Epilepsy Research
Volume 30, Issue 2 , Pages 159-164 , April 1998

Electrocorticographic changes during generalized convulsive status epilepticus in soman intoxicated rats1

  • Irwin Koplovitz

      Affiliations

    • Corresponding Author InformationCommander, U.S. Army Medical Research Institute of Chemical Defense, Attn: MCMR-UV-DB (Dr. I. Koplovitz), 3100 Ricketts Point Road, Aberdeen Proving Ground, MD 21010-5425, USA.
  • ,
  • John P Skvorak

Received 25 May 1997 ,Revised 10 September 1997 ,Accepted 2 December 1997.

References 

  1. Carpentier P, Foquin-Tarricone A, Bodjarian N, Rondouin G, Lerner-Natoli M, Kamenka J-M, et al. Anticonvulsant and antiethal effects of the phencyclidine derivative TCP in soman poisoning. Neurotoxicology. 1994;15:837–852
  2. Chang CWJ, Bleck TP. Status epilepticus. Neurol. Clin. 1995;13:529–548
  3. Fountain NB, Lothman EW. Pathophysiology of status epilepticus. J. Clin. Neurophysiol. 1995;12:326–342
  4. Handforth A, Ackerman RF. Hierarchy of seizure states in the electrogenic limbic status epilepticus model: behavioral and electrographic observations of initial states and temporal progression. Epilepsia. 1992;33:589–600
  5. Jope RS, Morrisett RA, Snead OC. Characterization of lithium potentiation of pilocarpine-induced status epilepticus in rats. Exp. Neurol. 1986;91:471–480
  6. Lallement G, Carpentier P, Collet A, Baubichon D, Pernot-Marino I, Blanchet G. Extracellular acetylcholine changes in rat limbic structures during soman-induced seizures. Neurotoxicology. 1992;13:557–568
  7. Lothman EW, Bertram EH. Epileptogenic effects of status epilepticus. Epilepsia. 1993;34:S59–S70
  8. McDonough JH, Shih T-M. Pharmacological modulation of soman-induced seizures. Neurosci. Biobehav. Rev. 1993;17:203–215
  9. Shih T-M, Koviak TA, Capacio BR. Anticonvulsants for poisoning by the organophoshorus compound soman: pharmacological mechanisms. Neurosci. Biobehav. Rev. 1991;15:349–362
  10. Shorvon, S., 1994. Status Epilepticus: Its Clinical Features and Treatment in Children and Adults. Cambridge University Press, Cambridge, p. 382.
  11. Sidell FR. Soman and sarin: clinical manifestations and treatment of accidental poisoning by organophosphates. Clin. Toxicol. 1974;7:1–17
  12. Solberg Y, Belkin M. The role of excitotoxicity in organophosphorous nerve agents central poisoning. Trends Pharmacol. Sci. 1997;18:183–185
  13. Taylor. P., 1996. Anticholinesterase agents. In: Hardman, J.G., Limbird, L.E. (Eds.), Goodman and Gilman's The Pharmacological Basis of Therapeutics. McGraw-Hill, New York, pp. 161–76.
  14. Treiman DM. Generalized convulsive status epilepticus in the adult. Epilepsia. 1993;34:S2–S11
  15. Treiman DM. Electroclinical features of status epilepticus. J. Clin. Neurophysiol. 1995;12:343–362
  16. Treiman DM, Walton NY, Kendrick C. A progressive sequence of electrophysical changes during generalized convulsive status epilepticus. Epilepsy Res. 1990;5:49–60
  17. Walton NY, Treiman DM. Motor and electroencephalographic response of refractory experimental status epilepticus in rats to treatment with MK-801, diazepam, or MK-801 plus diazepam. Brain Res. 1991;553:97–104

PII: S0920-1211(97)00100-9

Epilepsy Research
Volume 30, Issue 2 , Pages 159-164 , April 1998