Epilepsy Research
Volume 32, Issue 1 , Pages 172-182 , 1 September 1998

Supragranular mossy fiber sprouting is not necessary for spontaneous seizures in the intrahippocampal kainate model of epilepsy in the rat

References 

  1. Babb TL, Kupfer WR, Pretorius JK, Crandall PH, Levesque MF. Synaptic reorganization by mossy fibers in human epileptic fascia dentata. Neuroscience. 1991;42:351–363
  2. Babb TL, Pretorius JK, Kupfer W, Mathern GW, Crandall PH, Levesque MF. Aberrant synaptic reorganization in human epileptic hippocampus: evidence for feedforward excitation. Dendron. 1992;1:7–25
  3. Babb TL, Pereira-Leite J, Mathern GW, Pretorius JK. Kainic acid induced hippocampal seizures in rats: comparisons of acute and chronic seizures using intrahippocampal versus systemic injections. Ital. J. Neurol. Sci. 1995;16:39–44
  4. Babb TL, Mathern GW, Leite JP, Pretorius JK, Yeoman KW, Kuhlman PA. Glutamate AMPA receptors in the fascia dentata of human and kainate rat hippocampal epilepsy. Epilepsy Res. 1996;26:193–205
  5. Barbarosie M, Avoli M. CA3-driven hippocampal-entorhinal loop controls rather than sustains in vitro limbic seizures. J. Neurosci. 1997;17:9308–9314
  6. Bendotti C, Baldessari S, Samanin R, De Biasi S. Ultrastructural immunolocalization of GAP-43 in the sprouted mossy fibers of kainic acid lesioned rats. NeuroReport. 1994;5:2645–2648
  7. Bendotti C, Pende M, Samanin R. Expression of GAP-43 in the granule cells of the rat hippocampus after seizure-induced sprouting of mossy fibers: in situ hybridization and immunocytochemical studies. Eur J Neurosci. 1994;6:509–515
  8. Bendotti C, Pende M, Guglielmetti F, Samanin R. Cycloheximide inhibits kainic acid-induced GAP-43 mRNA in dentate granule cells in rats. NeuroReport. 1996;7:2539–2542
  9. Cavalheiro EA, Riche DA, Le Gal La Salle G. Long-term effects of intrahippocampal kainic acid injection in rats: a method for inducing spontaneous recurrent seizures. Electroencephalogr. Clin. Neurophysiol. 1982;53:581–589
  10. Cohen DR, Ferreira PCP, Gentz R, Franza RJ, Curran T. The product of a fos-related gene, fra-1, binds cooperatively to the AP-1 site with Jun: transcription factor AP-1 is comprised of multiple protein complexes. Genes Dev. 1989;3:173–184
  11. Cronin J, Dudek FE. Chronic seizures and collateral sprouting of dentate mossy fibers after kainic acid treatment in rats. Brain Res. 1988;474:181–184
  12. Cronin J, Obenaus A, Houser CR, Dudek FE. Electrophysiology of dentate granule cells after kainate-induced synaptic reorganization of mossy fibers. Brain Res. 1992;573:305–310
  13. Curran T, Franza BR. Fos and Jun: the AP1 connection. Cell. 1988;55:395–397
  14. Elmér E, Kokaia Z, Kokaia M, Lindvall O, McIntyre DC. Mossy fiber sprouting: evidence against a facilitatory role in epileptogenesis. NeuroReport. 1997;8:1193–1196
  15. Esclapez M, Hirsch JC, Agassadian C, Ben-Ari Y, Bernard C. Enhanced glutamatergic excitatory drive in the dendrites and somata of CA1 pyramidal neurons in epilepsy. Soc. Neurosci. Abst. 1997;23:2158
  16. Franck JE, Pokorny J, Kunkel DD, Schwartzkroin PA. Physiologic and morphologic characteristics of granule cell circuitry in human epileptic hippocampus. Epilepsia. 1995;36:543–558
  17. Isokawa M. Decreased time constant in hippocampal dentate granule cells in pilocarpine-treated rats with progressive seizures frequencies. Brain Res. 1996;718:169–175
  18. Isokawa M, Mello LEAM. NMDA receptor-mediated excitability in dendritically deformed dentate granule cells in pilocarpine-treated rats. Neurosci. Lett. 1991;129:69–73
  19. Isokawa M, Avanzini G, Finch DM, Babb TL, Levesque MF. Physiologic properties of human dentate granule cells in slices prepared from epileptic patients. Epilepsy Res. 1991;9:242–250
  20. Isokawa M, Levesque MF, Babb TL, Engel J. Single mossy fiber axonal systems of human dentate granule cells studied in hippocampal slices from patients with temporal lobe epilepsy. J. Neurosci. 1993;13:1511–1522
  21. Lemos T, Cavalheiro EA. Suppression of pilocarpine-induced status epilepticus and the late development of epilepsy in rats. Exp. Brain Res. 1995;102:423–428
  22. Longo BM, Mello LEAM. Blockade of pilocarpine- or kainate-induced mossy fiber sprouting by cycloheximide does not prevent subsequent epileptogenesis in rats. Neurosci. Lett. 1997;226:163–166
  23. Masukawa LM, Uruno K, Sperling MR, O’Connor MJ, Burdette LJ. The functional relationship between antidromically evoked field responses of the dentate gyrus and mossy fiber reorganization in temporal lobe epileptic patients. Brain Res. 1992;579:119–127
  24. Mathern GW, Cifuentes F, Leite JP, Pretorius JK, Babb TL. Hippocampal EEG excitability and chronic spontaneous seizures are associated with aberrant synaptic reorganization in the rat intrahippocampal kainate model., Electroencephalograph. Clin. Neurophysiol. 1993;87:326–339
  25. Mathern GW, Pretorius JK, Babb TL. Quantified patterns of mossy fiber sprouting and neuron densities in hippocampal and lesional seizures. J. Neurosurg. 1995;82:211–219
  26. Mathern GW, Babb TL, Leite JP, Pretorius JK, Yeoman KW, Kuhlman PA. The pathogenic and progressive features of chronic human hippocampal epilepsy. Epilepsy Res. 1996;26:151–161
  27. Mathern GW, Bertram III EH, Babb TL, Pretorius JK, Kuhlman PA, Spradlin S, et al. In contrast to kindled seizures, the frequency of spontaneous epilepsy in the limbic status model correlates with greater aberrant fascia dentata excitatory and inhibitory axon sprouting, and increased staining for N-methyl-d-aspartate, AMPA and GABAa receptors. Neuroscience. 1997;77:1003–1019
  28. McKinney RA, Debanne D, Gähwiler BH, Thompson SM. Lesion-induced axonal sprouting and hyperexcitability in the hippocampus in vitro: implications for the genesis of post-traumatic epilepsy. Nature Med. 1997;3:990–996
  29. McNamara RK, Routtenberg A. NMDA receptor blockade prevents kainate induction of protein F1/GAP-43 mRNA in hippocampal granule cells and subsequent mossy fiber sprouting in the rat. Mol Brain Res. 1995;33:22–28
  30. Meier CL, Dudek FE. Spontaneous and stimulation-induced synchronized afterdischarges in the isolated CA1 of kainate-treated rats. Soc. Neurosci. Abst. 1993;33:1464
  31. Okazaki MM, Nadler JV. Antidromically-evoked NMDA synaptic currents in dentate granule cells from rats with and without recurrent mossy fiber growth. Soc. Neurosci. Abst. 1997;23:2155
  32. Okazaki MM, Evenson DA, Nadler JV. Hippocampal mossy fiber sprouting and synapse formation after status epilepticus in rats: visualization after retrograde transport of biocytin. J. Comp. Neurol. 1995;352:515–534
  33. Perez Y, Morin F, Beaulieu C, Lacaille JC. Axonal sprouting of CA1 pyramidal cells in hyperexcitable hippocampal slices of kainate-treated rats. Eur. J. Neurosci. 1996;8:736–748
  34. Racine RJ. Modification of seizure activity by electrical stimulation. II. Motor seizure. Electroencephalogr. Clin. Neurophysiol. 1972;32:281–284
  35. Schreiber SS, Tocco G, Najm I, Thompson RF, Baudry M. Cycloheximide prevents kainate-induced neuronal death and c-fos expression in adult rat brain. J. Mol. Neurosci. 1993;4:149–159
  36. Sloviter RS. Possible functional consequences of synaptic reorganization in the dentate gyrus of kainate-treated rats. Neurosci. Lett. 1992;137:91–96
  37. Spencer DD, Spencer SS. Hippocampal ressections and the use of human tissue in defining temporal lobe epilepsy syndromes. Hippocampus. 1994;4:243–249
  38. Sutula T, Cascino G, Cavazos J, Parada I, Ramirez L. Mossy fiber synaptic reorganization in the epileptic human temporal lobe. Ann. Neurol. 1989;26:321–330
  39. Tauck DL, Nadler JV. Evidence of functional mossy fiber sprouting in hippocampal formation of kainic acid-treated rats. J. Neurosci. 1985;5:1016–1022
  40. Timofeeva OA, Peterson GM. Delayed development of spontaneous seizures and prolonged convulsive state in rats after massed stimulation of the anterior piriform cortex. Brain Res. 1997;754:221–238
  41. Watanabe Y, Johnson RS, Butler LS, Binder DK, Spiegelman BM, Papaioannou VE, et al. Null mutation of c-fos impairs structural and functional plasticities in the kindling model of epilepsy. J. Neurosci. 1996;16:3827–3836
  42. Weber JRM, Skene JHP. Identification of a novel repressive element that contributes to neuron-specific gene expression. J. Neurosci. 1997;17:7583–7593
  43. Weber JR, Hanes GP, Skene JHP. Promoter elements contributing to GAP-43 gene regulation in neurons. Soc. Neurosci. Abst. 1995;21:2009
  44. Wuarin J, Dudek E. Electrographic seizures and new recurrent excitatory circuits in the dentate gyrus of hippocampal slices from kainate-treated epileptic rats. J. Neurosci. 1996;16:4438–4448

PII: S0920-1211(98)00049-7

Epilepsy Research
Volume 32, Issue 1 , Pages 172-182 , 1 September 1998