Comparison of EEG, MRI and PET in reading epilepsy: a case report

J. Koepp, Matthias; Hansen, Marie-Luise; Pressler, Ronit M; Brooks, David J; Brandl, Ulrich; Guldin, Barbara; Duncan, John S; Ried, Sibylle

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Volume 29, Issue 3 , Pages 251-257, February 1998

Comparison of EEG, MRI and PET in reading epilepsy: a case report

Matthias J. Koepp
- Department of Neurology, Universitatsklinikum Rudolf Virchow, Berlin, Germany
- MRC Cyclotron Unit, Hammersmith Hospital, DuCane Road, London, UK
- Corresponding author.
Marie-Luise Hansen
- Department of Neurology, Universitatsklinikum Rudolf Virchow, Berlin, Germany
Ronit M Pressler
- Department of Pediatrics, Universitatsklinikom Rudolf Virchow, Berlin, Germany
David J Brooks
- MRC Cyclotron Unit, Hammersmith Hospital, DuCane Road, London, UK
Ulrich Brandl
- Department of Pediatrics, Universitatsklinikom Rudolf Virchow, Berlin, Germany
Barbara Guldin
- Department of Neurology, Universitatsklinikum Rudolf Virchow, Berlin, Germany
John S Duncan
- MRC Cyclotron Unit, Hammersmith Hospital, DuCane Road, London, UK
Sibylle Ried
- Department of Neurology, Universitatsklinikum Rudolf Virchow, Berlin, Germany

Received 11 November 1996; received in revised form 20 June 1997; accepted 29 June 1997.

Abstract

The pathophysiological and neuroanatomical bases of reading epilepsy (RE) are unclear. We performed video-EEG, high quality MRI and [¹¹C]diprenorphine PET in a patient with RE to detect structural and functional abnormalities. EEG showed multifocal seizure onset bilaterally in temporal and fronto-central regions. MRI was normal, whereas [¹¹C]diprenorphine PET revealed peri-ictal opioid binding decreases in both temporal lobes and the left frontal lobe. These findings confirm that RE is due to abnormal activity in the network subserving reading.

Keywords: Reading epilepsy, EEG mapping, [¹¹C]diprenorphine PET