Epilepsy Research
Volume 29, Issue 2 , Pages 129-134 , January 1998

Diazepam binding inhibitor (DBI) in the plasma of pediatric and adult epileptic patients

  • Carlo Ferrarese

      Affiliations

    • Scientific Institute `E. Medea', Bosisio Parini, Lecco, Italy
    • Department of Neurology, University of Milan, Monza, Italy
    • Corresponding Author InformationCorresponding author. Department of Neurology and Epilepsy Center, University of Milan, Ospedale San Gerardo, Via Donizetti 106, 20052 Monza, Italy. Tel.: +39 39 2333598; fax: +39 39 2300155; e-mail: carlofer@imiucca.csi.unimi.it
    • ,
  • Tiziana Cogliati

      Affiliations

    • Scientific Institute `E. Medea', Bosisio Parini, Lecco, Italy
    • Department of Neurology, University of Milan, Monza, Italy
    • ,
  • Rachele Tortorella

      Affiliations

    • Scientific Institute `E. Medea', Bosisio Parini, Lecco, Italy
    • Department of Neurology, University of Milan, Monza, Italy
    • ,
  • Claudio Zucca

      Affiliations

    • Scientific Institute `E. Medea', Bosisio Parini, Lecco, Italy
    • ,
  • Graziella Bogliun

      Affiliations

    • Department of Neurology, University of Milan, Monza, Italy
    • ,
  • Ettore Beghi

      Affiliations

    • Department of Neurology, University of Milan, Monza, Italy
    • ,
  • Davide Passoni

      Affiliations

    • Scientific Institute `E. Medea', Bosisio Parini, Lecco, Italy
    • Department of Neurology, University of Milan, Monza, Italy
    • ,
  • Chiara Zoia

      Affiliations

    • Department of Neurology, University of Milan, Monza, Italy
    • Department of Anatomy, University of Milan, Monza, Italy
    • ,
  • Barbara Begni

      Affiliations

    • Department of Neurology, University of Milan, Monza, Italy
    • ,
  • Larissa Airoldi

      Affiliations

    • Department of Neurology, University of Milan, Monza, Italy
    • ,
  • Hannu Alho

      Affiliations

    • Department of Alcohol Research, National Public Health Institute, Helsinki, Finland
    • ,
  • Lodovico Frattola

      Affiliations

    • Department of Neurology, University of Milan, Monza, Italy

Received 4 April 1997 ,Revised 14 August 1997 ,Accepted 24 August 1997.

References 

  1. Anholt PRH, Pedersen PL, De Souza EB, Snyder SH. The peripheral-type benzodiazepine receptor. Localization to the mitochondrial outer membrane. J Biol Chem. 1986;261:576–583
  2. Berkovich A, Ferrarese C, Cavaletti G, Alho H, Marzorati C, Bianchi G, et al. Topology of two DBI receptors in human lymphocytes. Life Sci. 1993;52:1265–1277
  3. Commission on Classification and Terminology of the International League Against Epilepsy . Proposal for revised classification of epilepsies and epileptic syndromes. Epilepsia. 1989;30(4):389–399
  4. Costa E, Guidotti A, Toffano G. Molecular mechanisms mediating the action of diazepam on GABA receptors. Br J Psychiatry. 1978;133:239–248
  5. Costa E, Guidotti A. Commentary: Endogenous ligands for benzodiazepine recognition sites. Biochem Pharmacol. 1985;34:3399–3403
  6. Ferrarese C, Appollonio I, Frigo M, Perego M, Pierpaoli C, Trabucchi M, et al. Characterization of peripheral benzodiazepine receptors in human blood mononuclear cells. Neuropharmacology. 1990;29:375–378
  7. Ferrarese C, Appollonio I, Bianchi G, Frigo M, Marzorati C, Pecora N, et al. Benzodiazepine receptors and diazepam binding inhibitor: a possible link between stress, anxiety and the immune system. Psychoneuroendocrinology. 1993;18:3–22
  8. Ferrarese C, Marzorati C, Perego M, Bianchi G, Cavarretta R, Pierpaoli C, et al. Effect of anticonvulsant drugs on peripheral benzodiazepine receptors of human lymphocytes. Neuropharmacology. 1995;34:427–431
  9. Ferrarese C, Perego M, Marzorati C, Bianchi G, Frigo M, Pecora N, et al. Modifications of diazepam binding inhibitor and peripheral benzodiazepine receptors in lymphocytes of epileptic patients. Italian J Neurol Sci. 1996;17:141–145
  10. Ferrarese C, Tortorella R, Bogliun G, Beghi E, Cogliati T, Zoia C, Passoni D, Frattola L. Decreased density of lymphocyte benzodiazepine receptors in drug-resistant epileptic patients. Epilepsy Res 1997;27:181–185.
  11. Guidotti A, Berkovich A, Ferrarese C, Santi MR, Costa E. Neuronal-glial differential processing of DBI to yield ligands to central or peripheral benzodiazepine recognition sites. In: Sauvanet P, Langer SZ, Morselli PL, editors. Imidazopyridines in Sleep Disorders. New York: Raven Press, 1988:25–38.
  12. Johnson EW, de Lanerolle NC, Kim JH, Sundersan S, Spencer DD, Mattson RH, et al. Central and peripheral benzodiazepine receptors: opposite changes in human epileptogenic tissue. Neurology. 1992;42:811–815
  13. Papadopoulos V, Guarneri P, Krueger KE, Guidotti A, Costa E. Pregnenolone biosynthesis in C6-2B glioma cell mitochondria: regulation by a mitochondrial diazepam binding inhibitor receptor. Proc Natl Acad Sci USA. 1992;89:5113–5117
  14. Puia G, Santi MR, Vicini S, Pritchett DB, Purdy RH, Paul SM, et al. Neurosteroids act on recombinant human GABA-A receptors. Neuron. 1990;4:759–765
  15. Taupin V, Herbelin A, Descamps-Latscha B, Zavala F. Endogenous anxiogenic peptide, ODN-diazepam-binding inhibitor, and benzodiazepines enhance the production of interleukin-1 and tumor necrosis factor by human monocytes. Lymphokine Cytokine Res. 1991;10:7–13
  16. Vezzani A, Serafini R, Stasi M, Samanin R, Ferrarese C. Epileptogenic activity of two peptides derived from diazepam binding inhibitor after intrahippocampal injection in rats. Epilepsia. 1991;32:597–603

PII: S0920-1211(97)00074-0

Epilepsy Research
Volume 29, Issue 2 , Pages 129-134 , January 1998

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