Epilepsy Research
Volume 32, Issue 3 , Pages 345-355 , November 1998

Effects of new valproate derivatives on epileptiform discharges induced by pentylenetetrazole or low Mg2+ in rat entorhinal cortex-hippocampus slices

  • V. Armand

      Affiliations

    • Department of Neurophysiology, Institute of Physiology of the Charité, Humboldt University Berlin, Tucholskystr. 2, D 10117 Berlin, Germany
    • Corresponding Author InformationCorresponding author. Tel.: +49 30 28026640; fax: +49 30 28026669.
    • ,
  • J. Louvel

      Affiliations

    • INSERM U 109, 2 ter rue d'Alésia, 75014 Paris, France
    • ,
  • R. Pumain

      Affiliations

    • INSERM U 109, 2 ter rue d'Alésia, 75014 Paris, France
    • ,
  • U. Heinemann

      Affiliations

    • Department of Neurophysiology, Institute of Physiology of the Charité, Humboldt University Berlin, Tucholskystr. 2, D 10117 Berlin, Germany

Received 26 July 1997 ,Revised 13 April 1998 ,Accepted 28 April 1998.

References 

  1. Altrup U, Gerlach G, Reith H, Said MN, Speckmann E-J. Effects of valproate in a model nervous system (buccal ganglia of Helix pomatia): I. Antiepileptic actions. Epilepsia. 1992;33:743–752
  2. Anderson WW, Lewis DV, Swartzwelder HS, Wilson WA. Magnesium-free medium activates seizure-like events in the rat hippocampal slice. Brain Res. 1986;398:215–219
  3. Armand, V., Synthéses, études toxicologiques et pharmacologiques de nouveaux esters valproiques dérivés de saccharides et d'itols, Thèse, Université de Picardie, Amiens, 1994, 195 pp.
  4. Armand, V., Louvel, J., Postel, D., Pumain, R., Ronco, G. and Villa, P., 1994. Dérivés de l'acide valproı̈que etleurs applications comme médicaments, Brevet FR. 9408542, 11 July 1994, pp. 1–40.
  5. Armand V, Louvel J, Pumain R, Ronco G, Villa P. Effects of various valproic acid derivatives on low-calcium spontaneous epileptiform activity in hippocampal slices. Epilepsy Res. 1995;22:185–192
  6. Calabresi P, Mercuri NB, Stefani A, Bernardi G. Synaptic and intrinsic control of membrane excitability of neostriatal neurons. I. An in vivo analysis. J. Neurophysiol. 1990;63:651–662
  7. Chapman AG, Meldrum BS, Mendes E. Acute anticonvulsant activity of structural analogues of valproic acid and changes in brain GABA and aspartate content. Life Sci. 1983;32:2023–2031
  8. Dreier JP, Heinemann U. Late low magnesium-induced epileptiform activity in rat entorhinal cortex slices becomes insensitive to the anticonvulsant valproic acid. Neurosci. Lett. 1990;119:68–70
  9. Gloveli T, Albrecht D, Heinemann U. Properties of low Mg2+ induced epileptiform activity in rat hippocampal and entorhinal cortex slices during adolescence. Dev. Brain Res. 1995;87:145–152
  10. Heinemann U, Arens J, Dreier JP, Stabel J, Zhang CL. In vitro epileptiform activity: role of excitatory amino acids. Epilepsy Res. 1991;10:18–23
  11. Herron CE, Williamson R, Collingridge GL. A selective N-methyl-d-aspartate antagonist depresses epileptiform activity in rat hippocampal slices. Neurosci. Lett. 1985;61:255–260
  12. Köhr G, Heinemann U. Anticonvulsive properties of ketamine and 2-aminophosphonovalerate in the low magnesium epilepsy in rat hippocampal slices. Neurosci. Res. Commun. 1987;1:17–21
  13. Lambert PA, Venaud G. Use of valpromide in psychiatric therapeutics. Encephale. 1987;13:367–373
  14. Madeja M, Mußhoff U, Kuhlmann D, Speckmann E-J. Membrane currents elicited by the epileptogenic drug pentylenetetrazole in the native oocyte of Xenopus laevis. Brain Res. 1991;553:27–32
  15. Mody I, Lambert JDC, Heinemann U. Low extracellular magnesium induces epileptiform activity and spreading depression in rat hippocampal slices. J. Neurophysiol. 1987;57(3):869–888
  16. Nau H, Löscher W. Valproic acid and metabolites: pharmacological and toxicological studies. Epilepsia. 1984;25(Suppl. 1):S14–S22
  17. Pfeiffer M, Draguhn A, Meierkord H, Heinemann U. Effects of γ-aminobutyric acid (GABA) agonists and GABA uptake inhibitors on pharmacosensitive and pharmacoresistant epileptiform activity in vitro. Br. J. Pharmacol. 1996;119:569–577
  18. Piredda S, Yonekawa W, Whittingham TS, Kupferberg HJ. Potassium, pentylenetetrazole, and anticonvulsants in mouse hippocampal slices. Epilepsia. 1985;26:167–174
  19. Piredda S, Yonekawa W, Whittingham TS, Kupferberg HJ. Effects of antiepileptic drugs on pentylenetetrazole-induced activity in the in vitro hippocampus. Epilepsia. 1986;27:341–346
  20. Psarropoulou C, Matsokis N, Angelatou F, Kostopoulos G. Pentylenetetrazole-induced seizures decrease β-aminobutyric acid-mediated recurrent inhibition and enhance adenosine-mediated depression. Epilepsia. 1994;35:12–19
  21. Rogawski MA, Porter RJ. Antiepileptic drugs: Pharmacological mechanism and clinical efficacy with consideration of promising developmental stage compounds. Pharmacol. Rev. 1990;42:223–286
  22. Walther H, Lambert JDC, Jones RSG, Heinemann U, Hamon B. Epileptiform activity in combined slices of the hippocampus, subiculum and entorhinal cortex during perfusion with low magnesium medium. Neurosci. Lett. 1986;69:156–161
  23. Zhang CL, Heinemann U. Effects of the triazole derivative loreclezole (R72063) on stimulus induced ionic and field potential responses and on different patterns of epileptiform activity induced by low magnesium in rat entorhinal cortex-hippocampal slices. Naunyn Schmiedebergs Arch. Pharmacol. 1992;346:581–587
  24. Zhang CL, Dreier JP, Heinemann U. Paroxysmal epileptiform discharges in temporal lobe slices after prolonged exposure to low magnesium are resistant to clinically used anticonvulsants. Epilepsy Res. 1995;20:105–111

PII: S0920-1211(98)00030-8

Epilepsy Research
Volume 32, Issue 3 , Pages 345-355 , November 1998

Article Tools

* Image Usage & Resolution