Epilepsy Research
Volume 31, Issue 3 , Pages 187-198 , August 1998

Effects of carbamazepine on hippocampal serotonergic system

  • Motohiro Okada

      Affiliations

    • Department of Neuropsychiatry, School of Medicine, Hirosaki University, Hirosaki 036, Japan
    • Corresponding Author InformationCorresponding author. Tel.: +81 172 395066; fax: +81 172 395067; e-mail: okadamot@cc.hirosaki-u.ac.jp
    • ,
  • Takayuki Hirano

      Affiliations

    • Department of Biochemistry Research, Mianami-Hanamaki National Hospital, Hanamaki 025, Japan
    • ,
  • Kazuhisa Mizuno

      Affiliations

    • Department of Neuropsychiatry, School of Medicine, Hirosaki University, Hirosaki 036, Japan
    • ,
  • Yuko Kawata

      Affiliations

    • Department of Neuropsychiatry, School of Medicine, Hirosaki University, Hirosaki 036, Japan
    • ,
  • Kazumaru Wada

      Affiliations

    • Department of Neuropsychiatry, School of Medicine, Hirosaki University, Hirosaki 036, Japan
    • ,
  • Takuya Murakami

      Affiliations

    • Department of Neuropsychiatry, School of Medicine, Hirosaki University, Hirosaki 036, Japan
    • ,
  • Hiroichi Tasaki

      Affiliations

    • Department of Neuropsychiatry, School of Medicine, Hirosaki University, Hirosaki 036, Japan
    • ,
  • Sunano Kaneko

      Affiliations

    • Department of Neuropsychiatry, School of Medicine, Hirosaki University, Hirosaki 036, Japan

Received 17 October 1997 ,Revised 17 March 1998 ,Accepted 28 March 1998.

References 

  1. Browning, R.A., 1987. The role of neurotransmitters in electricshock seizure models. In: Jobe, P.C., Laird, H.E. II (Eds.), Neurotransmitter and Epilepsy. Humana Press, Clifton, NJ, pp. 277–320.
  2. Buus Lassen L. Potent and long-lasting potentiation of two 5-hydroxytryptophan-induced effects in mice by three selective 5-HT uptake inhibitors. Eur. J. Pharmacol. 1997;47:351–358
  3. Chaupt Y, de Montigny C, Blier P. Presynaptic and postsynaptic modifications of the serotonin system by long-term administration of antidepressant treatment. An in vivo electrophysiologic study in the rat. Neuropharmacology. 1991;5:219–229
  4. Colino A, Halliwell JV. Differential modulation of the three separate K-conductances in hippocampal CA1 neurons by serotonin. Nature. 1987;328:73–77
  5. De la Fuente JN, Mendlewicz J. Carbamazepine addition in tricyclic antidepressant-resistant unipolar depression. Biol. Psychiatry. 1992;32:369–374
  6. Dursun SM, Matthew VM, Reveley M. Toxic serotonin syndrome after fluxetine plus carbamazepine. Lancet. 1993;342:442–443
  7. Elphic M, Anderson SMP, Hallis KF, Granhame-Smith DG. Effects of carbamazepine on 5-hydroxytryptamine function in rodents. Psychopharmacology. 1990;100:49–53
  8. Fromm GH, Terrence CF, Maroon JC. Trigeminal neuralgia. Current concepts regarding etiology and pathogenesis. Arch. Neurol. 1984;41:1204–1207
  9. Glowinski J, Iversen L. Regional studies of catecholamines in the rat brain. J. Neurochem. 1966;13:665–669
  10. Hashiguti H, Nakahara D, Maruyama W, Naoi M, Ikeda T. Simultaneous determination of in vivo hydroxylation of tyrosine and tryptophan in rat striatum by microdialysis-HPLC: relationship between dopamine and serotonin biosynthesis. J. Neural Transm. 1993;93:213–223
  11. Hirano T, Kaneko S, Otani K, Kondo T, Sasa H, Fukushima Y. Mechanisms of antimanic effects of zotepine. Neuroscience. 1990;16:511–516
  12. Juergens U. Simultaneous determination of zonisamide and nine other anti-epileptic drugs and metabolites in serum. J. Chromatogr. 1987;385:233–240
  13. Kaneko S, Fukushima Y, Sato T, Hiramatsu M, Mori A. Effects of carbamazepine on catecholamine level in mouse brain. IRCS Med. Sci. 1980;9:80–81
  14. Kaneko S, Okada M, Hirano T, Otani K, Fukushima Y. Carbamazepine and zonisamide increase extracellular dopamine and serotonin levels in vitro, and carbamazepine does not antagonize adenosine effect in vitro: mechanisms of blockade of seizure spread. Jpn. J. Psychiatry Neurol. 1993;47:371–373
  15. Keck PEJ, McElroy SL, Friedman LM. Valproate and carbamazepine in the treatment of panic and posttraumatic stress disorders, withdrawal states, and behavioural dyscontrol syndromes. J. Clin. Psychopharmacol. 1992;12:36S–41S
  16. Kito M, Maehara M, Watanabe K. Antiepileptic drugs — calcium current interaction in cultured human neuroblastoma cells. Seizure. 1994;3:141–149
  17. Leander JD. Fluoxetine, a selective serotonin-uptake inhibitor, enhances the anticonvulsant effect of phenytoin, carbamazepine, and ameltolide (LY20116). Epilepsia. 1992;33:573–576
  18. Loiseau, P., Duche, B., 1995. Carbamazepine, clinical use. In: Levy, R.H., Mattson, R.H., Meldrum, B.S. (Eds.), Antiepileptic Drugs, 4th ed. Raven Press, New York, pp. 555–566.
  19. Macdonald, R.L., 1995. Carbamazepine, mechanisms of action. In: Levy, R.H., Mattson, R.H., Meldrum, B.S. (Eds.), Antiepileptic Drugs, 4th ed. Raven Press, New York, pp. 491–498.
  20. Masuda Y, Utsui Y, Shiraishi Y, Karasawa T, Yoshida K, Shimizu M. Relationships between plasma concentrations of diphenylhydantoin, phenobarbital, carbamazepine, and 3-sulfamoylmethyl-1,2-benzisoxazole (AD810), a new anticonvulsant agent, and their anticonvulsant or neurotoxic effects in experimental animals. Epilepsia. 1979;20:623–633
  21. Mizuno K, Okada M, Kaneko S, Hirano T, Tokinaga N, Chiba T, et al. Effects of zonisamide, carbamazepine and valproate on monoamine metabolism in rat striatum and hippocampus. Jpn. J. Psychiatry Neurol. 1994;48:406–408
  22. Nelson DR, Thomas DR, Johnson AM. Pharmacological effects of paroxetine after repeated administration to animals. Acta Psychiatr. Scand. 1989;80:21–23
  23. Neppe VM. Carbamazepine in the psychiatric patient. Lancet. 1982;2:334
  24. Okada M, Kaneko S, Hirano T, Ishida M, Kondo T, Otani K, et al. Effects of zonisamide on extracellular levels of monoamine and its metabolites, and on Ca2+ dependent dopamine release. Epilepsy Res. 1992;13:113–119
  25. Okada M, Kaneko S, Hirano T, Mizuno K, Kondo T, Otani K, et al. Effects of zonisamide on dopaminergic system. Epilepsy Res. 1995;22:193–205
  26. Okada M, Mizuno K, Kaneko S. Magnesium ion augmentation of inhibitory effects of adenosine on dopamine release in the rat striatum. Psychiatr. Clin. Neurosci. 1996;50:147–156
  27. Okada M, Mizuno K, Kaneko S. Adenosine A1 and A2 receptors modulate extracellular dopamine levels in rat striatum. Neurosci. Lett. 1996;212:53–56
  28. Okada M, Kiryu K, Kawata Y, Mizuno K, Wada K, Tasaki H, et al. Determination of the effects of caffeine and carbamazepine on striatal dopamine release by in vivo microdialysis. Eur. J. Pharmacol. 1997;321:181–188
  29. Okada M, Hirano T, Mizuno K, Chiba T, Kawata Y, Kiryu K, et al. Biphasic effects of carbamazepine on the dopaminergic system in rat striatum and hippocampus. Epilepsy Res. 1997;28:143–153
  30. Okada M, Kawata Y, Kiryu K, Mizuno K, Wada K, Inomata H, et al. Effects of non-toxic and toxic concentrations of phenytoin on monoamines levels in rat brain. Epilepsy Res. 1997;28:155–163
  31. Okada M, Kawata Y, Kiryu K, Wada K, Tasaki H, Kaneko S. Effects of adenosine receptor subtypes on hippocampal extracellular serotonin level and serotonin reuptake activity. J. Neurochem. 1997;69:2581–2588
  32. Okuma T, Yamashita I, Takahashi R, Itoh H, Otuki S, Watanabe S, et al. Comparison of the antimanic efficacy of carbamazepine and lithium carbanate by double-blind controlled study. Pharmacopsychiatry. 1990;23:143–150
  33. Pratt JA, Jenner P, Marsden CD. Comparison of the effects of benzodiazepines and other anticonvulsant drugs on synthesis and utilization of 5-HT in mouse brain. Neuropharmacology. 1985;24:59–68
  34. Schinder, W., 1960. New N-heterocyclic compounds, US Patent 2,948,718, August 9, 1960.
  35. Schwarz JR, Grigat G. Phenytoin and carbamazepine: potential- and frequency-dependent block of Na+ currents in mammalian myelinated nerve fibers. Epilepsia. 1989;30:286–294
  36. Sharp T, Bramwell SR, Grahame-Smith DG. Release of endogenous 5-hydroxy-tryptamine in rat ventral hippocampus evoked by electrical stimulation of the dorsal raphe nucleus as detected by microdialysis: sensitivity to tetrodotoxin, calcium and calcium antagonist. Neuroscience. 1990;39:629–637
  37. Yoshimura R, Yanagihara N, Terao T, Minami L, Abe K, Izumi F. Inhibition by carbamazepine of various ion channels — mediated catecholamine secretion in cultured bovine adrenal medullary cells. Naunyn-Schmiedeberg's Arch. Pharmacol. 1995;352:297–303
  38. Wada Y, Nakamura M, Hasegawa H, Yamaguchi N. Intra-hippocampal injection of 8-hydroxy-2(di-n-propylamino) tetralin (8-OH-DPAT) inhibits partial and generalized seizure induced by kindling stimulation in cats. Neurosci. Lett. 1993;159:179–182

PII: S0920-1211(98)00025-4

Epilepsy Research
Volume 31, Issue 3 , Pages 187-198 , August 1998

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