Epilepsy Research
Volume 32, Issue 3 , Pages 363-369 , November 1998

Selective loss of GABA neurons in area CA1 of the rat hippocampus after intraventricular kainate

  • France Morin

      Affiliations

    • Département de physiologie, Centre de recherche en sciences neurologiques, Université de Montréal, C.P. 6128, Succursale Centre-ville, Montréal, QC H3C 3J7, Canada
    • Département de pathologie, Centre de recherche en sciences neurologiques, Université de Montréal, C.P. 6128, Succursale Centre-ville, Montréal, QC H3C 3J7, Canada
  • ,
  • Clermont Beaulieu

      Affiliations

    • Département de pathologie, Centre de recherche en sciences neurologiques, Université de Montréal, C.P. 6128, Succursale Centre-ville, Montréal, QC H3C 3J7, Canada
  • ,
  • Jean-Claude Lacaille

      Affiliations

    • Département de physiologie, Centre de recherche en sciences neurologiques, Université de Montréal, C.P. 6128, Succursale Centre-ville, Montréal, QC H3C 3J7, Canada
    • Corresponding Author InformationCorresponding author.

Received 24 November 1997 ,Revised 27 February 1998 ,Accepted 29 April 1998.

References 

  1. Abercrombie M. Estimation of nuclear population from microtome sections. Anat. Rec. 1946;94:239–247
  2. Babb TL, Pretorius JK, Kupfer WR, Crandall RH. Glutamate decarboxylase-immunoreactive neurons are preserved in human epileptic hippocampus. J. Neurosci. 1989;9:2563–2574
  3. Ben-Ari Y. Limbic seizure and brain damage produced by kainic acid: mechanisms and relevance to human temporal lobe epilepsy. Neuroscience. 1985;14:375–403
  4. Best N, Mitchell J, Baimbridge KG, Wheal HV. Changes in parvalbumin-immunoreactive neurons in the rat hippocampus following a kainic acid lesion. Neurosci. Lett. 1993;155:1–6
  5. Best N, Mitchell J, Wheal HV. Ultrastructure of parvalbumin-immunoreactive neurons in the CA1 area of the rat hippocampus following a kainic acid injection. Acta Neuropathol. 1994;87:187–195
  6. Davenport CJ, Brown WJ, Babb TL. GABAergic neurons are spared after intrahippocampal kainate in the rat. Epilepsy Res. 1990;5:28–42
  7. Esclapez M, Tillakaratne NJK, Kaufman DL, Tobin AJ, Houser CR. Comparative localization of two forms of glutamic acid decarboxylase and their mRNAs in rat brain supports the concept of functional differences between the forms. J. Neurosci. 1994;14:1834–1855
  8. Franck JE, Kunkel DD, Baskin DG, Schwartzkroin PA. Inhibition in kainate-lesioned hyperexcitable hippocampi: physiologic, autoradiographic and immunocytochemical observations. J. Neurosci. 1988;8:1991–2002
  9. Houser CR, Esclapez M. Vulnerability and plasticity of the GABA system in the pilocarpine model of spontaneous recurrent seizures. Epilepsy Res. 1996;26:207–218
  10. Kaufman DL, Houser CR, Tobin AJ. Two forms of the gamma-aminobutyric acid synthetic enzyme glutamate decarboxylase have distinct intraneuronal distributions and cofactor interactions. J. Neurochem. 1991;56:720–723
  11. Lacaille J-C, Schwartzkroin PA. Stratum lacunosum-moleculare interneurons of hippocampal CA1 region: I. Intracellular response characteristics, synaptic responses, and morphology. J. Neurosci. 1988;8:1400–1410
  12. Lacaille J-C, Schwartzkroin PA. Stratum lacunosum-moleculare interneurons of hippocampal CA1 region: II. Intrasomatic and intradendritic recording of local circuit synaptic interactions. J. Neurosci. 1988;8:1411–1424
  13. Lacaille J-C, Mueller AL, Kunkel DD, Schwartzkroin PA. Local circuit interactions between oriens-alveus interneurons and CA1 pyramidal cells in hippocampal slices: electrophysiology and morphology. J. Neurosci. 1987;7:1979–1993
  14. Maccaferri G, McBain CJ. Passive propagation of LTD to stratum oriens-alveus inhibitory neurons modulates the temporoammonic input to the hippocampal CA1 region. Neuron. 1995;15:137–145
  15. Micheva KD, Beaulieu C. Neonatal sensory deprivation induces selective changes in the quantitative distribution of GABA-immunoreactive neurons in the rat barrel field cortex. J. Comp. Neurol. 1995;361:574–584
  16. Mrini A, Moukles H, Jacomy H, Bosler O, Doucet G. Efficient immunodetection of various protein antigens in glutaraldehyde-fixed brain tissue. J. Histochem. Cytochem. 1995;43:1285–1291
  17. Nadler JV. Kainic acid as a tool for the study of temporal lobe epilepsy. Life Sci. 1981;29:2031–2042
  18. O'Kusky J, Colonnier M. A laminar analysis of the number of neurons, glia, and synapses in the visual cortex (area 17) of adult macaque monkeys. J. Comp. Neurol. 1982;210:278–290
  19. Paxinos, G., Watson, C., 1986. The Rat Brain in Stereotaxic Coordinates. Academic Press, New York.
  20. Perez Y, Morin F, Beaulieu C, Lacaille J-C. Axonal sprouting of CA1 pyramidal cells in hyperexcitable hippocampal slices of kainate-treated rats. Eur. J. Neurosci. 1996;8:736–748
  21. Robbins RJ, Brines ML, Kim JH, Adrian T, deLanerolle N, Welsh S, et al. A selective loss of somatostatin in the hippocampus of patients with temporal lobe epilepsy. Ann. Neurol. 1991;29:325–332
  22. Sloviter R. Decreased hippocampal inhibition and a selective loss of interneurons in experimental epilepsy. Science. 1987;235:73–76
  23. Turner DA, Wheal HV. Excitatory synaptic potentials in kainic acid-denervated rat CA1 pyramidal neurons. J. Neurosci. 1991;11:2786–2794
  24. Williams S, Vachon P, Lacaille J-C. Monosynaptic GABA-mediated inhibitory postsynaptic potentials in CA1 pyramidal cells of hyperexcitable hippocampal slices from kainic acid-treated rats. Neuroscience. 1993;52:541–554

PII: S0920-1211(98)00033-3

Epilepsy Research
Volume 32, Issue 3 , Pages 363-369 , November 1998