Epilepsy Research
Volume 30, Issue 2 , Pages 153-158, April 1998

The anticonvulsant zonisamide scavenges free radicals

Department of Molecular and Cell Biology, University of California, Berkeley, CA 94720-3200, USA

Received 18 September 1997; received in revised form 24 November 1997; accepted 25 November 1997.

Abstract 

Zonisamide (ZNS) is effective in animal models of epilepsy and epileptic patients. The free radical scavenging activities of ZNS were analyzed by using electron spin resonance. ZNS, in the mmolar range, scavenged hydroxyl and nitric oxide radicals in a dose-dependent manner. This suggests that the mechanism of antiepileptic effect of ZNS may involve protection of neurons from free radical damage and stabilization of neuronal membranes.

Keywords:  Zonisamide, Antiepileptics, Free radicals, Hydroxyl radical, Nitric oxide, Electron spin resonance

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PII: S0920-1211(97)00097-1

Epilepsy Research
Volume 30, Issue 2 , Pages 153-158, April 1998

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