Epilepsy Research
Volume 98, Issue 1 , Pages 25-34 , January 2012

Phenotypic differences between fast and slow methionine sulfoximine-inbred mice: Seizures, anxiety, and glutamine synthetase

  • Arnaud Boissonnet

      Affiliations

    • Laboratoire de Neurobiologie, Rue de Chartres, Université d’Orléans, 45067 Orléans CEDEX 2, France
    • Glycodiag, 520 rue de Champteloup, 45520 Chevilly, France
  • ,
  • Tobias Hévor

      Affiliations

    • Laboratoire de Neurobiologie, Rue de Chartres, Université d’Orléans, 45067 Orléans CEDEX 2, France
  • ,
  • Jean-François Cloix

      Affiliations

    • Laboratoire de Neurobiologie, Rue de Chartres, Université d’Orléans, 45067 Orléans CEDEX 2, France
    • Corresponding Author InformationCorresponding author. Tel.: +33 0 238494979; fax: +33 0 238417244.

Received 9 June 2011 ,Revised 4 August 2011 ,Accepted 18 August 2011.

References 

  1. Andrade DM, Minassian BA. Genetics of epilepsies. Expert Rev. Neurother. 2007;7:727–734
  2. Armijo JA, Shushtarian M, Valdizan EM, Cuadrado A, de las Cuevas I, Adin J. Ion channels and epilepsy. Curr. Pharm. Des. 2005;11:1975–2003
  3. Belzung C, Griebel G. Measuring normal and pathological anxiety-like behaviour in mice: a review. Behav. Brain Res. 2001;125:141–149
  4. Bidmon HJ, Gorg B, Palomero-Gallagher N, Schleicher A, Haussinger D, Speckmann EJ, et al. Glutamine synthetase becomes nitrated and its activity is reduced during repetitive seizure activity in the pentylentetrazole model of epilepsy. Epilepsia. 2008;49:1733–1748
  5. Blin M, Crusio WE, Hevor T, Cloix J-F. Chronic inhibition of glutamine synthetase is not associated with impairment of learning and memory in mice. Brain Res. Bull. 2002;57:11–15
  6. Chapouthier G, Launay JM, Venault P, Breton C, Roubertoux PL, Crusio WE. Genetic selection of mouse lines differing in sensitivity to a benzodiazepine receptor inverse agonist. Brain Res. 1998;787:85–90
  7. Cloix JF, Hevor T. Epilepsy, regulation of brain energy metabolism and neurotransmission. Curr. Med. Chem. 2009;16:841–853
  8. Cloix JF, Tahi Z, Boissonnet A, Hevor T. Brain glycogen and neurotransmitter levels in fast and slow methionine sulfoximine-selected mice. Exp. Neurol. 2010;225:38–47
  9. Cloix JF, Tahi Z, Martin B, Hevor T. Selection of two lines of mice based on latency to onset of methionine sulfoximine seizures. Epilepsia. 2010;51:118–128
  10. Crusio WE. Genetic dissection of mouse exploratory behaviour. Behav. Brain Res. 2001;125:127–132
  11. Dalsgaard MK, Madsen FF, Secher NH, Laursen H, Quistorff B. High glycogen levels in the hippocampus of patients with epilepsy. J. Cereb. Blood Flow Metab. 2007;27:1137–1141
  12. Duvoisin RM, Pfankuch T, Wilson JM, Grabell J, Chhajlani V, Brown DG, et al. Acute pharmacological modulation of mGluR8 reduces measures of anxiety. Behav. Brain Res. 2010;212:168–173
  13. Eid T, Ghosh A, Wang Y, Beckstrom H, Zaveri HP, Lee TS, et al. Recurrent seizures and brain pathology after inhibition of glutamine synthetase in the hippocampus in rats. Brain. 2008;131:2061–2070
  14. Einat H, Manji HK, Gould TD, Du J, Chen G. Possible involvement of the ERK signaling cascade in bipolar disorder: behavioral leads from the study of mutant mice. Drug News Perspect. 2003;16:453–463
  15. Engelsen B, Fonnum F. The effect of methionine sulfoximine, an inhibitor of glutamine synthetase, on the levels of amino acids in the intact and decorticated rat neostriatum. Brain Res. 1985;338:165–168
  16. Folbergrova J, Passonneau JV, Lowry OH, Schulz DW. Glycogen, ammonia and related metabolites in the brain during seizures evoked by methionine sulphoximine. J. Neurochem. 1969;16:191–203
  17. Fonnum F, Paulsen RE. Comparison of transmitter amino acid levels in rat globus pallidus and neostriatum during hypoglycemia or after treatment with methionine sulfoximine or gamma-vinyl gamma-aminobutyric acid. J. Neurochem. 1990;54:1253–1257
  18. Griffith OW, Meister A. Differential inhibition of glutamine and gamma-glutamylcysteine synthetases by alpha-alkyl analogs of methionine sulfoximine that induce convulsions. J. Biol. Chem. 1978;253:2333–2338
  19. Guillot PV, Sluyter F, Crusio WE, Chapouthier G. Mice selected for differences in sensitivity to a benzodiazepine receptor inverse agonist vary in intermale aggression. Neurogenetics. 1999;2:171–175
  20. Hashimoto K, Sawa A, Iyo M. Increased levels of glutamate in brains from patients with mood disorders. Biol. Psychiatry. 2007;62:1310–1316
  21. Hevor TK. Some aspects of carbohydrate metabolism in the brain. Biochimie. 1994;76:111–120
  22. Hixson JD, Kirsch HE. The effects of epilepsy and its treatments on affect and emotion. Neurocase. 2009;15:206–216
  23. Kanner AM. The use of psychotropic drugs in epilepsy: what every neurologist should know. Semin. Neurol. 2008;28:379–388
  24. Kanner AM. Psychiatric issues in epilepsy: the complex relation of mood, anxiety disorders, and epilepsy. Epilepsy Behav. 2009;15:83–87
  25. Krystal JH, Mathew SJ, D'Souza DC, Garakani A, Gunduz-Bruce H, Charney DS. Potential psychiatric applications of metabotropic glutamate receptor agonists and antagonists. CNS Drugs. 2010;24:669–693
  26. LaFrance WC, Kanner AM, Hermann B. Psychiatric comorbidities in epilepsy. Int. Rev. Neurobiol. 2008;83:347–383
  27. Lowry OH, Rosebrough NJ, Farr AL, Randall RJ. Protein measurement with the Folin phenol reagent. J. Biol. Chem. 1951;193:265–275
  28. Mares P, Mikulecka A, Ticha K, Lojkova-Janeckova D, Kubova H. Metabotropic glutamate receptors as a target for anticonvulsant and anxiolytic action in immature rats. Epilepsia. 2010;51(Suppl. 3):24–26
  29. Martinez-Hernandez A, Bell KP, Norenberg MD. Glutamine synthetase: glial localization in brain. Science. 1977;195:1356–1358
  30. McNamara JO, Huang YZ, Leonard AS. Molecular signaling mechanisms underlying epileptogenesis. Sci. STKE. 2006;2006:re12
  31. Meldrum B. Status epilepticus: the past and the future. Epilepsia. 2007;48(Suppl. 8):33–34
  32. Mohler H. GABAA receptors in central nervous system disease: anxiety, epilepsy, and insomnia. J. Recept. Signal Transduct. Res. 2006;26:731–740
  33. Moult PR. Neuronal glutamate and GABAA receptor function in health and disease. Biochem. Soc. Trans. 2009;37:1317–1322
  34. Mula M, Monaco F. Antiepileptic drugs and psychopathology of epilepsy: an update. Epileptic Disord. 2009;11:1–9
  35. Phelps CH. An ultrastructural study of methionine sulphoximine-induced glycogen accumulation in astrocytes of the mouse cerebral cortex. J. Neurocytol. 1975;4:479–490
  36. Racine RJ. Modification of seizure activity by electrical stimulation. II. Motor seizure. Electroencephalogr. Clin. Neurophysiol. 1972;32:281–294
  37. Reid CA, Berkovic SF, Petrou S. Mechanisms of human inherited epilepsies. Prog. Neurobiol. 2009;87:41–57
  38. Rossler AS, Schroder H, Dodd RH, Chapouthier G, Grecksch G. Benzodiazepine receptor inverse agonist-induced kindling of rats alters learning and glutamate binding. Pharmacol. Biochem. Behav. 2000;67:169–175
  39. Scharfman HE. The neurobiology of epilepsy. Curr. Neurol. Neurosci. Rep. 2007;7:348–354
  40. Schmidt D. Drug treatment of epilepsy: options and limitations. Epilepsy Behav. 2009;15:56–65
  41. Sierra-Paredes G, Sierra-Marcuno G. Extrasynaptic GABA and glutamate receptors in epilepsy. CNS Neurol. Disord. Drug Targets. 2007;6:288–300
  42. Somers DL, Beckstead RM. Chronic methionine sulfoximine administration reduces synaptosomal aspartate and glutamate in rat striatum. Neurosci. Lett. 1990;115:335–340
  43. Stafstrom CE. Epilepsy: a review of selected clinical syndromes and advances in basic science. J. Cereb. Blood Flow Metab. 2006;26:983–1004
  44. Velisek L, Veresova S, Pobisova H, Mares P. Excitatory amino acid antagonists and pentylenetetrazol-induced seizures during ontogenesis. II. The effects of MK-801. Psychopharmacology (Berl). 1991;104:510–514
  45. Venault P, Beracochea D, Valleau M, Joubert C, Chapouthier G. Mouse lines selected for difference in sensitivity to beta-CCM also differ in memory processes. Behav. Brain Res. 2006;173:282–287
  46. Venault P, Chapouthier G. Plasticity and anxiety. Neural Plast. 2007;2007:75617
  47. Vincent P, Mulle C. Kainate receptors in epilepsy and excitotoxicity. Neuroscience. 2009;158:309–323
  48. Wieronska JM, Pilc A. Metabotropic glutamate receptors in the tripartite synapse as a target for new psychotropic drugs. Neurochem. Int. 2009;55:85–97
  49. Wolfe LS, Elliot KAC. Chemical studies in regulation to convulsive conditions. In:  Elliot KAC,  Page IH,  Quastel JH editor. Neurochemistry. 2nd ed.. USA: Springfield; 1962;p. 694–697

PII: S0920-1211(11)00236-1

doi: 10.1016/j.eplepsyres.2011.08.012

Epilepsy Research
Volume 98, Issue 1 , Pages 25-34 , January 2012