Epilepsy Research
Volume 29, Issue 3 , Pages 259-264, February 1998

Proconvulsant effects induced by pyridoxine in young rats

  • Soňa Verešová

      Affiliations

    • Department of Pathological Physiology, Third Faculty of Medicine, Charles University, Ke Karlovu 4, 120 00, Prague, Czech Republic
    • ,
  • Radka Kábová

      Affiliations

    • Department of Pathological Physiology, Third Faculty of Medicine, Charles University, Ke Karlovu 4, 120 00, Prague, Czech Republic
    • ,
  • Libor Velı́šek

      Affiliations

    • Department of Pathological Physiology, Third Faculty of Medicine, Charles University, Ke Karlovu 4, 120 00, Prague, Czech Republic
    • Department of Neurology, Albert Einstein College of Medicine, K 312, 1410 Pelham Parkway South, Bronx, NY 10461, USA
    • Corresponding Author InformationCorresponding author. Tel: +1 718 4302469; fax: +1 718 4308899; e-mail: velisek@aecom.yu.edu; http://rfyzio.lf3.cuni.cz

Received 30 June 1997; received in revised form 9 September 1997; accepted 23 September 1997.

Abstract 

High doses of pyridoxine (vitamin B6) can be neurotoxic in adults. Effects of intraperitoneally administered B6 (100, 250 and 400 mg/kg) were studied in 7, 12, 18 and 60 day old rats. B6 elicited epileptiform EEG discharges without any motor correlate in all age groups. In contrast, motor seizures were rare, seen only in 18 day old rats (250 mg/kg of B6). Data indicate that in young rats, B6 may have proconvulsant effects in doses relevant to those sometimes used in pediatric neurology.

Keywords:  Vitamin B6, Toxicity, Seizures, Development

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PII: S0920-1211(97)00088-0

Epilepsy Research
Volume 29, Issue 3 , Pages 259-264, February 1998

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