Aquaporin-4-dependent edema clearance following status epilepticus

Lee, Darrin J.; Amini, Mariam; Hamamura, Mark J.; Hsu, Mike S.; Seldin, Marcus M.; Nalcioglu, Orhan; Binder, Devin K.

doi:10.1016/j.eplepsyres.2011.09.016

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Volume 98, Issue 2 , Pages 264-268, February 2012

Aquaporin-4-dependent edema clearance following status epilepticus

Darrin J. Lee
- Department of Neurological Surgery, University of California, Davis, CA, United States
Mariam Amini
- University of California, Irvine, CA, United States
Mark J. Hamamura
- Research Imaging Center, University of California, Irvine, CA, United States
Mike S. Hsu
- Center for Glial-Neuronal Interactions, Division of Biomedical Sciences, University of California, Riverside, CA, United States
Marcus M. Seldin
- Department of Physiology, Johns Hopkins University, Baltimore, MD, United States
Orhan Nalcioglu
- Research Imaging Center, University of California, Irvine, CA, United States
Devin K. Binder
- Center for Glial-Neuronal Interactions, Division of Biomedical Sciences, University of California, Riverside, CA, United States
- Corresponding author at: Center for Glial-Neuronal Interactions, Division of Biomedical Sciences, 1247 Webber Hall, University of California, Riverside, CA 92521-0121, United States. Tel.: +1 951 827 2224; fax: +1 951 827 5504.

Received 7 July 2011; received in revised form 6 September 2011; accepted 24 September 2011. published online 14 October 2011.

Summary

We investigated the role of aquaporin-4 in the development of cerebral edema following kainic acid-induced status epilepticus (SE) using specific gravimetry and T2 MRI techniques at 6h, 1 day, 4 days and 7 days after SE. Our results indicate significantly greater tissue edema and T2 MRI changes in AQP4^−/− compared to AQP4^+/+ mice that peaks at about 1 day after SE (greater in hippocampus relative to cortex). These results have implications for the mechanisms of edema formation and clearance following intense seizure activity.