Inhibition of pentylenetetrazol-induced seizures in rats by prostaglandin D₂

Abstract 

This study was undertaken to evaluate the role of brain PGD₂ activity during PTZ induced seizures in rats. Potentiation of endogenous PGD₂ activity caused an anti-convulsant effect. Thus, after PGD₂ injection (5 μg/icv) the latency of generalized tonic clonic convulsions was prolonged. ZK 118.182, a stable analogue of PGD₂, dose-dependently inhibited the incidence and the intensity of seizures when injected at doses of 1–100 ng/icv. But on the other hand, inhibition of PGD₂ activity either by a D-type PG receptor antagonist (AH 6809; 50 ng/icv) or by a PGD synthase inhibitor (sodium selenite; 0.2 μg/icv) produced a proconvulsant effect by increasing the incidence and the intensity of the seizures. These findings indicate that endogenous PGD₂ activity in the brain may have a specific inhibitory role for the initiation and propagation of PTZ induced seizures in rats.

Keywords:  PGD₂, PTZ seizure, ZK 118.182, AH 6809, Sodium selenite, Rat