,
Roy G. Beran
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269-272
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Four novel and two recurrent NHLRC1 (EPM2B) and EPM2A gene mutations leading to Lafora disease in six Turkish families
02 November 2011
Summary: Lafora disease (LD) is a type of autosomal recessive, progressive myoclonus epilepsy resulting mostly from mutations in the EPM2A and NHLRC1 genes. Mutational analysis in both genes was initi...
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Seda Salar,
Naz Yeni,
Ayşegül Gündüz,
Ayşe Güler,
Ahmet Gökçay,
Sibel Velioğlu,
Aslı Gündoğdu,
S. Hande Çağlayan
et al.
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273-276
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Are patients referred for presurgical evaluation drug resistant according to the new consensus definition? A study in a tertiary center
19 December 2011
Summary: We performed a retrospective chart review of the last consecutive 40 patients admitted in our Epilepsy Unit for presurgical evaluation to find out if they met criteria for drug resistant epil...
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Mar Carreño,
Javier Aparicio,
Alba Sierra,
Azahara Aceituno,
Luis Pintor,
Nuria Bargallò,
Javier Setoain,
Jordi Rumià,
Teresa Boget,
Antonio Donaire,
Eva Bailles,
Santiago Fernández
et al.
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277-280
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| Letter to the Editor |
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Phenytoin intoxication induced by Mandrax (methaqualone)
24 October 2011
Phenytoin is most commonly prescribed drug for management of epilepsy, particularly in developing countries. Phenytoin therapy is known to cause toxic central nervous system reactions, due to its pecu...
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Rajesh Verma,
Naveen Tiwari
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281-282
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