Epilepsy Research
Volume 32, Issue 1 , Pages 104-113, 1 September 1998

`Dormant' inhibitory neurons: do they exist and what is their functional impact?

Department of Physiology, Neuroscience Unit, The Medical School, University of Birmingham, Edgbaston, Birmingham B15 2TT, UK

Abstract 

The concept of dormant interneurons is proving to be hard to define precisely. We argue here that the term is best used as an operational description of interneurons which are not lost from the epileptic brain, but which fail to perform adequately. We present evidence for the existence of functionally dormant interneurons in the tetanus toxin model of chronic epilepsy, and we explore the roles of a partial dormancy (and also of charge-screening) in the acute low magnesium model of epilepsy.

Keywords:  Dormant interneurons, Tetanus toxin model, Chronic epilepsy

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PII: S0920-1211(98)00044-8

Epilepsy Research
Volume 32, Issue 1 , Pages 104-113, 1 September 1998

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