Epilepsy Research
Volume 91, Issue 1 , Pages 74-83 , September 2010

Brivaracetam does not alter spatial learning and memory in both normal and amygdala-kindled rats

  • E.R. Detrait

      Affiliations

    • UCB Pharma S.A., CNS Research, Chemin du Foriest, B-1420 Braine-l’Alleud, Belgium
    • Corresponding Author InformationCorresponding author at: UCB Pharma S.A., CNS Research - In vivo Pharmacology Dpt, R9 Building, Chemin du Foriest, B-1420 Braine-l’Alleud, Belgium. Tel.: +32 2 386 6196; fax: +32 02 386 3141.
    • ,
  • K. Leclercq

      Affiliations

    • UCB Pharma S.A., CNS Research, Chemin du Foriest, B-1420 Braine-l’Alleud, Belgium
    • ,
  • W. Löscher

      Affiliations

    • Department of Pharmacology, Toxicology, and Pharmacy, University of Veterinary Medicine Hannover, and Center for Systems Neuroscience, Bünteweg 17, 30559 Hannover, Germany
    • ,
  • H. Potschka

      Affiliations

    • Department of Pharmacology, Toxicology, and Pharmacy, University of Veterinary Medicine Hannover, and Center for Systems Neuroscience, Bünteweg 17, 30559 Hannover, Germany
    • ,
  • I. Niespodziany

      Affiliations

    • UCB Pharma S.A., CNS Research, Chemin du Foriest, B-1420 Braine-l’Alleud, Belgium
    • ,
  • E. Hanon

      Affiliations

    • UCB Pharma S.A., CNS Research, Chemin du Foriest, B-1420 Braine-l’Alleud, Belgium
    • ,
  • R.M. Kaminski

      Affiliations

    • UCB Pharma S.A., CNS Research, Chemin du Foriest, B-1420 Braine-l’Alleud, Belgium
    • ,
  • A. Matagne

      Affiliations

    • UCB Pharma S.A., CNS Research, Chemin du Foriest, B-1420 Braine-l’Alleud, Belgium
    • ,
  • Y. Lamberty

      Affiliations

    • UCB Pharma S.A., CNS Research, Chemin du Foriest, B-1420 Braine-l’Alleud, Belgium

Received 26 February 2010 ,Revised 25 June 2010 ,Accepted 29 June 2010.

References 

  1. Bliss TVP, Collingridge GL. A synaptic model of memory: long-term potentiation in the hippocampus. Nature. 1993;361:31–39
  2. Carreno M, Donaire A, Sanchez-Carpintero S. Cognitive disorders associated with epilepsy: diagnosis and treatment. Neurologist. 2008;14:S26–S34
  3. Churchill JD, Fang PC, Voss SE, Besheer J, Herron AL, Garraghty PE. Some antiepileptic compounds impair learning by rats in a Morris water maze. Integr. Physiol. Behav. Sci. 2003;38(2):91–103
  4. Cunha AO, Mortari MR, Liberato JL, dos Santos WF. Neuroprotective effects of diazepam, carbamazepine, phenytoin and ketamine after pilocarpine-induced status epilepticus. Basic Clin. Pharmacol. Toxicol. 2009;104:470–477
  5. Davis S, Butcher SP, Morris RG. The NMDA receptor antagonist D-2-aminophosphonopentanoate (D-AP5) impairs spatial learning and LTP in vivo at intracerebral concentrations comparable to those that block LTP in vitro. J. Neurosci. 1992;12:21–34
  6. Frisch C, Kudin AP, Elger CE, Kunz WS, Helmstaedter C. Amelioration of water maze performance deficits by topiramate applied during pilocarpine-induced status epilepticus is negatively dose-dependent. Epilepsy Res. 2007;73(2):173–180
  7. Gastens AM, Brandt C, Bankstahl JP, Löscher W. Predictors of pharmacoresistant epilepsy: pharmacoresistant rats differ from pharmacoresponsive rats in behavioral and cognitive abnormalities associated with experimentally induced epilepsy. Epilepsia. 2008;49(10):1759–1776
  8. Hessen E, Lossius MI, Reinvang I, Gjerstad L. Influence of major antiepileptic drugs on attention, reaction time, and speed of information processing: results from a randomized, double-blind, placebo controlled withdrawal study of seizure-free epilepsy patients receiving monotherapy. Epilepsia. 2006;47(12):2038–2045
  9. Hönack D, Löscher W. Kindling increases the sensitivity of rats to adverse effects of certain antiepileptic drugs. Epilepsia. 1995;36:763–771
  10. Kaminski RM, Gillard M, Leclercq K, Hanon E, Lorent G, Dassesse D, et al. Proepileptic phenotype of SV2A-deficient mice is associated with reduced anticonvulsant efficacy of levetiracetam. Epilepsia. 2009;50:1729–1740
  11. Kaminski RM, Leclercq K, Matagne A, Klitgaard H. Protective activity of brivaracetam in the 6Hz model of partial epilepsy: comparison with levetiracetam and older antiepileptic drugs. Epilepsia. 2008;49(Suppl. 7):111
  12. Kaminski RM, Matagne A, Klitgaard H. Brivaracetam displays seizure protection superior to levetiracetam in phenytoin-resistant amygdala-kindled mice. Epilepsia. 2008;49(Suppl. 7):115
  13. Kenda BM, Matagne AC, Talaga PE, Pasau PM, Differding E, Lallemand BI, et al. Discovery of 4-substituted pyrrolidone butanamides as new agents with significant antiepileptic activity. J. Med. Chem. 2004;47(3.):530–549
  14. Klitgaard A, Matagne A, Lamberty Y. Use of epileptic animals for adverse effect testing. Epilepsy Res. 2002;50:55–65
  15. Klitgaard H, Matagne A, Gobert J, Wulfert E. Evidence for a unique preclinical profile of levetiracetam in rodents models of seizure and epilepsy. Eur. J. Pharmacol. 1998;353:191–206
  16. Lamberty Y, Margineanu DG, Klitgaard H. Absence of negative impact of Levetiracetam on cognitive function and memory in normal and amygdala-kindled rats. Epilepsy Behav. 2000;1:333–342
  17. Laveille C, Lacroix B, Snoeck E, Sargentini-Maier ML, von Rosenstiel P, Stockis A. Dose- and exposure-response modeling of brivaracetam add-on treatment in patients with partial epilepsy. Epilepsia. 2007;48(Suppl. 6):328
  18. Lee GYP, Brown LM, Teyler TJ. The effects of anticonvulsant drugs on long–term potentiation (LTP) in the rat hippocampus. Brain Res. Bull. 1996;39:39–42
  19. Levisohn PM, Mintz M, Hunter SJ, Yang H, Jones J. Neurocognitive effects of adjunctive levetiracetam in children with partial-onset seizures: a randomized, double-blind, placebo-controlled, non inferiority trial. Epilepsia. 2009;50(11):2377–2389
  20. Löscher W, Hönack D. Profile of ucb L059, a novel anticonvulsant drug, in models of partial and generalized epilepsy in mice and rats. Eur. J. Pharmacol. 1993;232:147–158
  21. Löscher W, Jäckel R, Czuczwar SJ. Is amygdala kindling in rat a model for drug-resistant partial epilepsy?. Exp. Neurol. 1986;93:211–226
  22. Lynch BA, Lambeng N, Nocka K, Kensel-Hammes P, Bajjalieh SM, Matagne A, et al. The synaptic vesicle protein SV2A is the binding site for the antiepileptic drug levetiracetam. Proc. Natl. Acad. Sci. U.S.A. 2004;101(26):9861–9866
  23. Margineanu DG, Niespodziany I, Wülfert E. Hippocampal slices from long-term streptozotocin-injected rats are prone to epileptiform responses. Neurosci. Lett. 1998;252:183–186
  24. Matagne A, Margineanu DG, Kenda B, Michel P, Klitgaard H. Anti-convulsive and anti-epileptic properties of brivaracetam (ucb 34714), a high-affinity ligand for the synaptic vesicle protein, SV2A. Br. J. Pharmacol. 2008;154(8):1662–1671
  25. McDaniel WF, Sawitsky AS, Vick KE. Topiramate attenuates a transient learning deficit after lesions inducing intracerebral hemorrhage. Psychol. Rep. 2007;100:164–166
  26. Mula M, Trimble MR. Antiepileptic drug-induced cognitive adverse effects. CNS Drugs. 2009;23(2):121–137
  27. Ortinski P, Meador KJ. Cognitive side effects of antiepileptic drugs. Epilepsy Behav. 2004;5:S60–S65
  28. Paxinos G, Watson C. The Rat Brain in Stereotaxic Coordinates. Australia: Academic Press; 1982;
  29. Racine RJ. Modification of seizure activity by electrical stimulation. II. Motor seizure. Electroencephalogr. Clin. Neurophysiol. 1972;32:295–299
  30. Schmitt U, Hiemke C. Tiagabine, a gammaamino-butyric acid transporter impairs spatial learning of rats in the Morris water maze. Behav. Brain Res. 2002;18(133):391–394
  31. Steidl EM, Neveu E, Bertrand D, Buisson B. The adult rat hippocampal slice revisited with multi-electrode arrays. Brain Res. 2006;1096:70–84
  32. Zhou JL, Zhao Q, Holmes GL. Effect of levetiracetam on visual–spatial memory following status epilepticus. Epilepsy Res. 2007;73(1):65–74
  33. Zona C, Pieri M, Carunchio I, Curcio L, Klitgaard H, Margineanu D. Brivaracetam (ucb 34714) inhibits Na+ currents in rat cortical neurons in culture. Epilepsy Res. 2010;88:46–54

PII: S0920-1211(10)00161-0

doi: 10.1016/j.eplepsyres.2010.06.014

Epilepsy Research
Volume 91, Issue 1 , Pages 74-83 , September 2010

Article Tools

* Image Usage & Resolution