Epilepsy Research
Volume 31, Issue 2 , Pages 129-133 , July 1998

Elevated levels of interleukin-6 may occur in cerebrospinal fluid from patients with recent epileptic seizures

  • Jukka Peltola

      Affiliations

    • Department of Neurology, Tampere University Hospital, P.O. Box 2000, Fin-33101 Tampere, Finland
    • Medical School, University of Tampere, P.O. Box 607, Fin-33101 Tampere, Finland
    • Corresponding Author InformationCorresponding author.
    • ,
  • Mikko Hurme

      Affiliations

    • Medical School, University of Tampere, P.O. Box 607, Fin-33101 Tampere, Finland
    • ,
  • Ari Miettinen

      Affiliations

    • Department of Clinical Microbiology, Tampere University Hospital, P.O. Box 2000, Fin-33101 Tampere, Finland
    • ,
  • Tapani Keränen

      Affiliations

    • Department of Neurology, Tampere University Hospital, P.O. Box 2000, Fin-33101 Tampere, Finland
    • Medical School, University of Tampere, P.O. Box 607, Fin-33101 Tampere, Finland

Received 17 October 1997 ,Revised 17 March 1998 ,Accepted 28 March 1998.

References 

  1. Bruce AJ, Boling W, Kindy MS, Peschon J, Kraemer PH, Carpenter MK, et al. Altered neuronal and microglial responses to excitotoxic and ischemic brain injury in mice lacking TNF receptors. Nature Med. 1996;2:788–794
  2. De Bock F, Dornand J, Rondouin G. Release of TNFα in the rat hippocampus following epileptic seizures and excitotoxic neuronal damage. NeuroReport. 1996;7:1125–1129
  3. Devinsky O, Nadi S, Theodore WH, Porter RJ. Cerebrospinal fluid pleocytosis following simple, complex partial, and generalized tonic-clonic seizures. Ann Neurol. 1988;23:402–403
  4. Hopkins SJ, Rothwell NJ. Cytokines and the nervous system I: expression and recognition. Trends Neurosci. 1995;18:83–88
  5. Iivanainen M, Hietala J, Malkamäki M, Waltimo O, Valtonen VV. An association between epileptic seizures and increased serum bacterial antibody levels. Epilepsia. 1983;24:584–587
  6. McKenzie, S.B., 1996. Nonmalignant granulocyte and monocyte disorders. In: McKenzie, S.B. (Ed.), Textbook of Hematology. Williams and Wilkins, Baltimore, pp. 275-295.
  7. Minami M, Kuraishi Y, Satoh M. Effects of kainic acid on messenger RNA levels of IL-1α, IL-6, TNFα and LIF in the rat brain. Biochem Biophys Res Commun. 1991;176:593–598
  8. Minami M, Kuraishi Y, Yamaguchi T, Nakai S, Hirai Y, Satoh M. Convulsants induce interleukin-1β messenger RNA in rat brain. Biochem Biophys Res Commun. 1990;171:832–837
  9. Prasad AV, Pilcher WH, Joseph SA. Nuclear factor-kappa B in rat brain: enhanced DNA-binding activity following convulsant-induced seizures. Neurosci Lett. 1994;170:145–148
  10. Ruth RE. Increased cerebrovascular permeability to protein during systemic kainic acid seizures. Epilepsia. 1984;25:259–268
  11. St. Pierre, B.A., Merrill, J.E., Dopp, J.M., 1996. Effects of cytokines on CNS cells: glia. In: Ransohoff, R.M., Benveniste, E.N. (Eds.), Cytokines and the CNS. CRC Press, Boca Raton, FL, pp. 151–168.
  12. Yong, V.W., 1996. Cytokines, astrogliosis, and neurotrophism following CNS trauma. In: Ransohoff, R.M., Benveniste, E.N. (Eds.), Cytokines and the CNS. CRC Press, Boca Raton, FL, pp. 309–327.

PII: S0920-1211(98)00024-2

Epilepsy Research
Volume 31, Issue 2 , Pages 129-133 , July 1998

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