Epilepsy Research
Volume 28, Issue 1 , Pages 17-28 , July 1997

AWD 140–190: a new anticonvulsant with a very good margin of safety

  • Angelika Rostock

      Affiliations

    • Department of Pharmacology, Corporate Research and Development, ASTA Medica Group, Arzneimittelwerk Dresden GmbH, Meißner Str. 191, D-01445 Radebeul, Germany
    • Corresponding Author InformationCorresponding author.
    • ,
  • Christine Tober

      Affiliations

    • Department of Pharmacology, Corporate Research and Development, ASTA Medica Group, Arzneimittelwerk Dresden GmbH, Meißner Str. 191, D-01445 Radebeul, Germany
    • ,
  • Chris Rundfeldt

      Affiliations

    • Department of Pharmacology, Corporate Research and Development, ASTA Medica Group, Arzneimittelwerk Dresden GmbH, Meißner Str. 191, D-01445 Radebeul, Germany
    • ,
  • Reni Bartsch

      Affiliations

    • Department of Pharmacology, Corporate Research and Development, ASTA Medica Group, Arzneimittelwerk Dresden GmbH, Meißner Str. 191, D-01445 Radebeul, Germany
    • ,
  • Klaus Unverferth

      Affiliations

    • Department of Pharmacology, Corporate Research and Development, ASTA Medica Group, Arzneimittelwerk Dresden GmbH, Meißner Str. 191, D-01445 Radebeul, Germany
    • ,
  • Jürgen Engel

      Affiliations

    • Department of Pharmacology, Corporate Research and Development, ASTA Medica Group, Arzneimittelwerk Dresden GmbH, Meißner Str. 191, D-01445 Radebeul, Germany
    • ,
  • Harold H Wolf

      Affiliations

    • Anticonvulsant Screening Project, Department of Pharmacology and Toxicology, University of Utah, Salt Lake City, UT, USA
    • ,
  • H.Steve White

      Affiliations

    • Anticonvulsant Screening Project, Department of Pharmacology and Toxicology, University of Utah, Salt Lake City, UT, USA

Received 17 October 1996 ,Revised 18 February 1997 ,Accepted 6 April 1997.

References 

  1. Dam M. Intractable epilepsy: Introduction. In: Schmidt D, Morselli PL, editors. Intractable Epilepsy: Experimental and Clinical Aspects. New York, NY: Raven Press, 1986:1–3.
  2. Kimball AW, Burnett WT, Doherty DG. Chemical protection against ionizing radiation. I. Sampling methods for screening compounds in radiation protection studies with mice. Radiat Res. 1957;7:1–12
  3. Litchfield JT, Wilcoxon F. A simplified method of evaluating dose–effect experiments. J Pharmacol Exp Ther. 1949;96:99–113
  4. Loiseau P. Do we need novel anti-epileptic drugs?. Br J Clin Pract. 1988;42:2–3
  5. Rostock A, Rundfeldt C, Tober C, Bartsch R. AWD 140–190: A new anticonvulsant with sodium channel blocking properties. Soc Neurosci Abstr. 1995;21:203
  6. Rostock A, Tober C, Seidel B, Bartsch R. Anticonvulsant activity and plasma concentration of AWD 140–190 in rats. Epilepsia. 1995;36(Suppl 4):50
  7. Rundfeldt C, Wlaz P, Hönack D, Löscher W. Anticonvulsant tolerance and withdrawal characteristics of benzodiazepine receptor ligands in different seizure models in mice. Comparison of diazepam, bretazenil and abecarnil. J Pharmacol Exp Ther. 1996;275:693–702
  8. Sander JW, Shorvon SD. Incidence and prevalence studies in epilepsy and their methodological problems: a review. J Neurol Neurosurg Psychiatry. 1987;50:829–839
  9. Schmidt D. Anticonvulsants. In: Dukes MNG, editor. Meyler's Side Effects of Drugs, 12th Edition. Amsterdam: Elsevier Science, 1992:122–143.
  10. Schmidt D, Morselli PL, editors. Intractable Epilepsy: Experimental and Clinical Aspects. New York: Raven Press, 1986.
  11. Swinyard EA. Laboratory evaluation of antiepileptic drugs. Review of laboratory methods. Epilepsia. 1969;10:107–119
  12. Swinyard EA, Wolf HH, White S, Skeen GA, Stark LG, Albertson T, et al. Characterisation of the anticonvulsant properties of F-721. Epilepsy Res. 1993;15:35–45
  13. Tober C, Jainta H, Rundfeldt C, Rostock A, Bartsch R. Anticonvulsant and antiepileptogenic effects of D-23129 in the kindling model of focal epilepsy. Naunyn-Schmiedeberg's Arch Pharmacol. 1995;351(Suppl):R160
  14. Tober C, Rostock A, Rundfeldt C, Bartsch R. D-23129: a potent anticonvulsant in the amygdala kindling model of complex partial seizures. Eur J Pharmacol. 1996;303:163–169
  15. Unverferth K, Lankau H-J, Günther R, Rostock A, Rundfeldt C. Synthesis and anticonvulsant activity of 3-aminipyrroles. In: IBC's International Conference on Epilepsia, 5–6 Febr. 1996, Orlando, FL.
  16. White HS, Wolf HH, Swinyard A, Skeen GA, Sofia RD. A neuropharmacological evaluation of felbamate as a novel anticonvulsant. Epilepsia. 1992;33:564–572

PII: S0920-1211(97)00023-5

Epilepsy Research
Volume 28, Issue 1 , Pages 17-28 , July 1997

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