Epilepsy Research
Volume 29, Issue 2 , Pages 135-146 , January 1998

Neurite extension of developing noradrenergic neurons is impaired in genetically epilepsy-prone rats (GEPR-3s): an in vitro study on the locus coeruleus

  • Rich W Clough

      Affiliations

    • Department of Anatomy, Southern Illinois University School of Medicine-Carbondale, Carbondale, IL 62901-6523, USA
    • Corresponding Author InformationCorresponding author. Tel.: +1 618 4531565; fax: +1 618 4531527; e-mail: rclough@som.siu.edu
    • ,
  • Brian R Peterson

      Affiliations

    • Department of Anatomy, Southern Illinois University School of Medicine-Carbondale, Carbondale, IL 62901-6523, USA
    • ,
  • Jennifer L Steenbergen

      Affiliations

    • Department of Biomedical and Therapeutic Sciences, University of Illinois College of Medicine-Peoria, Peoria, IL 61656, USA
    • ,
  • Phillip C Jobe

      Affiliations

    • Department of Biomedical and Therapeutic Sciences, University of Illinois College of Medicine-Peoria, Peoria, IL 61656, USA
    • ,
  • Jeffrey B Eells

      Affiliations

    • Department of Physiology, Southern Illinois University School of Medicine-Carbondale, Carbondale, IL 62901-6523, USA
    • ,
  • Ronald A Browning

      Affiliations

    • Department of Physiology, Southern Illinois University School of Medicine-Carbondale, Carbondale, IL 62901-6523, USA
    • ,
  • Pravin K Mishra

      Affiliations

    • Department of Biomedical and Therapeutic Sciences, University of Illinois College of Medicine-Peoria, Peoria, IL 61656, USA

Received 28 March 1997 ,Revised 18 July 1997 ,Accepted 3 September 1997.

References 

  1. Altman J, Bayer SA. Atlas of Prenatal Rat Brain Development. Boca Raton, FL: CRC Press, 1995.
  2. Browning RA. Neuroanatomical localization of structures responsible for seizures in the GEPR: Lesion studies. Life Sci. 1986;39:857–867
  3. Browning RA, Wade DR, Marcinczyk M, Long GL, Jobe PC. Regional brain abnormalities in norepinephrine uptake and dopamine beta-hydroxylase activity in the genetically epilepsy-prone rat. J Pharmacol Exp Ther. 1989;249:229–235
  4. Clough RW, Browning RA, Maring ML, Jobe PC. Intracerebral grafting of fetal dorsal pons in genetically epilepsy-prone rats: Effects on audiogenic seizures. Exp Neurol. 1991;112:195–199
  5. Clough RW, Browning RA, Maring ML, Statnick MA, Wang C, Jobe PC. Effects of intraventricular locus coeruleus transplants on seizure severity in genetically epilepsy-prone rats following depletion of brain norepinephrine. J Neural Transplant Plast. 1994;5:65–79
  6. Clough RW, Eells JB, Browning RA, Jobe PC. Seizures and Proto-oncogene expression of fos in the brain of adult genetically epilepsy-prone rats (GEPRs). Exp Neurol 1997;146:341–53.
  7. DiPorzio U, Estenoz M. Positive control of target cerebellar cells on norepinephrine uptake in embryonic brainstem cultures in serum-free medium. Dev Brain Res. 1984;16:147–157
  8. Dreyfus CF, Markey KA, Goldstein M, Black IB. Development of catecholamine phenotypic characters in the mouse locus coeruleus in vivo and in culture. Dev Biol. 1983;97:48–58
  9. Eells JB, Clough RW, Browning RA, Jobe PC. Fos immunoreactivity in locus coeruleus neurons following audiogenic seizure in the genetically epilepsy-prone rat: comparison to electroshock and pentylenetetrazol seizure models. Neurosci Lett. 1997;233(1):21–24
  10. Faingold CL, Gehlbach G, Caspary DM. Decreased effectiveness of GABA-mediumted inhibition in the inferior colliculus of the genetically epilepsy-prone rat. Exp Neurol. 1986;93:145–159
  11. Faingold CA. The genetically epilepsy prone rat. Gen Pharmacol. 1988;19:331–338
  12. Jobe PC, Mishra PK, Browning RA, Wang C, Adams-Curtis LE, Ko KH, et al. Norepinephrine abnormalities in the genetically epilepsy-prone rat. Brain Res Bull. 1994;5:493–504
  13. Jobe PC, Laird II HE. Neurotransmitter systems and the epilepsy models: distinguishing features and unifying principles. In: Jobe PC, Laird II HE, editors. Neurotransmitters and Epilepsy. Clifton, NJ: Humana Press, 1987.
  14. Jobe PC, Mishra PK, Ludvig N, Dailey JW. Genetic models of the epilepsies. In: Schwartzkroin PA. (Ed.), Concepts and Models in Epilepsy Research. Cambridge: Cambridge University Press, 1993.
  15. Ko KH, Dailey JW, Jobe PC. Effect of increments in norepinephrine concentrations on seizure intensity in the genetically epilepsy-prone rat. J Pharmacol Exp Ther. 1982;222:662–669
  16. Kobayashi RM, Palkovits M, Kopin IJ, Jacobowitz DM. Biochemical mapping of noradrenergic nerves arising from the rat locus coeruleus. Brain Res. 1974;77:269–279
  17. Lauterborn JC, Ribak CE. Differences in dopamine-beta-hydroxylase immunoreactivity between the brains of genetically epilepsy-prone and Sprague-Dawley rats. Epilepsy Res. 1989;4:161–176
  18. Paxinos G, Tork I, Tecott LH, Valentino KL. Atlas of the developing rat brain. San Diego, CA: Academic Press, 1991.
  19. Reigel CE, Dailey JW, Jobe PC. The genetically epilepsy-prone rat: An overview of seizure-prone characteristics and responsiveness to anticonvulsant drugs. Life Sci. 1986;39:763–774
  20. Reigel CE, Joliff JL, Jobe PC, Mishra PK. Ontogeny of subcortical monoaminergic determinants of epilepsy in the genetically epilepsy-prone rat. FASEB J. 1988;2:4492
  21. Reigel CE, Mishra PK, Jobe PC, Joliff JL. Ontogeny of noradrenergic determinants of seizure susceptibility and severity in the genetically epilepsy-prone rat. Fed Proc. 1987;46:706
  22. Robinson LJ, Black IB, Dreyfus CF. Hippocampal regulation of the survival and morphological development of locus coeruleus neurons in dissociated cell culture. J Comp Neurol. 1993;333:567–577
  23. Sklair L, Segal M. Target cell stimulation and inhibition of norepinephrine uptake in dissociated rat locus coeruleus cultures. Dev Brain Res. 1990;52:191–199
  24. Sklair-Tavron L, Nestler EJ. Opposing effects of morphine and the neurotrophins, NTS, NT4 and BDNF on locus coeruleus neurons in vitro. Brain Res. 1995;702:117–125
  25. Statnick MA, Dailey JW, Jobe PC, Browning RA. Abnormalities in brain serotonin concentration, high-affinity uptake, and tryptophan hydroxylase activity in severe-seizure genetically epilepsy-prone rats. Epilepsia. 1996;37:311–321
  26. Statnick MA, Maring-Smith ML, Clough RW, Wang C, Dailey JW, Jobe PC, et al. Effect of 5,7-dihydroxytryptamine on audiogenic seizures in genetically epilepsy-prone rats. Life Sci. 1996;59:1763–1771
  27. Williams JT, North RA, Shefner SA, Nishi S, Egan TM. Membrane properties of rat locus coeruleus neurons. Neuroscience. 1984;13:137–156

PII: S0920-1211(97)00076-4

Epilepsy Research
Volume 29, Issue 2 , Pages 135-146 , January 1998

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