Epilepsy Research
Volume 32, Issue 1 , Pages 34-48 , 1 September 1998

Immunocytochemical investigation on dysplastic human tissue from epileptic patients

  • Roberto Spreafico

      Affiliations

    • Department of Neurophysiology, National Neurological Institute `C. Besta', via Celoria, 11, 20133 Milano, Italy
    • Corresponding Author InformationCorresponding author. Department of Experimental Neurophysiology and Epileptology, Istituto Nazionale Neurologico `Carlo Besta', Via Celoria, 11, 20133 Milano, Italy. Tel.: +39 2 2394242; fax: +39 2 70600775; e-mail: spreafico.besta@interbusiness.it
  • ,
  • Basile Pasquier

      Affiliations

    • Department of Neuropathology and Department of Neurosurgery, CHU, INSERM-U318, Grenoble, France
  • ,
  • Lorella Minotti

      Affiliations

    • Department of Neuropathology and Department of Neurosurgery, CHU, INSERM-U318, Grenoble, France
  • ,
  • Rita Garbelli

      Affiliations

    • Department of Neurophysiology, National Neurological Institute `C. Besta', via Celoria, 11, 20133 Milano, Italy
  • ,
  • Philippe Kahane

      Affiliations

    • Department of Neuropathology and Department of Neurosurgery, CHU, INSERM-U318, Grenoble, France
  • ,
  • Sylvie Grand

      Affiliations

    • Department of Neuropathology and Department of Neurosurgery, CHU, INSERM-U318, Grenoble, France
  • ,
  • Alim L Benabid

      Affiliations

    • Department of Neuropathology and Department of Neurosurgery, CHU, INSERM-U318, Grenoble, France
  • ,
  • Laura Tassi

      Affiliations

    • Department of Epilepsy Surgery, Niguarda Hospital, Milano, Italy
  • ,
  • Giuliano Avanzini

      Affiliations

    • Department of Neurophysiology, National Neurological Institute `C. Besta', via Celoria, 11, 20133 Milano, Italy
  • ,
  • Giorgio Battaglia

      Affiliations

    • Department of Neurophysiology, National Neurological Institute `C. Besta', via Celoria, 11, 20133 Milano, Italy
  • ,
  • Claudio Munari

      Affiliations

    • Department of Epilepsy Surgery, Niguarda Hospital, Milano, Italy
    • Department of Neurosurgery, University of Genova, Genova, Italy

References 

  1. Barkovich AJ, Chuang SH, Norman D. MR of neuronal migration anomalies. Am. J. Neuroradiol. 1987;8:1009–1017
  2. Barth PG. Disorders of neuronal migration. Can. J. Neurol. Sci. 1987;14:1–16
  3. Battaglia G, Arcelli P, Granata T, Selvaggio M, Andermann F, Dubeau F, et al. Neuronal migration disorders and epilepsy: a morphological analysis of three surgically treated patients. Epilepsy Res. 1996;26:49–58
  4. Battaglia G, Colacitti C, Di Luca M, Caputi A, Frassoni C, Cattabeni F, et al. Structural brain abnormalities in methylazoxymethanol treated rats: an animal model for human developmental dysgeneses. Soc. Neurosci. Abstr. 1996;22:2085
  5. Battaglia G, Granata T, Farina L, D'Incerti L, Franceschetti S, Avanzini G. Periventricular nodular heterotopia: epileptogenic findings. Epilepsia. 1997;38:1173–1182
  6. Blümcke I, Hof PR, Morrison JH, Celio MR. Distribution of parvalbumin immunoreactivity in the visual cortex of old world monkeys and humans. J. Comp. Neurol. 1990;301:417–432
  7. Brodtkorb E, Nilsen G, Smevik O, Rinck PA. Epilepsy and anomalies of neuronal migration: MRI and clinical aspects. Acta Neurol. Scand. 1992;86:24–32
  8. Crino PB, Trojanowski JQ, Eberwine J. Internexin, MAP1B, and nestin in cortical dysplasia as markers of developmental maturity. Acta Neuropathol. 1997;93:619–627
  9. DeFelipe J, Huntley GW, del Rio MR, Sola RG, Morrison JH. Microzonal decreases in the immunostaining for non-NMDA ionotropic excitatory amino acid receptor subunits GluR 2/3 and GluR5/6/7 in the human epileptogenic neocortex. Brain Res. 1994;657:150–158
  10. Dubeau F, Tampieri D, Lee N, Andermann E, Carpenter S, Leblanc R, et al. Periventricular and subcortical nodular heterotopia. A study of 33 patients. Brain. 1995;118:1273–1287
  11. Dubeau, F., Tampieri, D., Andermann, E., Lee, N., Radtke, R., Carpenter, S., Leblanc, R., Villemure, J.G., Olivier, A., Andermann, F., 1996. Periventricular and subcortical nodular heterotopia: comparison of clinical findings and results of surgical treatment. In: Guerrini, R., Andermann, F., Canapicchi, R., Roger, J., Zifkin, B.G., Pfanner, P. (Eds.), Dysplasias of Cerebral Cortex and Epilepsy. Lippincott-Raven, Philadelphia, pp. 395–406.
  12. Duong T, De Rosa MJ, Poukens V, Vinters HV, Fisher RS. Neuronal cytoskeletal abnormalities in human cerebral cortical dysplasia. Acta Neuropathol. 1994;87:493–503
  13. Engel, J. Jr., 1987. Outcome with respect to epileptic seizures. In: Engel, J. Jr. (Ed.), Surgical Treatment of the Epilepsies. Raven Press, New York, pp. 553–571.
  14. Farrell MA, De Rosa MJ, Curran JC, Lenard Secor D, Cornford ME, Comair YG, et al. Neuropathologic findings in cortical resections (including hemispherectomies) performed for the treatment of intractable childhood epilepsy. Acta Neuropathol. 1992;83:246–259
  15. Ferrer I, Tunon T, Soriano E, del Rio A, Iraizoz I, Fonseca M, et al. Calbindin immunoreactivity in normal human temporal neocortex. Brain Res. 1992;572:33–41
  16. Ferrer I, Oliver B, Russi A, Cassas R, Riviera R. Parvalbumin and calbindin D28K immunocytochemistry in human neocortical epileptic foci. J. Neurol. Sci. 1994;123:18–25
  17. Francione S, Kahane P, Tassi L, Hoffmann D, Durisotti C, Pasquier B, et al. Stereo-EEG of interictal and ictal electrical activity of a histologically proved heterotopic gray matter associated with partial epilepsy. Electroencephalogr. Clin. Neurophysiol. 1994;90:284–290
  18. Fried, I., Cascino, G., 1993. Lesional surgery. In: Engel, J. Jr. (Ed.), Surgical Treatment of the Epilepsies, 2nd ed. Raven Press, New York, pp. 501–509.
  19. Friede, R.L., 1989. Developmental Neuropathology, 2nd ed. Springer, New York.
  20. Glezer II, Hof PR, Morgane PJ. Calretinin-immunoreactive neurons in the primary visual cortex of dolphin and human brains. Brain Res. 1992;595:181–188
  21. Kuban KCK, Gilles FH. Human telencephalic angiogenesis. Ann. Neurol. 1985;17:539–548
  22. Leblanc R, Tampieri D, Robitaille Y, Feindel W, Andermann F. Surgical treatment of intractable epilepsy associated with schizencephaly. Neurosurgery. 1991;29:412–429
  23. Marco P, Sola RG, Pulido P, Alijarde MT, Sánchez A, Cajal SR, et al. Inhibitory neurons in the human epileptogenic temporal cortex: an immunocytochemical study. Brain. 1996;119:1327–1347
  24. Marin-Padilla M. Early vascularization of the embryonic cerebral cortex: Golgi and electron microscopic studies. J. Comp. Neurol. 1985;241:237–249
  25. Meyer G, Wahle P, Castaneyra-Perdomo A, Ferres-Torres R. Morphology of neurons in the white matter of the adult human neocortex. Exp. Brain Res. 1992;88:204–212
  26. Mischel PS, Nguyen LP, Vinters HV. Cerebral cortical dysplasia associated with pediatric epilepsy. Review of neuropathologic features and proposal for a grading system. J. Neuropathol. Exp. Neurol. 1995;54:137–153
  27. Munari, C., Bancaud, J., 1985. The role of stereo-EEG in the evaluation of partial epileptic seizures. In: Morselli, M.L., Porter, R.J. (Eds.), The Epilepsies. Butterworths, London, pp. 267–306.
  28. Munari, C., Francione, S., Kahane, P., Tassi, L., Hoffmann, D., Garrel, S., Pasquier, B., 1996. Uselfulness of stereo EEG investigations in partial epilepsy associated with cortical dysplastic lesions and grey matter heterotopia. In: Guerrini, R., Andermann, F., Canapicchi, R., Roger, J., Zifkin, B.G., Pfanner, P. (Eds.), Dysplasias of Cerebral Cortex and Epilepsy. Lippincott-Raven, Philadelphia, pp. 383–394.
  29. Norman MG, O'Kusky JR. The growth and development of microvasculature in human cerebral cortex. J. Neuropathol. Exp. Neurol. 1986;45(3):222–232
  30. Palmini A, Andermann F, Olivier A, Tampieri D, Robitaille Y, Andermann E, et al. Focal neuronal migration disorders and intractable partial epilepsy: a study of 30 patients. Ann. Neurol. 1991;30:741–749
  31. Palmini A, Andermann E, Andermann F. Prenatal events and genetic factors in epileptic patients with neuronal migration disorders. Epilepsia. 1994;35:965–973
  32. Prayson RA, Estes ML. Cortical dysplasia; a histopathologic study of 52 cases of partial lobectomy in patients with epilepsy. Human Pathol. 1995;25:493–500
  33. Preul MC, Leblanc R, Cendes F, Dubeau F, Reutens D, Spreafico R, et al. Function and organization in dysgenic cortex. Case report. J. Neurosurg. 1997;87:113–121
  34. Rakic P. Principles of neuronal cell migration. Experientia. 1990;46:882–891
  35. Robain, O., 1996. Introduction to the pathology of cerebral cortical dysplasia. In: Guerrini, R., Andermann, F., Canapicchi, R., Roger, J., Zifkin, B.G., Pfanner, P. (Eds.), Dysplasias of Cerebral Cortex and Epilepsy. Lippincott-Raven, Philadelphia, pp. 1–9.
  36. Rorke LB. A perspective: the role of disordered genetic control of neurogenesis in the pathogenesis of migration disorders. J. Neuropathol. Exp. Neurol. 1994;53(2):105–117
  37. Sidman RL, Rakic P. Neuronal migration disorders, with special reference to developing human brain: a review. Brain Res. 1973;62:1–35
  38. Spreafico, R., Battaglia, G., Arcelli, P., Andermann, F., Dubeau, F., Palmini, A., Olivier, A., Villemure, J.G., Tampieri, D., Avanzini, G., Avoli, M., 1998. Cortical dysplasia: an immunocytochemical study of three patients. Neurology 50, 27–36.
  39. Talairach J, Bancaud J, Szikla G, Bonis A, Geier S, Vedrenne C. Exploration fonctionnelle stereotaxique (SEEEG). Approche nouvelle de la neurochirurgie de l'epilepsie. Methodologie stereotaxique et resultats therapeutiques. Neuro-chirurgie. 1974;20(1):99–130
  40. Taylor DC, Falconer MA, Bruton CJ, Corsellis JAN. Focal dysplasia of the cerebral cortex in epilepsy. J. Neurol. Neurosurg. Psychiatr. 1971;34:369–387
  41. Vinters, H.V., Armstrong, D.L., Babb, T.L., Daumas-Duport, C., Robitaille, Y., Bruton, C.J., Farrell, M.A., 1993. The neuropathology of human symptomatic epilepsy. In: Engel, J. Jr. (Ed.), Surgical Treatment of the Epilepsies. Raven Press, New York, pp. 593–608.
  42. Yasumori K, Hasuo K, Nagata S, Masuda K, Fukni M. Neuronal migration anomalies causing extensive ventricular indentation. Neurosurgery. 1990;26:504–507

PII: S0920-1211(98)00038-2

Epilepsy Research
Volume 32, Issue 1 , Pages 34-48 , 1 September 1998