Epilepsy Research
Volume 27, Issue 3 , Pages 205-213 , June 1997

A double-blind controlled clinical trial of oxcarbazepine versus phenytoin in children and adolescents with epilepsy1

  • Marilisa M Guerreiro

      Affiliations

    • Neurological Department, Faculty of Medicine, UNICAMP, Campinas, Brazil
    • ,
  • Ulf Vigonius

      Affiliations

    • Novartis Sverige AB, Västra Frölunda, Sweden
    • Corresponding Author InformationCorresponding author. Present address: Novartis Sverige AB, P.O. Box 1150, S-183 11 Taeby, Sweden.
    • ,
  • Harald Pohlmann

      Affiliations

    • Novartis Pharma AG, Basel, Switzerland
    • ,
  • Maria Luiza G de Manreza

      Affiliations

    • Neurological Department, Hospital Das Clinicas, Sao Paulo, Brazil
    • ,
  • Natalio Fejerman

      Affiliations

    • Neurological Department, Children Hospital `Professor Dr Juan P. Garrahan', Buenos Aires, Argentina
    • ,
  • Sergio A Antoniuk

      Affiliations

    • Neurological Department, Hospital Nossa Senhora das Gracas, Curitiba, Brazil
    • ,
  • Alan Moore

      Affiliations

    • Novartis Pharma AG, Basel, Switzerland

Received 26 March 1997 ,Revised 11 April 1997 ,Accepted 13 April 1997.

References 

  1. Faigle JW, Menge GP. Metabolic characteristics of oxcarbazepine (Trileptal) and their beneficial implications for enzyme induction and drug interactions. Behav Neurol. 1990;3(1):21–30
  2. Grant SM, Faulds D. Oxcarbazepine. A review of its pharmacology and therapeutic potential in epilepsy, trigeminal neuralgia and affective disorders. Drugs. 1992;43:873–888
  3. Schmutz M, Brugger F, Gentsch C, McLean MJ, Olpe HR. Oxcarbazepine: preclinical anticonvulsant profile and putative mechanism of action. Epilepsia. 1994;35(5):S47–S50
  4. Dam M, Ekberg R, Loyning Y, Waltimo O, Jakobsen K. A double-blind study comparing oxcarbazepine and carbamazepine in patients with newly diagnosed, previously untreated epilepsy. Epilepsy Res. 1989;3(1):70–76
  5. Reinikainen KJ, Kraenen T, Halonen T, Komulainen H, Riekkinen PJ. Comparison of oxcarbazepine and carbamazepine: a double-blind study. Epilepsy Res. 1987;1(5):284–289
  6. Friis ML, Kristensen O, Boas J, Dalby M, Deth SH, Gram L. Therapeutic experiences with 947 epileptic out-patients in oxcarbazepine treatment. Acta Neurol Scand. 1993;87(3):224–227
  7. For the OT/F10 Study Group Vigonius U, Moore A, Kraemer G, Canger R, Deisenhammer E, Schiwy W. Oxcarbazepine: Results of a clinical trial designed to assess the feasibility of a twice-daily administration. Epilepsia Abs. 1995;36(3):S119
  8. Dam M. Drug therapy for different types of seizures. In: Sillanpää M, Johannessen SI, Blennow G, Dam M, editors. Paediatric Epilepsy. Wrightson Biomedical Publishing, 1990, pp. 269–278.
  9. Rylance GW. Treatment of epilepsy and febrile convulsions in children. Lancet. 1990;336:488–491
  10. The Commission on Classification and Terminology of the International League Against Epilepsy. Proposal for revised clinical and electroencephalographic classification of epileptic seizures. Epilepsia 1981;22(4):489–501.
  11. The Commission on Classification and Terminology of the International League Against Epilepsy. Proposal for revised classification of epilepsies and epileptic syndromes. Epilepsia 1989;30(4):389–399.
  12. Sidenwall R. Epidemiology. In: Sillanpää M, Johannessen SI, Blennow G, Dam G, editors. Paediatric Epilepsy, Wrightson Biomedical Publishing, 1990:1–8.
  13. Heijbel J. Benign partial epilepsy in childhood. In: Sillanpää M, Johannessen SI, Blennow G, Dam M, editors. Paediatric Epilepsy, Wrightson Biomedical Publishing, 1990:111–122.
  14. Sander JWAS. Some aspects of prognosis in epilepsies: A review. Epilepsia. 1993;34(6):1007–1016
  15. Trileptal Summary of Product Characteristics, Ciba-Geigy Limited, Basel, March 24, 1993.
  16. Van Amelsvoort T, Bakshi R, Devaux CB, Schwabe S. Hyponatremia associated with carbamazepine and oxcarbazepine therapy: A Review. Epilepsia. 1994;35(1):181–188
  17. Klosterskov Jensen P. Oxcarbazepine (Trileptal) in anti-epileptic polytherapy. Behav. Neurol. 1990;3(1):S35–S39
  18. Motte J, Arzimanoglou AA, Billard C, et al.  Open study of tolerability of oxcarbazepine in children. Epilepsia Abs. 1995;36(3):S118
  19. Gaily E, Granström M-L, Lindahl E. Oxcarbazepine in early childhood epilepsy. Epilepsia Abs. 1995;36(3):S118

PII: S0920-1211(97)00025-9

Epilepsy Research
Volume 27, Issue 3 , Pages 205-213 , June 1997

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