Epilepsy Research
Volume 29, Issue 3 , Pages 259-264 , February 1998

Proconvulsant effects induced by pyridoxine in young rats

  • Soňa Verešová

      Affiliations

    • Department of Pathological Physiology, Third Faculty of Medicine, Charles University, Ke Karlovu 4, 120 00, Prague, Czech Republic
    • ,
  • Radka Kábová

      Affiliations

    • Department of Pathological Physiology, Third Faculty of Medicine, Charles University, Ke Karlovu 4, 120 00, Prague, Czech Republic
    • ,
  • Libor Velı́šek

      Affiliations

    • Department of Pathological Physiology, Third Faculty of Medicine, Charles University, Ke Karlovu 4, 120 00, Prague, Czech Republic
    • Department of Neurology, Albert Einstein College of Medicine, K 312, 1410 Pelham Parkway South, Bronx, NY 10461, USA
    • Corresponding Author InformationCorresponding author. Tel: +1 718 4302469; fax: +1 718 4308899; e-mail: velisek@aecom.yu.edu; http://rfyzio.lf3.cuni.cz

Received 30 June 1997 ,Revised 9 September 1997 ,Accepted 23 September 1997.

References 

  1. Bass NE, Wyllie E, Cohen B, Joseph AS. Pyridoxine-dependent epilepsy: The need for repeated pyridoxine trials and the risk of severe electrocerebral suppression with intravenous pyridoxine infusion. J. Child Neurol. 1996;11:422–424
  2. Bayley M, Walsh FM, Valaske MJ. Fatal overdose from Bendectin. Clin. Pediat. 1975;14:507–509
  3. Bender D. Vitamin B6 requirements and recommendations. Eur. J. Clin. Nutr. 1989;43:289–309
  4. Blennow G, Starck L. High dose B6 treatment in infantile spasms. Neuropediatrics. 1986;17:7–10
  5. Dordain G, Deffond D. Pyridoxine neuropathies. [Review of the literature]. Therapie. 1994;49:333–337
  6. Ebadi M, Metzler DE, Christenson WR. Convulsant activity of pyridoxal sulphate and phosphonoethyl pyridoxal: antagonism by GABA and its synthetic analogues. Neuropharmacology. 1983;22:865–873
  7. Ebadi M, Jobe PC, Laird HEI. The status of vitamin B6 metabolism in brains of genetically epilepsy-prone rats. Epilepsia. 1985;26:353–359
  8. Gottlieb A, Keydar I, Epstain HT. Rodent brain growth stages: An analytical review. Biol. Neonate. 1977;32:166–176
  9. Ishioka N, Sato J, Nakamura J, Ohkubo T, Takeda A, Kurioka S. In vivo modification of GABAA receptor with a high dose of pyridoxal phosphate induces tonic-clonic convulsion in immature mice. Neurochem. Int. 1995;26:369–373
  10. Kouyoumdjian JC, Ebadi M. Anticonvulsant activity of muscimol and gamma-aminobutyric acid against pyridoxal phosphate-induced epileptic seizures. J. Neurochem. 1981;36:251–257
  11. Mikolášová R, Velı́šek L, Vorlı́ček J, Mareš P. Developmental changes of ketamine action against epileptic afterdischarges induced by hippocampal stimulation in rats. Brain Res. 1994;81:105–112
  12. Morra M, Philipszoon HD, Andrea DG, Cananzi AR, Erario LR, Milone FF. Sensory and motor neuropathy caused by excessive ingestion of vitamin B6: a case report. Funct. Neurol. 1993;8:429–432
  13. Moshé, S.L., Velı́šek, L., Holmes, G.L., 1994. Developmental aspects of experimental seizures. In: Genton, P., Hirsch, E., Malafosse, A., Marescaux, C. (Eds.), International Workshop on Idiopathic Generalized Epilepsies: Clinical, Experimental and Genetic Aspects. John Libbey, London, pp. 51–64.
  14. Ohtsuka Y, Matsuda M, Ogino T, Kobayashi K, Ohtahara S. Treatment of the West syndrome with high-dose pyridoxal phosphate. Brain Dev. 1987;9:418–421
  15. Pietz J, Benninger C, Schafer H, Sontheimer D, Mittermaier G, Rating D. Treatment of infantile spasms with high-dosage vitamin B6. Epilepsia. 1993;34:757–763
  16. Schaeffer MC. Excess dietary vitamin B-6 alters startle behavior of rats. J. Nutr. 1993;123:1444–1452
  17. Schaumburg H, Kaplan J, Windebank A, Vick N, Rasmus S, Pleasure D. Sensory neuropathy from pyridoxine abuse. A new megavitamin syndrome. New Engl. J. Med. 1983;309:445–448
  18. Snodgrass SR. Vitamin neurotoxicity. Mol. Neurobiol. 1992;6:41–73
  19. Tyl RW, Price CJ, Marr MC, Kimmel CA. Developmental toxicity evaluation of Bendectin in CD rats. Teratology. 1988;37:539–552
  20. Waymire KG, Mahuren JD, Jaje JM, Guilarte TR, Coburn SP, MacGregor GR. Mice lacking tissue non-specific alkaline phosphatase die from seizures due to defective metabolism of vitamin B-6. Nat. Genet. 1995;11:45–51
  21. Weigand C, Eckler C, Chen K. Action and toxicity of vitamin B6 hydrochloride. Proc. Soc. Exp. Biol. Med. 1940;44:147–151
  22. Windebank AJ, Low PA, Blexrud MD, Schmelzer JD, Schaumburg HH. Pyridoxine neuropathy in rats: specific degeneration of sensory axons. Neurology. 1985;35:1617–1622

PII: S0920-1211(97)00088-0

Epilepsy Research
Volume 29, Issue 3 , Pages 259-264 , February 1998

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