Epilepsy Research
Volume 31, Issue 1 , Pages 39-46 , June 1998

High-frequency stimulation of the sub-thalamic nucleus suppresses absence seizures in the rat: comparison with neurotoxic lesions

  • L Vercueil

      Affiliations

    • U398 INSERM, Faculté de Médecine, 11 rue Humann, F67085 Strasbourg, Cedex, France
    • Corresponding Author InformationCorresponding author. Tel.: +33 388 243364; fax: +33 388 243360; e-mail: depaulis@neurochem.u-strasbg.fr
  • ,
  • A Benazzouz

      Affiliations

    • U318 INSERM, Laboratoire de Neurobiophysique, Centre Hospitalier Universitaire, Grenoble, France.
  • ,
  • C Deransart

      Affiliations

    • U398 INSERM, Faculté de Médecine, 11 rue Humann, F67085 Strasbourg, Cedex, France
  • ,
  • K Bressand

      Affiliations

    • U318 INSERM, Laboratoire de Neurobiophysique, Centre Hospitalier Universitaire, Grenoble, France.
  • ,
  • C Marescaux

      Affiliations

    • U398 INSERM, Faculté de Médecine, 11 rue Humann, F67085 Strasbourg, Cedex, France
  • ,
  • A Depaulis

      Affiliations

    • U398 INSERM, Faculté de Médecine, 11 rue Humann, F67085 Strasbourg, Cedex, France
  • ,
  • A.L Benabid

      Affiliations

    • U318 INSERM, Laboratoire de Neurobiophysique, Centre Hospitalier Universitaire, Grenoble, France.

Received 20 November 1997 ,Revised 16 February 1998 ,Accepted 23 February 1998.

References 

  1. Alexander G, Crutcher M. Functional architecture of basal ganglia circuits neural substrates of parallel processing. Trends Neurosci. 1990;13:266–271
  2. Benazzouz A, Piallat B, Pollak P, Benabid AL. Responses of substantia nigra pars reticulata and globus pallidus complex to high frequency stimulation of the subthalamic nucleus in rats: electrophysiological data. Neurosci. Lett. 1995;189:77–80
  3. Blandini F, Greenamyre JT. Effect of subthalamic lesion on mitochondrial enzyme activity in rat basal ganglia. Brain Res. 1995;669:59–66
  4. Burbaud P, Gross C, Bioulac B. Effect of subthalamic high frequency stimulation on substantia nigra pars reticulata and globus pallidus neurons in normal rats. J. Physiol–Paris. 1994;88:359–361
  5. Burbaud P, Gross C, Benazzouz A, Coussemacq M, Bioulac B. Reduction of apomorphine-induced rotational behaviour by subthalamic lesion in 6-OHDA lesioned rats is associated with a normalization of firing rate and discharge pattern of pars reticulata neurons. Exp Brain Res. 1995;105:48–58
  6. Chevalier G, Vacher S, Deniau J, Desban M. Disinhibition as a basic process in the expression of striatal functions I: The striato-nigral influence on tecto-spinal–tecto-diencephalic neurons. Brain Res. 1985;334:215–226
  7. Danober L, Deransart C, Depaulis A, Vergnes M, Marescaux C. Pathophysiological mechanisms of genetic absence epilepsy in the rat. Prog. Neurobiol. 1998;54:1–31
  8. Depaulis A, Vergnes M, Liu Z, Kempf E, Marescaux C. Involvement of the nigral output pathways in the inhibitory control of the substantia nigra over generalized non-convulsive seizures in the rat. Neurosci. 1990;39:339–349
  9. Depaulis A, Vergnes M, Marescaux C. Endogenous control of epilepsy: the nigral inhibitory system. Prog. Neurobiol. 1994;42:33–52
  10. Deransart C, Marescaux C, Depaulis A. Involvement of nigral glutamatergic inputs in the control of seizures in a genetic model of absence epilepsy in the rat. Neurosci. 1996;71:721–728
  11. Deransart, C., Vercueil, L., Marescaux, C., Depaulis, A., 1998. The role of basal ganglia in the control of generalized absence seizures. Epilepsy Res. (in press).
  12. Dybdal, D., Gale, K., 1996. Anticonvulsant effects of focal inhibition of the subthalamic nucleus. Annual Meeting Soc Neurosci. vol. 22-2, Washington.
  13. Féger J, Robledo P. The effects of activation or inhibition of the subthalamic nucleus on the metabolic and electrophysiological activities within the pallidal complex and the substantia nigra in the rat. Eur. J. Neurosci. 1992;3:947–952
  14. Gale K. Mechanisms of seizure control mediated by γ aminobutyric acid: role of the substantia nigra. Fed. Proc. 1985;44:2414–2424
  15. Garant DS, Gale K. Substantia nigra-mediated anticonvulsivant actions: role of nigral output pathways. Exp. Neurol. 1987;97:143–159
  16. Iadarola MJ, Gale K. Substantia nigra: site of anti-convulsant activity mediated by γ-aminobutyric acid. Science. 1982;218:1237–1240
  17. Köhler, C., 1983. Neuronal degeneration after intracerebral injections of excitotoxins. A histological analysis of kainic acid, ibotenic acid and quinolinic acid lesions in the rat brain. MacMillan, pp. 99–111.
  18. Kornhuber J, Kim J, Kornhuber M, Kornhuber H. The cortico-nigral projection: reduced glutamate content in the substantia nigra following frontal cortex ablation in the rat. Brain Res. 1984;322:124–126
  19. Le Gal La Salle G, Kajima M, Feldblum S. Abortive amygdaloid kindled seizures following microinjection of γ-vinyl-GABA in the vicinity of substantial nigra in rats. Neurosci. Lett. 1983;36:69–74
  20. Levy, R., Hazrati, L.-N., Vila, M., Hassani, O.-K., Mouroux, M., Ruberg, M., Asensi, H., Agid, Y., Féger, J., Obeso, J.A., Parent, A., Hirsch, E.C., 1997. Re-evaluation of the functional anatomy of the basal ganglia in normal and parkinsonian states. Neuroscience 76, 335–343.
  21. Limousin P, Pollak P, Benazzouz A, Hoffmann D, Le Bas JF, Broussolle E, et al. Effect on parkinsonian signs and symptoms of bilateral subthalamic nucleus stimulation. Lancet. 1995;345:91–95
  22. Limousin P, Pollak P, Hoffmann D, Benazzouz A, Perret J, Benabid A. Abnormal involuntary movements induced by subthalamic nucleus stimulation in parkinsonian patients. Movement Disorders. 1996;11:231–235
  23. Marescaux C, Vergnes M, Depaulis A. Genetic absence epilepsy in rats from strasbourg—a review. J. Neural. Transm. 1992;Suppl. 35:37–70
  24. Oertel WH, Schmechel DE, Brownstein MJ, Tappaz ML, Ransom DH, Kopin IJ. Decrease of glutamate decarboxylase (GAD)-immunoreactive nerve terminals in the substantia nigra after kainic acid lesion of striatum. J. Histochem. Cytochem. 1981;29:977–980
  25. Paxinos, G., Watson, C., 1986. The Rat Brain in Stereotaxic Coordinates, 2nd ed. Academic Press, San Diego.
  26. Piallat B, Benazzouz A, Benabid AL. Subthalamic nucleus lesion in rats prevents dopaminergic nigral neuron degeneration after striatal 6-OHDA injection: behavioural and immunohistochemical studies. Eur. J. Neurosci. 1996;8:1408–1414
  27. Pollak P, Benabid AL, Gross CH, Gao DM, Laurent A, Benazzouz A, et al. Effets de la stimulation du noyau sous-thalamique dans la maladie de Parkinson. Rev Neurol–Paris. 1993;149:175–176
  28. Price RH, Hollingsworth Z, Young AB, Penney JB. Excitatory amino acid receptor regulation after subthalamic nucleus lesion in the rat. Brain Res. 1993;602:157–160
  29. Siegel, S., 1956. Nonparametric statistics for the behavioural sciences. McGraw-Hill, Kogakusha.
  30. Veliskova J, Velsek L, Moshe SL. Subthalamic nucleus: a new anticonvulsant site in the brain. Neuroreport. 1996;7:1786–1788

PII: S0920-1211(98)00011-4

Epilepsy Research
Volume 31, Issue 1 , Pages 39-46 , June 1998