Epilepsy Research
Volume 26, Issue 2 , Pages 345-349 , January 1997

Influence of ethosuximide on valproic acid serum concentrations

  • Ritva Anneli Sälke-Kellermann

      Affiliations

    • Epilepsy Centre Bethel, Kidron, D-33 617 Bielefeld, Germany
    • Corresponding Author InformationCorresponding author. Present address: Swiss Epilepsy Center, Bleulerstrasse 60, CH-8008 Zurich, Switzerland.
    • ,
  • Theo May

      Affiliations

    • Biochemical Laboratory, Society of Epilepsy Research Bethel, D-33 617 Bielefeld, Germany
    • ,
  • Hans Erich Boenigk

      Affiliations

    • Epilepsy Centre Bethel, Kidron, D-33 617 Bielefeld, Germany

Received 15 August 1996 ,Accepted 23 August 1996.

References 

  1. Battino, D., Cusi, C., Franceschetti, S., Moise, A., Spina, S. and Avanzini, G., Ethosuximide plasma concentrations: Influence of age and associated concomitant therapy, Clin. Pharmacokinet., 7 (1982) 176–180.
  2. Bauer, L.A., Harris, C., Wilensky, A.J., Raisys, V.A. and Levy, R.H., Ethosuximide kinetics: Possible interaction with valproic acid, Clin. Pharmacol. Ther., 31, 8 (1982) 741–745.
  3. Chang, T., Dill, W.A. and Glazko, A.J., Ethosuximide: Absorption, distribution and excretion. In: D.M. Woodbury, J.K. Penry, and R.P. Schmidt (Eds.), Antiepileptic Drugs, Raven Press, New York, 1972, pp. 417–423.
  4. Flachs, H., Würtz-Joergensen, A., Gram, L. and Wulf, K., Sodium di-n-propyl acetate - its interaction with other antiepileptic drugs, Pharm. Weekbl., 112 (1977) 320.
  5. Juergens, U., HPLC analysis of antiepileptic drugs in blood samples. Micropore separation of fourteen compounds, J. Liq. Chromatogr., 10 (2 and 3) (1987) 507–532.
  6. Martinovic, Z., Comparison of ethosuximide with sodium valproate as monotherapies of absence seizures. In: M. Parsonage (Ed.), Advances in Epileptology, XIVth Epilepsy International Symposium, Raven Press, New York, 1983, pp. 301–305.
  7. Mattson, R.H. and Cramer, J.A., Valproic acid and ethosuximide interaction, Ann. Neurol., 7 (1980) 583–584.
  8. Pisani, F., Narbone, M.C., Trunfio, C., Fazio, A., La Rosa, G., Oteri, G. and Di Perri, R., Valproic acid-ethosuximide interaction: A pharmacokinetic study, Epilepsia, 25 (2) (1984) 229–233.
  9. Sälke-Kellermann, R.A., Klinische Pharmakologie von Ethosuximid: Zwei prospektive Studien über die Fluktuationen der Serumkonzentrationen im Tagesverlauf, abhängig vom Dosierungsschema, und über die Eliminationshalbwertszeit unter klinischen Bedingungen, Thesis, Münster, 1993.

PII: S0920-1211(96)01001-7

doi: 10.1016/S0920-1211(96)01001-7

Epilepsy Research
Volume 26, Issue 2 , Pages 345-349 , January 1997

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