Epilepsy Research
Volume 26, Issue 2 , Pages 329-333 , January 1997

Generation of lipid radicals in the hippocampal extracellular space during kainic acid-induced seizures in rats

  • Y Ueda

      Affiliations

    • Institute for Life Support Technology, Yamagata Technopolis Foundation, Matsusakae 2-2-1, Yamagata 990, Japan
    • Department of Psychiatry, Miyazaki Medical College, Kihara 5200, Kiyotake-cho, Miyazaki-gun, Miyazaki 889-16, Japan
    • Corresponding Author InformationCorresponding author, Department of Psychiatry, Miyazaki Medical College, Kihara 5200, Kiyotake-cho, Miyazaki, 889-16, Japan. Tel.: 0985 852969; fax: 0985 855475; e-mail: usan@post.miyazaki-med.ac.jp.
    • ,
  • H Yokoyama

      Affiliations

    • Institute for Life Support Technology, Yamagata Technopolis Foundation, Matsusakae 2-2-1, Yamagata 990, Japan
    • ,
  • R Niwa

      Affiliations

    • Medical Chemistry Department, Central Research Institute, Nissin Food Products Co. Ltd., Daishougun 1-11-14, Ohtsu, Shiga 520-21, Japan
    • ,
  • R Konaka

      Affiliations

    • Department of Biochemistry, Osaka City University Medical School, Asahimachi 1-4-54, Abeno, Osaka 545, Japan
    • ,
  • H Ohya-Nishiguchi

      Affiliations

    • Institute for Life Support Technology, Yamagata Technopolis Foundation, Matsusakae 2-2-1, Yamagata 990, Japan
    • ,
  • H Kamada

      Affiliations

    • Institute for Life Support Technology, Yamagata Technopolis Foundation, Matsusakae 2-2-1, Yamagata 990, Japan

Received 14 May 1996 ,Revised 12 August 1996 ,Accepted 14 August 1996.

References 

  1. Annadora, J., Bruce, A.J. and Baudry, M., Oxygen free radicals in rat limbic structures after kainate-induced seizures, Free Rad. Biol. Med., 18 (1995) 993–1002.
  2. Bruce, A.J. and Baudry, M., Oxygen free radicals in rat limbic structures after kainate-induced seizures, Free Rad. Biol. Med., 18 (1995) 993–1002.
  3. Bruce, A., Najm, I., Malfroy, B. and Baudry, M., Effects of desferrioxamine/manganese complex, a superoxide dismutase-mimic, on kainate-induced pathology in rat brain, Neuroscience, 13 (1992) 265–271.
  4. Carney, J.M., Starke-Reed, P.E., Oliver, C.N., Landum, R.W., Cheng, M.S., Wu, J.F. and Floyd, R.A., Reversal of age-related increase in brain protein oxidation, decrease in enzyme activity, and loss in temporal and spatial memory by chronic administration of the spin-trapping compound N-tert-butyl-a-phenylnitrone, Proc. Natl. Acad. Sci. USA, 88 (1991) 3633–3636.
  5. Cohen, M.R., Ramchand, C.N., Sailer, V., Fernandez, M., McAmis, W., Sridhara, N. and Alson, C., Detoxification enzymes following intrastriatal kainic acid, Neurochem. Res., 12 (1987) 425–429.
  6. Connor, H.D., Fischer, V. and Mason, R.P., A search of oxygen centered free radicals in the lipoxygenase/linoleic acid system, Biochem. Biophys. Res. Commun., 141 (1986) 614–621.
  7. Coyle, J.T. and Puttfarcken, P. Oxidative stress, glutamate, neurodegeneration disorders, Science, 262 (1993) 689–695.
  8. Evans, M.C., Griffiths, T. and Meldrum, B.S., Kainic acid seizures and the reversibility of calcium loading in vulnerable neurons in the hippocampus, Neuropathol. Appl. Neurobiol., 10 (1984) 285–302.
  9. Hagerdal, M., Welsh, F.A., Keykhah, M., Perez, E. and Harp, J.R., Protective effects of combinations of hypothermia and barbiturates in cerebral hypoxia of the rat, Anesthesiology, 49 (1978) 165–169.
  10. Halliwell, B. and Gutteridge, J.M.C., Oxygen free radicals and iron in relation to biology and medicine: some problems and concepts, Arch. Biochem. Biophys., 246 (1986) 501–514.
  11. Lafon-Cazal, M., Pietri, S., Culcasi, M. and Bockaert, J. NMDA-dependent superoxide production and neurotoxicity. Nature, 364 (1993) 535–537.
  12. Lai, E.K., Crossley, C., Shridar, R., Misra, H.P., Janzen, E.G. and McCay, P.B., In vivo spin trapping of free radicals generated in brain, spleen, and liver during gamma radiation of mice, Arch. Biochem. Biophys., 244 (1986) 156–160.
  13. LeBel, C.P. and Bondy, S. Oxidative damage and cerebral aging. Prog. Neurobiol., 38 (1992) 601–609.
  14. Monyer, H., Hartley, D.M. and Choi, D.W., 21-aminosteroids attenuate excitoxic neuronal injury in cortical cultures, Neuron, 5 (1990) 121–126.
  15. Nakahara, D., Ozaki, N., Miura, Y., Miura, H. and Nagatsu, T., Increased dopamine and serotonin metabolism in rat nucleus accumbens produced by intracranial self-stimulation of medial forebrain bundle as measured by in vivo microdialysis, Brain Res., 495 (1989) 178–181.
  16. Pellegrino, L.J., Pellegrino, A.S. and Cushman, A.J., A Stereotaxic Atlas of the Rat Brain. Plenum Press, New York, 1986.
  17. Schmidley, M.D., Free radicals in central nervous system ischemia, Stroke, 21 (1990) 1086–1090.
  18. Sutherland, G., Bose, R., Louw, D. and Pinsky, C., Global elevation of brain superoxide dismutase activity following forebrain ischemia, Neurosci. Lett., 128 (1991) 169–172.
  19. Takazawa, A., Murashima, Y.L., Minatogawa, Y., Kojima, T., Tanaka, K. and Yamauchi, T., In vivo microdialysis monitoring for extracellular glutamate and GABA in the ventral hippocampus of the awake rat during kainate-induced seizures, Psychiatry Clin. Neurosci., 49 (1995) s275–s277.
  20. Tanaka, T., Tanaka, S., Fujita, T., Takano, K., Fukida, H., Sako, K. and Yonemasu, Y., Experimental complex partial seizures induced by a microinjection of kainic acid into limbic structures, Prog. Neurobiol., 38 (1991) 317–334.
  21. Zini, I., Tomasi, A., Grimaldi, R., Vannini, V. and Agnati, L.F., Detection of free radicals during brain ischemia and reperfusion by spin trapping and microdialysis, Neurosci. Lett., 138 (1992) 279–282.

PII: S0920-1211(96)00901-1

doi: 10.1016/S0920-1211(96)00901-1

Epilepsy Research
Volume 26, Issue 2 , Pages 329-333 , January 1997

Article Tools

* Image Usage & Resolution