Epilepsy Research
Volume 26, Issue 2 , Pages 389-395 , January 1997

Randomized trial comparing vigabatrin and hydrocortisone in infantile spasms due to tuberous sclerosis1

  • C Chiron

      Affiliations

    • Department of Child Neurology and INSERM U29, Hôpital Saint Vincent de Paul, and Université René Descartes, 82 avenue Denfert-Rochereau, 75 674 Paris Cedex 14, France
    • Corresponding Author InformationCorresponding author. Tel.: +3301 40488045; fax: +3301 40488046.
    • ,
  • C Dumas

      Affiliations

    • Marion Merrell SA, Levallois-Perret, France
    • ,
  • I Jambaqué

      Affiliations

    • Department of Child Neurology and INSERM U29, Hôpital Saint Vincent de Paul, and Université René Descartes, 82 avenue Denfert-Rochereau, 75 674 Paris Cedex 14, France
    • ,
  • J Mumford

      Affiliations

    • Marion Merrell UK Ltd, Research Centre, Winnersh, Berkshire, UK
    • ,
  • O Dulac

      Affiliations

    • Department of Child Neurology and INSERM U29, Hôpital Saint Vincent de Paul, and Université René Descartes, 82 avenue Denfert-Rochereau, 75 674 Paris Cedex 14, France

Received 12 June 1996 ,Revised 1 October 1996 ,Accepted 8 October 1996.

References 

  1. Aicardi, J., Weinman, S., Chevrie, J.J. and Thieffry, S., Les spasmes en flexion du nourrisson. Etude de l'excretion urinaire du 17-hydroxy-cortico-steroide et du taux de secretion du cortisol au cours de leur traitement par l'ACTH, Arch. Fr. Pediatr., 24 (1967) 521–530.
  2. Aicardi, J. and the Coordinating Peer Review Group, the European IS Vigabatrin Group, European experience with use of vigabatrin as first-line monotherapy in Infantile Spasms, Epilepsia, 36 (1995) S102.
  3. Appleton, R.E. and Monteil-Viecca, F., Vigabatrin in infantile spasms. Why add-on? Lancet, 341 (1992) 962.
  4. Buti, D., Lini, M., Bardini, R., Marvulli, I., Tromboni, P. and Nencioli, L., Early treatment of infantile spasms with vigabatrin monotherapy: Results in 4 patients, Epilepsia, 32 (1991) S89.
  5. Chiron, C., Dulac, O., Beaumont, D., Palacios, L., Pajot, N. and Mumford, J., Therapeutic trial of vigabatrin in refractory infantile spasms, J. Child Neurol., 6 (1991) S52–S59.
  6. Dreifuss, F., Farwell, J., Holmes, G. and Joseph, C., Infantile spasms, comparative trial of nitrazepam and corticotropin, Arch. Neurol., 43 (1986) 1107–1110.
  7. Dulac, O. and Plouin, P., Infantile spasms and West syndrome. In: E. Wyllie (Ed.), The Treatment of Epilepsy: Principles and Practice, Lea and Febiger, Philadelphia, 1993, pp. 464–491.
  8. Dulac, O. and Schlumberger, E., Treatment of West syndrome. In: E. Wyllie (Ed), The Treatment of Epilepsy: Principles and Practice, Lea and Febiger, Philadelphia, 1993, pp. 595–604.
  9. Dulac, O., Chiron, C., Robain, O., Plouin, P., Jambaque, I. and Pinard, J.M., Infantile spasms: a pathophysiological hypothesis, Semin. Paediatr. Neurol., 2 (1994) 83–89.
  10. Gomez, M.R. (Ed), Tuberous sclerosis, 2nd edn., Raven, New York, 1988.
  11. Hrachovy, R.A., Frost, J.D., Kellaway, P. and Zion, T.E., Double-blind study of ACTH vs prednisone therapy in infantile spasms, J. Paediatr., (1983) 641–645.
  12. Hrachovy, R.A,. Glaze, D.G. and Frost, J.D., A retrospective study of spontaneous remission and long-term outcome in patients with infantile spasms, Epilepsia, 32 (1991) 212–214.
  13. Hunt, A. and Dennis, J.J., Psychiatric disorders among children with tuberous sclerosis, Dev. Med. Child. Neurol., 29 (1987) 190–198.
  14. Jambaque, I., Cusmai, R., Curatolo, P., Cortesi, R., Perrot, C. and Dulac, O., Neuropsychological aspects of tuberous sclerosis: relation to epilepsy and MRI findings, Dev. Med. Child Neurol., 33 (1991) 698–705.
  15. Jeavons, P.M. and Bower, B.D., Infantile spasms. In: P.J. Vinken, G.W. Bruyn (Eds.), The Epilepsies, Handbook of Clinical Neurology, Elsevier, New York, 1974, pp. 219–234.
  16. Lortie, A., Chiron, C., Mumford, J. and Dulac, O., The potential for increasing seizure frequency, relapse, and appearance of new seizure types with Vigabatrin, Neurology, 43 (1993) S24–S27.
  17. Schlumberger, E. and Dulac, O., A simple, effective and well-tolerated regime for West syndrome, Dev. Med. Child Neurol., 36 (1994) 863–872.
  18. Vles, J.S., Van der Heyden, A.M., Ghijs, A. and Troost, J., Vigabatrin in the treatment of Infantile spasms, J. Neuropediatr., 24 (1993) 230–231.

PII: S0920-1211(96)01006-6

doi: 10.1016/S0920-1211(96)01006-6

Epilepsy Research
Volume 26, Issue 2 , Pages 389-395 , January 1997

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