Epilepsy Research
Volume 32, Issue 1 , Pages 49-62 , 1 September 1998

Altered connections between neocortical and heterotopic areas in methylazoxymethanol-treated rat

  • Claudia Colacitti

      Affiliations

    • Department of Neurophysiology, Neurological Institute `C. Besta', via Celoria 11, 20133 Milano, Italy
  • ,
  • Giulio Sancini

      Affiliations

    • Department of Neurophysiology, Neurological Institute `C. Besta', via Celoria 11, 20133 Milano, Italy
  • ,
  • Silvana Franceschetti

      Affiliations

    • Department of Neurophysiology, Neurological Institute `C. Besta', via Celoria 11, 20133 Milano, Italy
  • ,
  • Flaminio Cattabeni

      Affiliations

    • Institute of Pharmacological Sciences, University of Milan, via Balzaretti 9, Milano, Italy
  • ,
  • Giuliano Avanzini

      Affiliations

    • Department of Neurophysiology, Neurological Institute `C. Besta', via Celoria 11, 20133 Milano, Italy
  • ,
  • Roberto Spreafico

      Affiliations

    • Department of Neurophysiology, Neurological Institute `C. Besta', via Celoria 11, 20133 Milano, Italy
  • ,
  • Monica Di Luca

      Affiliations

    • Institute of Pharmacological Sciences, University of Milan, via Balzaretti 9, Milano, Italy
  • ,
  • Giorgio Battaglia

      Affiliations

    • Department of Neurophysiology, Neurological Institute `C. Besta', via Celoria 11, 20133 Milano, Italy
    • Corresponding Author InformationCorresponding author. Tel.: +39 2 2394266; fax: +39 2 70600775; e-mail: battaglia.besta@interbusiness.it

References 

  1. Aldes LD. Thalamic connectivity of rat somatic motor cortex. Brain Res. Bull. 1988;20:333–348
  2. Baraban SC, Schwartzkroin PA. Electrophysiology of CA1 pyramidal neurons in an animal model of neuronal migration disorders: prenatal methylazoxymethanol treatment. Epilepsy Res. 1995;22:145–156
  3. Baraban SC, Schwartzkroin PA. Fluorothyl seizure susceptibility in rats following prenatal methylazoxymethanol treatment. Epilepsy Res. 1996;23:189–194
  4. Barkovich AJ, Gressens P, Evrard P. Formation, maturation, and disorders of brain neocortex. Am. J. Neuroradiol. 1992;13:423–446
  5. Barkovich AJ, Guerrini R, Battaglia G, Kalifa G, N'Guyen T, Parmeggiani A, et al. Band heterotopia: correlation of outcome with Magnetic Resonance Imaging parameters. Ann. Neurol. 1994;36:609–617
  6. Barth PG. Disorders of neuronal migration. Can. J. Neurol. Sci. 1987;14:1–16
  7. Battaglia G, Arcelli P, Granata T, Selvaggio MT, Andermann F, Dubeau F, et al. Neuronal migration disorders and epilepsy: a morphological analysis of three surgically treated patients. Epilepsy Res. 1996;26:49–58
  8. Battaglia G, Granata T, Farina L, D'Incerti L, Franceschetti S, Avanzini G. Periventricular nodular heterotopia: epileptogenic findings. Epilepsia. 1997;38:1173–1182
  9. Cattabeni F, Di Luca M. Developmental models of brain dysfunctions induced by targeted cellular ablations with methylazoxymethanol. Physiol. Rev. 1997;77:199–215
  10. Cattaneo E, Reinach B, Caputi A, Cattabeni F, Di Luca M. Selective in vitro blockade of neuroepithelial cells proliferation by methylazoxymethanol, a molecule capable of inducing long lasting functional impaiments. J. Neurosci. Res. 1995;41:640–647
  11. Colacitti C, Frassoni C, Spreafico R, Di Luca M, Caputi A, Cattabeni F, et al. Structural brain abnormalities in methylazoxymethanol treated rats: an immunocytochemical study. Eur. J. Neurosci. Suppl. 1996;9:53
  12. Collier PA, Ashwell KW. Distribution of neuronal heterotopiae following prenatal exposure to methylazoxymethanol. Neurotoxicol. Teratol. 1993;15:439–444
  13. Dambska M, Haddad R, Kozlowski PB, Lee MH, Shek J. Telencephalic cytoarchitectonics in the brains of rats with graded degrees of micrencephaly. Acta Neuropathol. 1982;58:203–209
  14. D'arcangelo G, Miao GG, Chen SC, Soares HD, Morgan JI, Curran T. A protein related to extracellular matrix proteins deleted in the mouse mutant reeler. Nature. 1995;374:719–723
  15. Di Luca M, Caputi A, Cinquanta M, Cimino M, Marini P, Princivalle A, et al. Changes in protein kinase C and in its presynaptic substrate B-50/GAP-43 after intrauterine exposure to methylazoxymethanol, a treatment inducing cortical and hippocampal damage and cognitive deficit in rats. Eur. J. Neurosci. 1995;7:899–906
  16. Dubeau F, Tampieri D, Lee N, Andermann E, Carpenter S, Leblanc R, et al. Periventricular and subcortical nodular heterotopia. A study of 33 patients. Brain. 1995;118:1273–1287
  17. Ferrer I, Alcántara S, Zújar MJ, Cinós C. Structure and pathogenesis of cortical nodules induced by prenatal X-irradiation in the rat. Acta Neuropathol. 1993;85:205–212
  18. Germano IM, Zhang YF, Sperber EF, Moshé SL. Neuronal migration disorders increase susceptibility to hyperthermia-induced seizures in developing rats. Epilepsia. 1996;37:902–910
  19. Granata T, Battaglia G, D'Incerti L, Franceschetti S, Spreafico R, Battino D, et al. Schizencephaly: neuroradiologic and epileptologic findings. Epilepsia. 1996;37:1185–1193
  20. Hicks SP, D'Amato CJ. Cell migration to the isocortex in the rat. Anat. Rec. 1968;160:619–634
  21. Jacobs KM, Gutnick MJ, Prince DA. Hyperexcitability in a model of cortical maldevelopment. Cerebral Cortex. 1996;6:514–523
  22. Johnston MV, Coyle JT. Histological and neurochemical effects of fetal treatment with methylazoxymethanol on rat neocortex in adulthood. Brain Res. 1979;170:135–155
  23. Jones EG, Valentino KL. Fleishman, Jr. J.W. Adjustment of connectivity in rat neocortex after prenatal destruction of precursor cells of layers II–IV. Dev. Brain Res. 1982;2:425–431
  24. Lee KS, Schottler F, Collins JL, Lanzino G, Couture Rao A, Hiramatsu K, et al. A genetic animal model of human neocortical heterotopia associated with seizures. J. Neurosci. 1997;17:6236–6242
  25. Mischel PS, Nguyen LP, Vinters HV. Cerebral cortical dysplasia associated with pediatric epilepsy. Review of neuropathologic features and proposal for a grading system. J. Neuropathol. Exp. Neurol. 1995;54:137–153
  26. Molinari M, Minciacchi D, Bentivoglio M, Macchi G. Efferent fibers from the motor cortex terminate bilaterally in the thalamus of rats and cats. Exp. Brain Res. 1985;57:305–312
  27. Palmini A, Gambardella A, Andermann F, Dubeau F, da Costa JC, Olivier A, et al. Intrinsic epileptogenicity of human dysplastic cortex as suggested by corticography and surgical results. Ann. Neurol. 1995;37:476–487
  28. Ramakers MJ, Urban IJA, De Graan PNE, Di Luca M, Cattabeni F, Gispen WH. The impaired long-term potentiation in the CA1 field of the hippocampus of cognitive deficient microencephalic rats is restored by d-serine. Neuroscience. 1993;54:49–60
  29. Raymond AA, Fish DR, Sisodiya SM, Alsanjari N, Stevens JM, Shorvon SD. Abnormalities of gyration, heterotopias, tuberous sclerosis, focal cortical dysplasia, microdysgenesis, dysembrioplastic neuroepithelial tumour and dysgenesis of the archicortex in epilepsy. Clinical, EEG and neuroimaging features in 100 adult patients. Brain. 1995;118:629–660
  30. Roper SN, Gilmore RL, Houser CR. Experimentally induced disorders of neuronal migration produce an increased propensity for electrographic seizures in rats. Epilepsy Res. 1995;21:205–219
  31. Sancini G, Franceschetti S, Battaglia G, Spreafico R, Di Luca M, Avanzini G. Electrophysiological recordings from methylazoxymethanol (MAM) induced heterotopic neuronal aggregates in rats. Eur. J. Neurosci. Suppl. 1996;9:53
  32. Singh SC. Ectopic neurones in the hippocampus of the postnatal rat exposed in utero to methylazoxymethanol during foetal development. Acta Neuropathol. 1977;40:111–116
  33. Zhang LL, Collier PA, Ashwell KWS. Mechanisms in the induction of neuronal heterotopiae following prenatal cytotoxic brain damage. Neurotoxicol. Teratol. 1995;17:297–311
  34. Zilles K., 1985. The Cortex of the Rat. A Stereotaxic Atlas. Springer, Berlin.

PII: S0920-1211(98)00039-4

Epilepsy Research
Volume 32, Issue 1 , Pages 49-62 , 1 September 1998