Epilepsy Research
Volume 30, Issue 3 , Pages 195-202 , May 1998

Evaluation of the anticonvulsant profile of progesterone in male amygdala-kindled rats

Received 18 August 1997 ,Revised 12 December 1997 ,Accepted 21 December 1997.

References 

  1. Backstrom T, Zetterlund B, Blom S, Romano M. Effects of continuous progesterone infusion on the epileptic discharge frequency in women with partial epilepsy. Acta Neurol. Scand. 1984;69:240–248
  2. Belelli D, Bolger MB, Gee KW. Anticonvulsant profile of the progesterone metabolite 5α-pregnan-3α-ol-20-one. Eur. J. Pharmacol. 1989;166:325–329
  3. Bitran D, Purdy RH, Kellogg CK. Anxiolytic effect of progesterone is associated with increases in cortical allopregnanolone and GABAA receptor function.. Pharmacol. Biochem. Behav. 1993;45:423–428
  4. Blackhan A, Spencer PSJ. Response of female mice to anticonvulsants after pretreatment with sex steroids. J. Pharm. Pharmacol. 1970;22:304–305
  5. Carter RB, Wood PL, Wieland S, Hawkinson JE, Belelli D, Lambert JJ, et al. Characterization of the anticonvulsant properties of ganaxolone (CCD 1042; 3α-Hydroxy-3β-methyl-5α-pregnan-20-one), a selective high affinity, steroid modulator of the γ-aminobutyric acidA receptor. J. Pharmacol. Exp. Ther. 1997;280:1284–1295
  6. Concas A, Mostallino MC, Perra C, Lener R, Roscetti G, Barbaccia ML, et al. Functional correlation between allopregnanolone and [35S]-TBPS binding in the brain of rats exposed to isoniazid, pentylenetetrazol or stress. Br. J. Pharmacol. 1996;118:839–846
  7. Costa PJ, Bonnycastle DD. The effect of DCA, compound E, testosterone, progesterone, and ACTH in modifying ‘agene-induced’ convulsions in dogs. Arch. Int. Pharmacodyn. 1952;91:330–338
  8. Craig CR. Anticonvulsant activity of steroids: separability of anticonvulsant from hormonal effects. J. Pharmacol. Exp. Ther. 1966;153:337–343
  9. Deraedt R, Bonnat C, Busigny M, Chatelet P, Cousty C, Mouren M, et al. Pharmacokinetics of RU 486. In:  Beaulieu EE,  Segal SJ editor. The Antiprogestin Steroid RU 486 and Human Fertility Control. London: Plenum; 1985;p. 103–122
  10. Gevorkyan ES, Nazaryan KB, Kostanyan AA. Modifying effect of estradiol and progesterone on epileptic activity of the rat brain. Neurosci. Behav. Physiol. 1989;19:412–415
  11. Gordon GS. Hormones and metabolism, influence of steroids on cerebral metabolism in man. Recent Prog. Horm. Res. 1956;12:153
  12. Gyermek L, Iriarte J, Crabble P. Structure-activity relationship of some steroidal hypnotic agents. J. Med. Chem. 1968;11:117–125
  13. Herzog AG. Intermittent progesterone therapy and frequency of complex partial seizures in women with menstrual disorders. Neurology. 1986;36:1607–1610
  14. Holmes GL, Weber DA. The effect of progesterone on kindling: a developmental study. Dev. Brain Res. 1984;16:45–53
  15. Korneyev, A., Guidotti, A., Costa, E., 1993. Inhibition of 5α reductase suppresses progesterone induced anesthesia by blocking the accumulation of brain allopregnanolone, Soc. Neurosci. Abstr., 632–710.
  16. Kuhl DE, Engel J, Phelps M, Selin C. Epileptic pattern of local cerebral metabolism and perfusion in humans determined by emmission computerized tomography of 18F-DG and 13NH3. Ann. Neurol. 1980;8:348–360
  17. Lambert JJ, Belelli D, Hill-Vening C, Peters JA. Neurosteroids and GABAA receptor function. Trends Pharmacol. Sci. 1995;16:295–303
  18. Landgren S, Backstrom T, Kalistratov G. The effect of progesterone on the spontaneous interictal spike evoked by the application of penicillin to the cat’s cerebral cortex. J. Neurol. Sci. 1978;36:119–123
  19. Landgren S, Aasly J, Backstrom T, Dubrovsky B, Danielsson E. The effect of progesterone and its metabolites on the interictal epileptiform discharge in the cat's cerebral cortex. Acta Physiol. Scand. 1987;131:33–42
  20. Majewska MD. Neurosteroids: endogenous bimodal modulators of the GABAA receptor. Mechanism of action and physiological significance. Prog. Neurobiol. 1992;38:379–395
  21. Mattson RH, Klein PE, Caldwell BV, Cramer JA. Medroxyprogesterone treatment of women with uncontrolled seizures. Epilepsia. 1982;23:436–437
  22. Mattson RH, Cramer JA, Caldwell BV, Siconolfi BC. Treatment of seizures with medroxyprogesterone acetate: Preliminary report. Neurology. 1984;34:1255–1258
  23. Mc Namara JO, Byrne MC, Dasheiff RM, Fitz JG. The kindling model of epilepsy: a review. Prog. Neurobiol. 1980;15:139–159
  24. Merryman W, Boiman R, Barnes L, Rothchild I. Progesterone ‘anesthesia’ in human subjects. J. Clin. Endocrinol. Metab. 1954;14:1567–1569
  25. Michaelis M, Quastel J. Site of action of narcotics in respiratory processes. Biochem. J. 1941;35:518–533
  26. Orchinik M, Mc Ewen BS. Novel and classical actions of neuroactive steroids. Neurotransmissions. 1993;9:1–6
  27. Paul SM, . Purdy RH. Neuroactive steroids. FASEB J. 1992;6:2311–2322
  28. Pfaf DW, Mc Ewen BS. Actions of estrogens and progestins on nerve cells. Science. 1983;219:808–814
  29. Philibert D. RU 38486: An original multifaceted antihormone in vivo. In:  Agarwal MK editors. Adrenal Steroids Antagonism. Berlin: Walter de Gruyter; 1984;p. 77–101
  30. Phillis JW, Bender AS, Marszalec W. Estradiol and progesterone potentiate adenosine’s depressant action on rat cerebral cortical neurons. Gen. Pharmacol. 1985;16:609–612
  31. Phillis JW. Potentiation of the depression by adenosine of rat cerebral cortical neurones by progestational agents. Br. J. Pharmacol. 1986;89:693–702
  32. Pourgholami MH, Mirnajafi-zadeh J, Behzadi J. Effect of intraperitoneal and intrahippocampal (CA1) 2-chloroadenosine in amygdaloid kindled rats. Brain Res. 1997;751:259–264
  33. Selye H. Antagonism between anesthetic steroid hormones and pentamethylene tetrazol (Metrazol). J. Lab. Clin. Med. 1942;27:1051–1053
  34. Spiegel E. Anticonvulsant effects of desoxycorticosterone, testosterone and progesterone. Fedn. Proc. Fedn. Am. Socs. Exp. Biol. 1943;2:47
  35. Spiegel E, Wycis H. Anticonvulsant effects of steroids. J. Lab. Clin. Med. 1945;30:947–953
  36. Stit SL, Kinnard WJ. The effect of certain progestins and estrogens on the threshold of electrically induced seizure patterns. Neurology. 1968;18:213–216
  37. Tauboll E, Lindstrom S. The effect of progesterone and its metabolite 5-α-pregnan-3-α-ol-20-one on focal epileptic seizures in the cat’s visual cortex in vivo. Epilepsy Res. 1993;14:17–30
  38. Werboff J, Hedlund L, Havlena J. Audiogenic seizures in adult male castrated rats treated with various hormones. Gen. Comp. Endocr. 1963;3:389–397
  39. Woolley DE, Timiras PS. The gonad-brain relationship: effects of female sex hormones on electroshock convulsions in the rat. Endocrinology. 1962;70:196–209
  40. Zimmerman AW, Holden KR, Reiter EO, Dekaban AS. Medroxyprogesterone acetate in the treatment of seizures associated with menstruation. J. Pediatr. 1973;83:959–963

PII: S0920-1211(98)00004-7

Epilepsy Research
Volume 30, Issue 3 , Pages 195-202 , May 1998