Epilepsy Research
Volume 91, Issue 1 , Pages 84-93 , September 2010

Expression patterns of AMOG in developing human cortex and malformations of cortical development

  • K. Boer

      Affiliations

    • Department of (Neuro)Pathology, Academic Medical Center, University of Amsterdam, The Netherlands
    • ,
  • W.G.M. Spliet

      Affiliations

    • Department of Pathology, Rudolf Magnus Institute for Neurosciences, University Medical Center Utrecht, The Netherlands
    • ,
  • P.C. van Rijen

      Affiliations

    • Department of Neurosurgery, Rudolf Magnus Institute for Neurosciences, University Medical Center Utrecht, The Netherlands
    • ,
  • F.E. Jansen

      Affiliations

    • Department of Child Neurology, Rudolf Magnus Institute for Neurosciences, University Medical Center Utrecht, The Netherlands
    • ,
  • E. Aronica

      Affiliations

    • Department of (Neuro)Pathology, Academic Medical Center, University of Amsterdam, The Netherlands
    • Epilepsy Institute of The Netherlands (SEIN), Heemstede, The Netherlands
    • Corresponding Author InformationCorresponding author at: Department of (Neuro)Pathology, Academic Medical Center, Meibergdreef 9, 1105 AZ Amsterdam, The Netherlands. Tel.: +31 20 5662943; fax: +31 20 5669522.

Received 30 April 2010 ,Revised 13 June 2010 ,Accepted 29 June 2010.

References 

  1. Antonicek H, Persohn E, Schachne M. Biochemical and functional characterization of a novel neuron–glia adhesion molecule that is involved in neuronal migration. J. Cell Biol. 1997;104:1587–1595
  2. Aperia A. New roles for an old enzyme: Na,K-ATPase emerges as an interesting drug target. J. Intern. Med. 2007;261:44–52
  3. Aronica E, Boer K, Redeker S, van Rijen PC, Troost D, Gorter JA. Differential expression patterns of Chloride transporters, NKCC1 and KCC2, in epilepsy-associated malformations of cortical development. Neuroscience. 2007;145:185–196
  4. Barkovich AJ, Kuzniecky RI, Jackson GD, Guerrini R, Dobyns WB. A developmental and genetic classification for malformations of cortical development. Neurology. 2005;65:1873–1887
  5. Baybis M, Yu J, Lee A, Golden JA, Weiner H, McKhann G, et al. mTOR cascade activation distinguishes tubers from focal cortical dysplasia. Ann. Neurol. 2004;56:478–487
  6. Becker AJ, Blumcke I, Urbach H, Hans V, Majores M. Molecular neuropathology of epilepsy-associated glioneuronal malformations. J. Neuropathol. Exp. Neurol. 2006;65:99–108
  7. Blümcke I. Neuropathology of focal epilepsies: a critical review. Epilepsy Behav. 2009;15:34–39
  8. Blümcke I, Giencke K, Wardelmann E, Beyenburg S, Kral T, Sarioglu N, et al. The CD34 epitope is expressed in neoplastic and malformative lesions associated with chronic, focal epilepsies. Acta Neuropathol. 1999;97:481–490
  9. Blümcke I, Vinters HV, Armstrong D, Aronica E, Thom M, Spreafico R. Malformations of cortical development and epilepsies: neuropathological findings with emphasis on focal cortical dysplasia. Epileptic Dis. 2009;11:181–193
  10. Boer, K., Crino, P.B., Gorter, J.A., Nellist, M., Jansen, F.E., Spliet, W.G., van Rijen, P.C., Wittink, F., Breit, T., Troost, D., Wadman, W.J., Aronica, E., 2009. Gene expression analysis of tuberous sclerosis complex cortical tubers reveals increased expression of adhesion and inflammatory factors. Brain Pathol. [Epub ahead of print].
  11. Boer K, Troost D, Timmerman W, Spliet WGM, van Rijen PC, Aronica E. Pi3K–mTOR signaling and AMOG expression in epilepsy-associated glioneuronal tumors. Brain Pathol. 2010;20(1):234–244
  12. Boer K, Troost D, Timmermans W, Gorter JA, Spliet WG, Nellist M, et al. Cellular localization of metabotropic glutamate receptors in cortical tubers and subependymal giant cell tumors of tuberous sclerosis complex. Neuroscience. 2008;156:203–215
  13. Celio MR, Blümcke I. Perineuronal nets—a specialized form of extracellular matrix in the adult nervous system. Brain Res.: Brain Res. Rev. 1994;19:128–145
  14. D’Ambrosio R, Gordon DS, Winn HR. Differential role of KIR channel and Na(+)/K(+)-pump in the regulation of extracellular K(+) in rat hippocampus. J. Neurophysiol. 2002;87:87–102
  15. de Groot M, Toering ST, Boer K, Spliet WG, Heimans JJ, Aronica E, et al. Expression of synaptic vesicle protein 2A in epilepsy-associated brain tumors and in the peritumoral cortex. Neuro Oncol. 2010;12:265–273
  16. de Vries B, Stam AH, Kirkpatrick M, Vanmolkot KR, Koenderink JB, van den Heuvel JJ, et al. Familial hemiplegic migraine is associated with febrile seizures in an FHM2 family with a novel de novo ATP1A2 mutation. Epilepsia. 2009;50:2503–2504
  17. Fauser S, Becker A, Schulze-Bonhage A, Hildebrandt M, Tuxhorn I, Pannek HW, et al. CD34-immunoreactive balloon cells in cortical malformations. Acta Neuropathol. 2004;108:272–278
  18. Gallanti A, Tonelli A, Cardin V, Bussone G, Bresolin N, Bassi MT. A novel de novo nonsense mutation in ATP1A2 associated with sporadic hemiplegic migraine and epileptic seizures. J. Neurol. Sci. 2008;273:123–126
  19. Gloor S, Antonicek H, Sweadner KJ, Pagliusi S, Frank R, al MMe. The adhesion molecule on glia (AMOG) is a homologue of the beta subunit of the Na,K-ATPase. J. Cell Biol. 1990;110:165–174
  20. Gloor SM. Relevance of Na,K-ATPase to local extracellular potassium homeostasis and modulation of synaptic transmission. FEBS Lett. 1997;412:104
  21. Gomez M, Sampson J, Whittemore V. The Tuberous Sclerosis Complex. Oxford: Oxford University Press; 1999;
  22. Grisar T, Guillaume D, Delgado-Escueta AV. Contribution of Na+,K(+)-ATPase to focal epilepsy: a brief review. Epilepsy Res. 1992;12:141–149
  23. Ikeda K, Onimaru H, Yamada J, Inoue K, Ueno S, Onaka T, et al. Malfunction of respiratory-related neuronal activity in Na+, K+-ATPase alpha2 subunit-deficient mice is attributable to abnormal Cl− homeostasis in brainstem neurons. J. Neurosci. 2004;24:10693–10701
  24. Lecuona E, Luquin S, Avila J, Garcia-Segura LM, Martin-Vasallo P. Expression of the beta 1 and beta 2(AMOG) subunits of the Na,K-ATPase in neural tissues: cellular and developmental distribution patterns. Brain Res. Bull. 1996;40:167–174
  25. Magyar JP, Bartsch U, Wang ZQ, Howells N, Aguzzi A, Wagner EF, et al. Degeneration of neural cells in the central nervous system of mice deficient in the gene for the adhesion molecule on Glia, the beta 2 subunit of murine Na,K-ATPase. J. Cell Biol. 1994;127:835–845
  26. Magyar JP, Schachner M. Genomic structure of the adhesion molecule on glia (AMOG, Na/K-ATPase beta 2 subunit). Nucleic Acids Res. 1990;18:6695–6696
  27. McGrail KM, Phillips JM, Sweadner KJ. Immunofluorescent localization of three Na,K-ATPase isozymes in the rat central nervous system: both neurons and glia can express more than one Na,K-ATPase. J. Neurosci. 1991;11:381–391
  28. Miyata H, Chiang AC, Vinters HV. Insulin signaling pathways in cortical dysplasia and TSC-tubers: tissue microarray analysis. Ann. Neurol. 2004;56:510–519
  29. Muller-Husmann G, Gloor S, Schachner M. Functional characterization of beta isoforms of murine Na,K-ATPase. The adhesion molecule on glia (AMOG/beta 2), but not beta 1, promotes neurite outgrowth. J. Biol. Chem. 1993;268:26260–26267
  30. Najm IM, Tilelli CQ, Oghlakian R. Pathophysiological mechanisms of focal cortical dysplasia: a critical review of human tissue studies and animal models. Epilepsia. 2007;48(Suppl. 2):21–32
  31. Orlova KA, Crino PB. The tuberous sclerosis complex. Ann. N.Y. Acad. Sci. 2010;1184:87–105
  32. Pagliusi SR, Schachner M, Seeburg PH, Shivers BD. The adhesion molecule on glia (AMOG) is widely expressed by astrocytes in developing and adult mouse brain. Eur. J. Neurosci. 1990;2:471–480
  33. Palmini A, Najm I, Avanzini G, Babb T, Guerrini R, Foldvary-Schaefer N, et al. Terminology and classification of the cortical dysplasias. Neurology. 2004;62:S2–S8
  34. Pietrobon D. Migraine: new molecular mechanisms. Neuroscientist. 2005;11:373–386
  35. Rivera C, Voipio J, Payne JA, Ruusuvuori E, Lahtinen H, Lamsa K, et al. The K+/Cl− co-transporter KCC2 renders GABA hyperpolarizing during neuronal maturation. Nature. 1999;397:251–255(see comment)
  36. Scheidenhelm DK, Cresswell J, Haipek CA, Fleming TP, Mercer RW, Gutmann DH. Akt-dependent cell size regulation by the adhesion molecule on glia occurs independently of phosphatidylinositol 3-kinase and Rheb signaling. Mol. Cell. Biol. 2005;25:3151–3162
  37. Schick V, Majores M, Engels G, Hartmann W, Elger CE, Schramm J, et al. Differential Pi3K-pathway activation in cortical tubers and focal cortical dysplasias with balloon cells. Brain Pathol. 2007;17:165–173
  38. Schick V, Majores M, Koch A, Elger CE, Schramm J, Urbach H, et al. Alterations of phosphatidylinositol 3-kinase pathway components in epilepsy-associated glioneuronal lesions. Epilepsia. 2007;48(Suppl. 5):65–73
  39. Senner V, Schmidtpeter S, Braune S, Puttmann S, Thanos S, Bartsch U, et al. AMOG/beta2 and glioma invasion: does loss of AMOG make tumour cells run amok?. Neuropathol. Appl. Neurobiol. 2003;29:370–377
  40. Smith PK, Krohn RI, Hermanson GT, Mallia AK, Gartner FH, Provenzano MD, et al. Measurement of protein using bicinchoninic acid. Anal. Biochem. 1985;150:76–85
  41. Sweadner KJ. Isozymes of the Na+/K+-ATPase. Biochem. Biophys. Acta. 1989;988:185–220
  42. Toering ST, Boer K, de Groot M, Troost D, Heimans JJ, Spliet WG, et al. Expression patterns of synaptic vesicle protein 2A in focal cortical dysplasia and TSC-cortical tubers. Epilepsia. 2009;50:1409–1418
  43. Wong M. Mechanisms of epileptogenesis in tuberous sclerosis complex and related malformations of cortical development with abnormal glioneuronal proliferation. Epilepsia. 2008;49:8–21

PII: S0920-1211(10)00162-2

doi: 10.1016/j.eplepsyres.2010.06.015

Epilepsy Research
Volume 91, Issue 1 , Pages 84-93 , September 2010

Article Tools

* Image Usage & Resolution