Epilepsy Research
Volume 30, Issue 2 , Pages 107-114 , April 1998

Regional and age specific effects of zolpidem microinfusions in the substantia nigra on seizures

  • Jana Velı́šková

      Affiliations

    • Department of Neurology, Albert Einstein College of Medicine, K 312, 1410 Pelham Parkway South, Bronx, NY 10461, USA
    • Corresponding Author InformationCorresponding author. Tel.: +1 718 4302469; fax: +1 718 4308899; e-mail: velisek@aecom.yu.edu
  • ,
  • Wolfgang Löscher

      Affiliations

    • Department of Pharmacology, Toxicology and Pharmacy, School of Veterinary Medicine, Hannover, Bünteweg 17, D-30559 Hannover, Germany
  • ,
  • Solomon L Moshé

      Affiliations

    • Department of Neurology, Albert Einstein College of Medicine, K 312, 1410 Pelham Parkway South, Bronx, NY 10461, USA
    • Department of Neuroscience, Albert Einstein College of Medicine, K 312, 1410 Pelham Parkway South, Bronx, NY 10461, USA
    • Department of Pediatrics, Albert Einstein College of Medicine, K 312, 1410 Pelham Parkway South, Bronx, NY 10461, USA

Received 1 July 1997 ,Revised 10 October 1997 ,Accepted 25 November 1997.

References 

  1. Arbilla S, Allen J, Wick A, Langer SZ. High-affinity [3H]zolpidem binding in the rat brain: an imidazopyridine with agonist properties at central benzodiazepine receptors. Eur. J. Pharmacol. 1986;130:257–263
  2. Arbilla S, Depoortere H, George P, Langer SZ. Pharmacological profile of the imidazopyridine zolpidem at benzodiazepine receptors and electrocorticogram in rats. Naunyn-Schmiedeberg's Arch. Pharmacol. 1985;330:248–251
  3. Benavides J, Peny B, Ruano D, Victorica J, Scatton B. Comparative autoradiographic distribution of central omega (benzodiazepine) modulatory site subtypes with high, intermediate, and low affinity for zolpidem and alpidem. Brain Res. 1993;604:240–250
  4. Depoortere, H., Granger, B., Avenet, P., Faure, C., Graham, D., Langer, S.Z., Scatton, B., 1994. Functional and pharmacological properties of α1β2γ2, α3β2γ2 and α5β2γ2 subtypes of GABAA receptors transiently expressed in HEK 293 cells. XII VIPHAR, Montreal, 1994.
  5. Depoortere H, Zivkovic B, Lloyd KG, Sanger DJ, Perrault G, Langer SZ, et al. Zolpidem, a novel nonbenzodiazepine hypnotic. I. neuropharmacological and behavioral effects. J. Pharmacol. Exp. Ther. 1986;237:649–658
  6. Doble A, Martin IL. Multiple benzodiazepine receptors: no reason for anxiety. Trends Pharmacol. Sci. 1992;13:76–81
  7. Duncan GE, Breese GR, Criswell HE, McCown TJ, Herbert JS, Devaud LL, et al. Distribution of [3H]zolpidem binding sites in relation to messenger RNA encoding the α1, β2 and γ2 subunits of GABAA receptors in rat brain. Neuroscience. 1995;64:1113–1128
  8. Gale K. Mechanisms of seizure control mediated by γ-aminobutyric acid: a role of the substantia nigra. Fed. Proc. Fed. Am. Soc. Exp. Biol. 1985;44:2414–2424
  9. Hajós M, Greenfield SA. Topographic heterogeneity of substantia nigra neurons: diversity in intrinsic membrane properties and synaptic inputs. Neuroscience. 1993;55:919–934
  10. Heyer EJ, Nowak LM, Macdonald RL. Bicuculline: A convulsant with synaptic and nonsynaptic actions. Neurology. 1981;31:1381–1390
  11. Hunkeler W, Möhler H, Pieri L, Polc P, Bonetti EP, Cumin R, et al. Selective antagonists of benzodiazepines. Nature. 1981;290:514–516
  12. Iadarola MJ, Gale K. Substantia nigra: site of anticonvulsant activity mediated by γ-aminobutyric acid. Science. 1982;218:1237–1240
  13. Krogsgaard-Larsen P. THIP, a specific and clinically active GABA agonist. Neuropharmacology. 1984;23:837–838
  14. Levitan ES, Blair LAC, Dionne VE, Barnard EA. Biophysical and pharmacological properties of cloned GABAA receptor subunits expressed in xenopus oocytes. Neuron. 1988;1:773–781
  15. Levitan ES, Schofield PR, Burt DR, Rhee LM, Wisden W, Köhler M, et al. Structural and functional basis for GABAA receptor heterogeneity. Nature. 1988;335:76–79
  16. Lo MMS, Niehoff DL, Kuhar MJ, Snyder SH. Differential localization of type I and type II benzodiazepine binding sites in substantia nigra. Let. Nat. 1983;306:57–60
  17. Löscher W, Schwark WS. Evidence for impaired GABA-ergic activity in the substantia nigra in amygdaloid kindled rats. Brain Res. 1985;339:146–150
  18. McCabe RT, Wamsley JK. Autoradiographic localization of subcomponents of the macromolecular GABA receptor complex. Life Sci. 1986;39:1937–1945
  19. Meldrum, B.S., 1981. GABA-agonists as antiepileptic agents. In: Costa, E. (Ed.), GABA and Benzodiazepine Receptor. Raven Press, New York, pp. 207–217.
  20. Mertens S, Benke D, Möhler H. GABAA receptor populations with novel subunit combinations and drug binding profiles identified in brain by α5- and δ-subunit-specific immunopurification. J. Biol. Chem. 1993;268:5965–5973
  21. Moshé SL, Albala BJ. Nigral muscimol infusions facilitate the development of seizures in immature rats. Dev. Brain Res. 1984;13:305–308
  22. Moshé SL, Brown LL, Kubová H, Velı́šková J, Zukin RS, Sperber EF. Maturation and segregation of brain networks that modify seizures. Brain Res. 1994;665:141–146
  23. Nicholson LFB, Faull RLM, Waldvogel HJ, Dragunow M. The regional, cellular and subcellular localization of GABAA/benzodiazepine receptors in the substantia nigra of the rat. Neuroscience. 1992;50:355–370
  24. Niemi, U.J., Redgrave, P., Westby, G.W.M., 1994. Regional variation in the effects of nigral GABA on collicular neuronal activity: implications for the role of the nigrotectal pathway. Eur. J. Neurosci. (Suppl. 7), 213.
  25. Olsen RW, McCabe RT, Wamsley JK. GABAA receptor subtypes: autoradiographic comparison of GABA, benzodiazepine, and convulsant binding sites in the rat central nervous system. J. Chem. Neuroanat. 1990;3:59–76
  26. Olsen RW, Snowhill EW, Wamsley JK. Autoradiographic localization of low affinity GABA receptors with 3H-bicuculline methochloride. Eur. J. Pharmacol. 1983;99:247–248
  27. Olsen RW, Snowhill EW, Wamsley JK. Autoradiographic localization of low affinity GABA receptors with [3H] bicuculline methochloride. Eur. J. Pharmacol. 1984;99:247–248
  28. Palacios JM, Wamsley JK, Kuhar MJ. High affinity GABA receptors-autoradiographic localization. Brain Res. 1981;222:285–330
  29. Paxinos, G., Watson, C., 1986. The rat brain in stereotaxic coordinates, second ed. Academic Press, Orlando.
  30. Pritchett DB, Seeburg PH. γ-aminobutyric acidA receptor α5-subunit creates novel type II benzodiazepine receptor pharmacology. J. Neurochem. 1990;54:1802–1804
  31. Puia G, Vicini S, Seeburg PH, Costa E. Influence of recombinant g-aminobutyric acid-A receptor subunit composition on the action of allosteric modulators of γ-aminobutyric acid-gated Cl-currents. Mol. Pharmacol. 1991;39:691–696
  32. Sanger DJ, Benavides J, Perrault G, Morel E, Cohen C, Joly D, et al. Recent developments in the behavioral pharmacology of benzodiazepine (omega) receptors: evidence for the functional significance of receptor subtypes. Neurosci. Biobehav. Rev. 1994;18:355–372
  33. Saxena NC, Macdonald RL. Properties of putative cerebellar γ-aminobutyric acid A receptor isoforms. Mol. Pharmacol. 1996;49:567–579
  34. Sigel E, Baur R, Trube G, Möhler H, Malherbe P. The effect of subunit composition of rat brain GABAA receptors on channel function. Neuron. 1990;5:703–711
  35. Sperber EF, Wong BY, Wurpel JND, Moshé SL. Nigral infusions of muscimol or bicuculline facilitate seizures in developing rats. Dev. Brain Res. 1987;37:243–250
  36. Turski L, Klockgether T, Schwartz M, Turski WA, Sontag K-H. Substantia nigra: a site of actions of muscle relaxant drugs. Ann. Neurol. 1990;28:341–348
  37. Unnerstall JR, Kuhar MJ, Niehoff DL, Palacios JM. Benzodiazepine receptors are coupled to a subpopulation of GABA receptors: Evidence from a quantitative autoradiographic study. J. Pharm. Exp. Ther. 1981;218:797–804
  38. Velı́šek L, Velı́šková J, Ptachewich Y, Ortı́z J, Shinnar S, Moshe SL. Age-dependent effects of GABA agents on flurothyl seizures. Epilepsia. 1995;36:636–643
  39. Velı́šková J, Velı́šek L, Moshé SL. Subthalamic nucleus: A new anticonvulsant site in the brain. Neuroreport. 1996;7:1786–1788
  40. Velı́šková J, Velı́šek L, Nunes M, Moshé S. Developmental regulation of regional functionality of substantia nigra GABAA receptors involved in seizures. Eur. J. Pharmacol. 1996;309:167–173
  41. Verdoorn TA, Draguhn A, Ymer S, Seeburg PH, Sakmann B. Functional properties of recombinant rat GABAA receptors depend upon subunit composition. Neuron. 1990;4:919–928
  42. Wafford K, Whiting P, Kemp J. Differences in affinity and efficacy of benzodiazepine receptor ligands at recombinant g-aminobutyric acid A receptor subtypes. Mol. Pharmacol. 1992;43:240–244
  43. Wurpel JND, Tempel A, Sperber EF, Moshé SL. Age-related changes of muscimol binding in the substantia nigra. Dev. Brain Res. 1988;43:305–308
  44. Yakushiji T, Shirasaki T, Munakata M, Hirata A, Akaike N. Differential properties of type I and type II benzodiazepine receptors in mammalian CNS neurons. Brit. J. Pharmacol. 1993;109:819–825

PII: S0920-1211(97)00096-X

Epilepsy Research
Volume 30, Issue 2 , Pages 107-114 , April 1998