Epilepsy Research
Volume 29, Issue 2 , Pages 161-166 , January 1998

High dose gabapentin in refractory partial epilepsy: clinical observations in 50 patients

Received 9 June 1997 ,Revised 10 September 1997 ,Accepted 14 September 1997.

References 

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  2. Crawford PM. The clinical efficacy of gabapentin. Revs Contemp Pharmacother. 1996;7:215–225
  3. Dichter MA, Brodie MJ. New antiepileptic drugs. New Engl J Med. 1996;334:1583–1590
  4. Forrest G, Sills GJ, Leach JP, Brodie MJ. Determination of gabapentin in plasma by high performance liquid chromatography. J Chromatogr Sec B. 1996;681:421–425
  5. Gee NS, Brown JP, Dissanayake VUK, Thurlow R, Offord J, Woodruff GN. The novel anticonvulsant drug, gabapentin (Neurontin), binds to the α2δ subunit of a calcium channel. J Biol Chem. 1996;271:5768–5776
  6. Leach JP, Girvan J, Paul A, Brodie MJ. Gabapentin and cognition: a double-blind, dose-ranging, placebo-controlled study in refractory epilepsy. J Neurol Neurosurg Psychiatry. 1997;62:372–376
  7. Lee DO, Steingard RL, Cesena M, Helmers SL, Rivello JJ, McKay MA. Behavioural side-effects of gabapentin in children. Epilepsia. 1996;37:87–90
  8. McKee PJW, Larkin JG, Brodie AF, Percy-Robb I, Brodie MJ. Five years of anticonvulsant monitoring on site at the epilepsy clinic. Ther Drug Monit. 1993;15:83–90
  9. McLean MJ. Gabapentin. Epilepsia. 1995;36(Suppl 2):S73–86
  10. UK Gabapentin Study Group. Gabapentin in partial epilepsy. Lancet 1990;335:1114–17.
  11. US Gabapentin Study Group. The long-term safety and efficacy of gabapentin (Neurontin) as add-on therapy in drug-resistant partial epilepsy. Epilepsy Res 1994;18:67–73.
  12. US Gabapentin Study Group No 5. Gabapentin as add-on therapy in refractory partial epilepsy. Neurology 1993;43:2292–98.
  13. Walker MK, Patsalos PN. The tolerability and safety profile of gabapentin. Revs Contemp Pharmacother. 1996;7:249–259
  14. Wamil AW, McLean MJ. Limitation by gabapentin of high frequency action potential firing by mouse cerebral neurones in cell culture. Epilepsy Res. 1994;17:1–11
  15. Wilson EA, Brodie MJ. New antiepileptic drugs. Modern management of epilepsy. In: Brodie MJ, Treiman DM, editors. Baillière's Clinical Neurology. London: Baillière-Tindall, 1996:723–47.
  16. Wolf SM, Shinnar S, Kang H, Gil KB, Moshé SL. Gabapentin toxicity in children manifesting as behavioural changes. Epilepsia. 1996;36:1203–1208

PII: S0920-1211(97)00078-8

Epilepsy Research
Volume 29, Issue 2 , Pages 161-166 , January 1998

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