Epilepsy Research
Volume 27, Issue 3 , Pages 165-173 , June 1997

The Neurotoxicity Scale-II: Results of a patient-based scale assessing neurotoxicity in patients with epilepsy

  • A.P Aldenkamp

      Affiliations

    • Department of Behavioral Research and Psychological Services, Epilepsy Centre, Kempenhaeghe, P.O. Box 61, 5590 AB Heeze, Netherlands
    • Corresponding Author InformationCorresponding author. Tel.: +31 4 02279022; fax: +31 4 02264924
  • ,
  • G.A Baker

      Affiliations

    • Department of Neurosciences, University of Liverpool, Walton Hospital, Liverpool, UK

Received 10 January 1996 ,Revised 17 August 1996 ,Accepted 1 February 1997.

References 

  1. Aldenkamp, A.P., Aipherts, W.C.J., Blennow, G., et al., Withdrawal of antiepileptic medication-effects on cognitive function in children-the results of the multicentre `Holmfrid' study, Neurology, 43(1) (1993) 41–51.
  2. Smith, D.B., Mattson, R.H., Cramer, J.A., et al., Results of a nationwide Veterans Administration cooperative study comparing the efficacy and toxicity of carbamazepine, phenobarbital, phenytoin and primidone, Epilepsia, 2–8 (S3) (1987) 50–58.
  3. Meador, K.J., Loring, D.E., Huh, K., et al., Comparative cognitive effects of anticonvulsants, Neurology, 40 (1990) 391–394.
  4. Amman, M.G., Werry, J.S., Paxton, J.W. et al., Effect of sodium valproate on psychomotor performance in children as a function of dose, fluctuations in concentration and diagnosis, Epilepsia, 28 (1987) 115–124.
  5. Trimble, M.R., Thompson, P.J., Sodium Valproate and cognitive function, Epilepsia, 25(S1) (1984) 60–64.
  6. Amman, M.G., Werry, J.S., Paxton, J.W. et al., Effects of carbamazepine on psychomotor performance in children as a function of drug concentration, seizure type and time of medication, Epilepsia, 31 (1990) 51–60.
  7. Gallassi, R., Morreale, A., Lorusso, S., et al. Comparison of cognitive effects in epileptic patients during monotherapy and withdrawal, Arch. Neurol., 45 (1988) 892–894.
  8. Committee on Drugs, Behavioral and cognitive effects of anticonvulsant therapy, Pediatrics 76 (1985) 644–647.
  9. Gram, L., Monitoring drug therapy and side-effects. In: M. Sillanpaa et al. (Eds.), Paediatric Epilepsy, Wrightson Biomedical Publishing, Petersfield, 1990.
  10. Aldenkamp, A.P., Cognitive side-effects of antiepileptic drugs. In: A.P. Aldenkamp, F.E. Dreifuss and W.O. Renier (Eds.), Epilepsy in Children and Adolescents, CRC-Press Publishers, Boca Raton, New York, 1995, pp. 161–183.
  11. Baker, G.A., Smith, D.F., Dewey, M., et al., The development of a seizure severity scale as an outcome measure in epilepsy, Epilepsy Res., 8 (1991) 245–251.
  12. Aldenkamp, A.P., Baker G., Pieters M.S.M., et al., The Neurotoxicity Scale; the validity of a patient-based scale, assessing neurotoxicity, Epilepsy Res., 20 (1995) 229–239.
  13. Vermeulen, J. and Aldenkamp, A.P., Cognitive Side-Effects of Chronic Antiepileptic Drug Treatment; A review of 25 years of research, Epilepsy Res., 22 (1995) 65–95.
  14. Trimble, M.R., Antiepileptic Drugs, Cognitive Function, and Behavior in Children: Evidence from recent Studies, Epilepsia, 31(54) (1990) 30–34.
  15. Parnas, J., Gram, L., Flachs, H., Psychopharmacological aspects of antiepileptic treatment, Prog. Neurobiol., 15 (1) (1980) 19–138.
  16. Aldenkamp, A.P., Vermeulen, J., Alpherts, W.C.L., et al., Validity of computerized testing: patient dysfunction and complaints versus measured changes. In: W.E. Dodson and M. Kinsbourne (Eds.), Assessment of Cognitive Function, Demos, New York, 1992, pp. 51–68.
  17. Vermeulen, J., Aldenkamp, A., Alpherts, W.C.J., Memory complaints in epilepsy: correlations with cognitive performance and neuroticism, Epilepsy Res. 15 (1993) 157–170.
  18. Cohen, I., Statistical Power Analysis for the Behavioral Sciences, Academic Press, New York, 1977.
  19. Meinardi, H., Assessment of quality of epilepsy care from child to adult; the clinimetric point of view. In: A.P. Aldenkamp, F.E. Dreifuss, W.O. Renier et al. (Eds.), Epilepsy in Children and Adolescents, CRC Press, New York, 1995, pp. 291–299.

PII: S0920-1211(97)01036-X

Epilepsy Research
Volume 27, Issue 3 , Pages 165-173 , June 1997