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The antiepileptic drug mephobarbital is not transported by P-glycoprotein or multidrug resistance protein 1 at the blood–brain barrier: A positron emission tomography study

  • Severin Mairinger

      Affiliations

    • Health & Environment Department, Molecular Medicine, AIT Austrian Institute of Technology GmbH, Seibersdorf, Austria
    • Department of Medicinal Chemistry, University of Vienna, Austria
    • Department of Clinical Pharmacology, Medical University of Vienna, Austria
    • These two authors contributed equally to this study.
    • ,
  • Jens P. Bankstahl

      Affiliations

    • Department of Pharmacology, Toxicology & Pharmacy, University of Veterinary Medicine, Hannover, Germany
    • Clinic of Nuclear Medicine, Hannover Medical School, Hannover, Germany
    • These two authors contributed equally to this study.
    • ,
  • Claudia Kuntner

      Affiliations

    • Health & Environment Department, Molecular Medicine, AIT Austrian Institute of Technology GmbH, Seibersdorf, Austria
    • ,
  • Kerstin Römermann

      Affiliations

    • Department of Pharmacology, Toxicology & Pharmacy, University of Veterinary Medicine, Hannover, Germany
    • ,
  • Marion Bankstahl

      Affiliations

    • Department of Pharmacology, Toxicology & Pharmacy, University of Veterinary Medicine, Hannover, Germany
    • ,
  • Thomas Wanek

      Affiliations

    • Health & Environment Department, Molecular Medicine, AIT Austrian Institute of Technology GmbH, Seibersdorf, Austria
    • ,
  • Johann Stanek

      Affiliations

    • Health & Environment Department, Molecular Medicine, AIT Austrian Institute of Technology GmbH, Seibersdorf, Austria
    • Department of Clinical Pharmacology, Medical University of Vienna, Austria
    • ,
  • Wolfgang Löscher

      Affiliations

    • Department of Pharmacology, Toxicology & Pharmacy, University of Veterinary Medicine, Hannover, Germany
    • ,
  • Markus Müller

      Affiliations

    • Department of Clinical Pharmacology, Medical University of Vienna, Austria
    • ,
  • Thomas Erker

      Affiliations

    • Department of Medicinal Chemistry, University of Vienna, Austria
    • Corresponding Author InformationCorresponding author at: Department of Medicinal Chemistry, University of Vienna, Austria. Tel.: +43 1 4277 550 03; fax: +43 1 4277 9 551.
    • ,
  • Oliver Langer

      Affiliations

    • Health & Environment Department, Molecular Medicine, AIT Austrian Institute of Technology GmbH, Seibersdorf, Austria
    • Department of Clinical Pharmacology, Medical University of Vienna, Austria

Received 14 November 2011 ,Revised 10 January 2012 ,Accepted 22 January 2012. Published online 20 February 2012 Corrected Proof

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PII: S0920-1211(12)00032-0

doi: 10.1016/j.eplepsyres.2012.01.012

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