Epilepsy Research
Volume 27, Issue 3 , Pages 151-164 , June 1997

Felbamate and meprobamate: a comparison of their anticonvulsant properties

Received 3 September 1996 ,Revised 7 January 1997 ,Accepted 12 January 1997.

References 

  1. Adusumalli, V.E., Gilchrist, J.R., Kucharczyk, N. and Sofia, R.D., Pharmacokinetics of the new antiepileptic drug felbamate in pediatric and adult beagle dogs, Epilepsia, 33 (1992) 955–960.
  2. Bebin, E.M., Sofia, R.D. and Dreifuss, F.E., Felbamate toxicity. In: R.H. Levy, R.H. Mattson and B.S. Meldrum (Eds.), Antiepileptic Drugs, 4th Edn, Raven Press, New York, 1995, pp. 823–827.
  3. Berger, F.M., The pharmacological properties of 2-methyl-2-n-propyl-1,3-propanediol dicarbamate (Miltown), a new interneuronal blocking agent, J. Pharmacol. Exp. Ther., 112 (1954) 413–423.
  4. Berger, F.M., Handley, C.D., Ludwig, B.J. and Lynes, T.E., Central depressant and anticonvulsant activity of compounds isomeric with 2-methyl-2-n-propyl-1,3-propanediol dicarbamate (Miltown), J. Pharmacol. Exp. Ther., 116 (1956) 337–342.
  5. Boissier, J.-R., Tardy, J. and Diverres, J.-C., Une nouvelle méthode simple pour explorer l'action `tranquillisante': le test de la cheminée, Med. Exp. (Basel) 3 (1960) 81–83.
  6. Chin, L. and Swinyard, E.A., Pentylenetetrazol seizure threshold in meprobamate- and phenaglycodol-treated mice, J. Am. Pharm. Assoc. Sci. Ed., 48 (1959) 6–8.
  7. Coenen, A.M., Drinkenburg, W.H., Inoue, M. and Van Luijtelaar, E.L., Genetic models of absence epilepsy, with emphasis on the WAG/Rij strain of rats, Epilepsy Res., 12 (1992) 75–86.
  8. Dunham, N.W. and Miya, T.S., A note on a simple apparatus for detecting neurological deficit in rats and mice, J. Am. Pharm. Assoc. Sci. Ed., 46 (1957) 208–209.
  9. Fink, G.B. and Swinyard, E.A., Modification of maximal audiogenic and electroshock seizures in mice by psychopharmacologic drugs, J. Pharmacol. Exp. Ther., 127 (1959) 318–324.
  10. Frey, H.-H., Induction of seizures by air blast in gerbils: stimulus duration/effect relationship, Epilepsy Res., 1 (1987) 262–264.
  11. Frey, H.-H., Löscher, W., Reiche, R. and Schultz, D., Anticonvulsant potency of common antiepileptic drugs in the gerbil, Pharmacology, 27 (1983) 330–335.
  12. Litchfield, J.T. and Wilcoxon, R., A simplified method of evaluating dose-effect experiments, J. Pharmacol. Exp. Ther., 96 (1949) 99–113.
  13. Löscher, W. and Frey, H.-H., Evaluation of anticonvulsant drugs in gerbils with reflex epilepsy, Arzneimittel-Forsch., 34 (1984) 1484–1488.
  14. Loskota, W.J., Lomax, P. and Rich, S.T., The gerbil as a model for the study of epilepsy: seizure habituation and seizure patterns, Proc. West. Pharmacol. Soc., 15 (1972) 189–194.
  15. McNamara, J.O., Kindling: an animal model of complex partial epilepsy, Ann. Neurol., 16 (1984) S72–S76.
  16. Meyler, L. and Herxheimer, A., Side effects of drugs, Vol. VI, Exerpta Medica, Amsterdam, 1968, pp. 60.
  17. Perhach, J.L. and Shumaker, R.C., Felbamate. absorption, distribution, and excretion, In: R.H. Levy, R.H. Mattson and B.S. Meldrum (Eds.), Antiepileptic Drugs, 4th Edn, Raven Press, New York, 1995, pp. 807–812.
  18. Racine, R., Modification of seizure activity by electrical stimulation. II. Motor seizure, Electroencephalogr. Clin. Neurophysiol. 32 (1972) 295–299.
  19. Rall, T.W., Hypnotics and sedatives: ethanol. In: A. Goodman Gilman, T.W. Rall, A.S. Nies, P. Taylor (Eds.), The Pharmacological Basis of Therapeutics, 8th Edn, Pergamon Press, New York, 1990, pp. 345–382.
  20. Sofia, R.D., Felbamate. Mechanism of action. In: R.H. Levy, R.H. Mattson and B.S. Meldrum (Eds.), Antiepileptic Drugs, 4th Edn, Raven Press, New York, 1995, pp. 791–797.
  21. Swinyard, E.A., Brown, W.C. and Goodman, L.S., Comparative assays of antiepileptic drugs in mice and rats, J. Pharmacol. Exp. Ther., 106 (1952) 319–330.
  22. Swinyard, E.A., Sofia, R.D. and Kupferberg, H.J., Comparative anticonvulsant activity and neurotoxicity of felbamate and four prototype antiepileptic drugs in mice and rats, Epilepsia, 27 (1986) 27–34.
  23. Theodore, W.H., Jensen, P.K. and Kwan, R.M.F., Felbamate. Clinical use. In: R.H. Levy, R.H. Mattson and B.S. Meldrum (Eds.), Antiepileptic Drugs, 4th Edn, Raven Press, New York, 1995, pp. 817–822.
  24. Vergnes, M., Marescaux, C., Micheletti, G., Reis, J., Depaulis, A., Rumbach, L. and Warter, J.M., Spontaneous paroxysmal electroclinical patterns in the rat: a model of generalized non-convulsive epilepsy, Neurosci. Lett. 33 (1982) 97–101
  25. Voits, M. and Frey, H.-H., Stimulation-dependent effect of antiepileptic drugs in amygdala kindled rats on both seizure score and duration of afterdischarges, Pharmacol. Toxcicol., 75 (1994) 54–61.
  26. Wahle, H. and Frey, H.-H., Development of tolerance to the anticonvulsant effect of valproate but not to ethosuximide in a rat model of absence epilepsy, Eur. J. Pharmacol. 181 (1990) 1–8.
  27. White, H.S., Wolf, E.A., Swinyard, E.A., Skeen, G.A. and Sofia, R.D., A neuropharmacological evaluation of felbamate as a novel anticonvulsant, Epilepsia, 33 (1992) 564–572.
  28. Wigger, D., Der Einfluß sechs klinisch gebräuchlicher Antiepileptika auf die Krampfentwicklung und Bildung eines epileptischen Spiegelfocus im Amygdala-Kindling-Modell der Ratte. Thesis, Freie Universität Berlin, School of Veterinary Medicine, 1994

PII: S0920-1211(97)01021-8

Epilepsy Research
Volume 27, Issue 3 , Pages 151-164 , June 1997