Epilepsy Research
Volume 91, Issue 1 , Pages 66-73 , September 2010

Autonomic and cellular mechanisms mediating detrimental cardiac effects of status epilepticus

  • Steven L. Bealer

      Affiliations

    • Department of Pharmacology and Toxicology, College of Pharmacy, University of Utah, Salt Lake City, UT 84121, United States
    • Corresponding Author InformationCorresponding author at: Department of Pharmacology and Toxicology, University of Utah, 30 South 2000 East Rm 201, Salt Lake City, UT 84121, United States. Tel.: +1 801 587 7706; fax: +1 801 585 5111.
  • ,
  • Jason G. Little

      Affiliations

    • Department of Pharmacology and Toxicology, College of Pharmacy, University of Utah, Salt Lake City, UT 84121, United States
  • ,
  • Cameron S. Metcalf

      Affiliations

    • Department of Pharmacology and Toxicology, College of Pharmacy, University of Utah, Salt Lake City, UT 84121, United States
  • ,
  • Amy L. Brewster

      Affiliations

    • Departments of Pediatrics, Neurology, and Neuroscience, Baylor College of Medicine, Houston, TX 77030, United States
  • ,
  • Anne E. Anderson

      Affiliations

    • Departments of Pediatrics, Neurology, and Neuroscience, Baylor College of Medicine, Houston, TX 77030, United States

Received 1 April 2010 ,Revised 9 June 2010 ,Accepted 23 June 2010.

References 

  1. Antman EM. Decision making with cardiac troponin tests. N. Engl. J. Med. 2002;346:2079–2082
  2. Barnwell LF, Lugo JN, Lee WL, Willis SE, Gertz SE, Hrachovy RA, et al. Kv4.2 knockout mice demonstrate increased susceptibility to convulsant stimulation. Epilepsia. 2009;50:1741–1751
  3. Birnbaum SG, Varga AW, Yuan L-L, Andersen AE, Sweatt JD, Schraeder LA. Structure and function of the Kv4-family of transient potassium channels. Physiol. Rev. 2004;84:803–833
  4. Boggs JG, Painter JA, DeLorenzo RJ. Analysis of electrocardiographic changes in status epilepticus. Epilepsy Res. 1993;14:87–94
  5. Boggs JG, Marmarou A, Agnew JP, Morton LD, Towne AR, Waterhouse EJ, et al. Hemodynamic monitoring prior to and at the time of death in status epilepticus. Epilepsy Res. 1998;31:199–209
  6. Bolli R. Mechanisms of myocardial “stunning”. Circulation. 1990;82:173–738
  7. Chen L, Wang L, Xu B, Ni G, Yu L, Han B, et al. Mechanisms of alpha1-adrenoceptor mediated QT prolongation in the diabetic rat heart. Life Sci. 2009;84:250–256
  8. Chugh SS, Reiner K, Singh T, Uy-Evanado A, Socoteanu C, Peters D, et al. Determinants of prolonged QT interval and their contribution to sudden death risk in coronary artery disease: the Oregon sudden unexpected death study. Circulation. 2009;119:663–670
  9. Darbar D, Luck J, Davidson N, Pringle T, Main G, McNeill G, et al. Sensitivity and specificity of QTc dispersion for identification of risk of cardiac death in patients with peripheral vascular disease. BMJ. 1996;312:874–878
  10. De Sarro G, Di Paola ED, Ferreri G, De Sarro A, Fishcher W. Influence of some beta-adrenoceptor antagonists on the anticonvulsant potency of antiepileptic drugs against audiogenic seizures in DBA/2 mice. Eur. J. Pharmacol. 2002;442:205–213
  11. DeLorenzo RJ, Towne AR, Pellock JM, Ko D. Status epilepticus in children, adults and the elderly. Epilepsia. 1992;33(Suppl. 4):S15–S25
  12. Gao WD, Atar D, Backx PH, Marban E. Relationship between intracellular calcium and contractile force in stunned myocardium. Direct evidence for decreased myofilament Ca2+ responsiveness and altered diastolic function in intact ventricular muscle. Circ. Res. 1995;76:1036–1048
  13. Glein M, Brandt B, Potschke P, Voigt H, Ebert U, Loscher W. Repeated low dose treatment of rats with pilocarpine: low mortality but high proportion of rats developing epilepsy. Epilepsy Res. 2001;46:111–119
  14. Goodman JH, Homan RW, Crawford IL. Kindled seizures elevate blood pressure and induce cardiac arrhythmias. Epilepsia. 1990;31:489–495
  15. Grippo AJ, Santos CM, Johnson RF, Beltz TG, Martins JB, Felder RB, et al. Increased susceptibility to ventricular arrhythmias in a rodent model of experimental depression. Am. J. Physiol. 2004;286:H619–H626
  16. Ishiguro Y, Morgan JP. Effect of endogenous catecholamine on myocardial stunning in a simulated ischemia model. Fundam. Clin. Pharmacol. 2001;15:111–116
  17. Johnston SC, DSiedenberg R, Min JK, Jerome EH, Laxer KD. Central apnea and acute cardiac ischemia in a sheep model of epileptic sudden death. Ann. Neurol. 1997;42:588–594
  18. Kaprielian R, Wickenden AD, Kassiri Z, Parker TG, Liu PP, Backx PH. Relationship between K+ channel down-regulation and [Ca2+]i in rat ventricular myocytes following myocardial infarction. J. Physiol. 1999;517:229–245
  19. Kassiri Z, Zobel C, Nguyen TT, Molkentin JD, Backx PH. Reduction of I(to) causes hypertrophy in neonatal rat ventricular myocytes. Circ. Res. 2002;90:578–585
  20. Kloner RA, Jennings DB. Consequences of brief ischemia: stunning, preconditioning, and their clinical implications. Circulation. 2001;104:3158–3167
  21. Kulkarni SK, George B. Lithium-pilocarpine neurotoxicity: a potential model of status epilepticus. Methods Find. Exp. Clin. Pharamacol. 1995;17:551–567
  22. Kurata M, Iidaka T, Sasayama Y, Fukushima T, Sakimura M, Shirai N. Correlation among clinicopathological parameters of myocardial damage in rats treated with isoproterenol. Exp. Anim. 2007;56:57–62
  23. Legriel S, Bruneel F, Dalle L, Apere-de-Vecchi C, Georges JL, Abbosh N, et al. Recurrent Takotsubo cardiomyopathy triggered by convulsive status epilepticus. Neurocrit. Care. 2008;9:118–121
  24. Logroscino G, Hesdorffer DC, Cascino G, Hauser WA, Coeytaux A, Glalobardes B, et al. Mortality after a first episode of status epilepticus in the United States and Europe. Epilepsia. 2005;46:46–48
  25. London B, Baker LC, Petkova-Kirova P, Nerbonne JM, Choi BR, Salama G. Dispersion of repolarization and refractoriness are determinants of arrhythmia phenotype in transgenic mice with long QT. J. Physiol. 2007;578:115–129
  26. Lowenstein DH, Alldredge BK. Status epilepticus. N. Engl. J. Med. 1998;338:970–976
  27. Luchowska E, Luchowska P, Wielosz M, Kleinrok Z, Urbanska EM. beta-adrenoceptor blockade enhances the anticonvulsant effect of glutamate receptor antagonists against maximal electroshock. Eur. J. Pharmacol. 2001;431:209–214
  28. Luchowska E, Luchowska P, Wielosz M, Kleinrok Z, Czuczwar SJ, Urbanska EM. Propranolol and metopropolol enhance the anticonvulsant action of valproate and diazepam against maximal electroshock. Pharmacol. Biochem. Behav. 2002;71:223–231
  29. Lugo JN, Barnwell LF, Ren Y, Lee WL, Johnston LD, Kim R, et al. Altered phosphorlyation and localization of the A-type channel, Kv4.2 in status epilepticus. J. Neurochem. 2008;106:1929–1940
  30. Metcalf CS, Poelzing S, Little JG, Bealer SL. Status epilepticus induces cardiac myofilament damage and increased susceptibility to arrhythmias in rat. Am. J. Physiol. 2009;297:H2120–H2127
  31. Nakamura T, Oda Y, Takahashi R, Tanaka K, Hase I, Asada A. Propranolol increases the threshold for lidocaine-induced convulsions in awake rats: a direct effect on the brain. Anesth. Analg. 2008;106:1450–1455
  32. O’Brien PJ, Smith DEC, Knechtel TJ, Marchak MA, Pruimboom-Brees I, Brees DJ, et al. Cardiac troponin I is a sensitive, specific biomarker of cardiac injury in laboratory animals. Lab. Anim. 2006;40:153–171
  33. Painter JA, Shiel FO, DeLorenzo RJ. Cardiac pathology findings in status epilepticus. Epilepsia. 1993;34(Suppl. 6):30
  34. Racine RJ. Modification of seizure activity by electrical stimulation. II. Motor seizure. Electroencephalogr. Clin. Neurophysiol. 1972;32:281–294
  35. Sakamoto K, Saito T, Orman R, Koizumi K, Lazar J, Salciccioli L, et al. Autonomic consequences of kainic acid-induced limbic cortical seizures in rats: peripheral autonomic nerve activity, acute cardiovascular changes, and death. Epilepsia. 2008;49:982–996
  36. Sarko J, Pollack CV. Cardiac troponins. J. Emerg. Med. 2002;23:57–65
  37. Sato K, Masuda T, Izumi T. Subarachnoid hemorrhage and myocardial damage: clinical and experimental studies. Jpn. Heart J. 1999;40:683–701
  38. Schimpf R, Veltmann C, Wolpert C, Borggrefe M. Channelopathies: brugada syndrome, long QT syndrome, and CPVT. Herz. 2009;34:281–288
  39. Schraeder PL, Lathers CM. Cardiac neural discharge and epileptogenic activity in the cat: an animals model for unexplained death. Life Sci. 1983;32:1371–1382
  40. Shimizu M, Kagawa A, Takano T, Masai H, Miwa Y. Neurogenic stunned myocardium associated with status epilepticus and postictal catecholamine surge. Intern. Med. 2008;47:269–273
  41. Shu H, Yi-Ming W, Xu LP, Miao CY, Su DF. Increased susceptibility of ventricular arrhythmias to aconitine in anaesthetized rats in attributed to the inhibition of baroreflex. Clin. Exp. Pharmacol. Physiol. 2004;31:249–253
  42. Singer AW, Jaax NK, Graham JS, McLeod CG. Cardiomyopathy in Soman and Sarin intoxicated rats. Toxicol. Lett. 1987;36:2432-2249
  43. Su T, Cong WD, Long YS, Luo AH, Sun WW, Deng WY, et al. Altered expression of voltage-gated potassium channel 4.2 and voltage-gated potassium channel 4-interacting protein, and changes in intracellular calcium levels following lithium-pilocarpine-induced status epilepticus. Neuroscience. 2008;157:566–576
  44. Tomlinson FH, Anderson RE, Meyer FB. Effect of arterial blood pressure and serum glucose on brain intracellular pH and cortical blood flow during status epilepticus in the white New Zealand rabbit. Epilepsy Res. 1993;14:123–137
  45. Towne AR, Pellock JM, Ko D, DeLorenzo RJ. Determinants of mortality in status epilepticus. Epilepsia. 1994;35:27–34
  46. Tryphonas L, Veinot JP, Clement JG. Early histopathological and ultrastructural changes in the heart of Sprague–Dawley rats following administration of soman. Toxicol. Pathol. 1996;24:190–198
  47. Ueda K, Valdivia C, Medeiros-Domingo A, Tester DJ, Vatta M, Farrugia G, et al. Syntrophin mutation associated with long QT syndrome through activation of the nNOS-SCN5A macromolecular complex. Proc. Natl. Acad. Sci. 2008;105:9355–9360
  48. Vatta M, Ackerman MJ, Ye B, Makielski JC, Ughanze EE, Taylor EW, et al. Mutant caveolin-3 induces persistent late sodium current and is associated with long-QT syndrome. Circulation. 2006;114:2104–2112
  49. Volk T, Nguyen TH-P, Schultz J-H, Faulhaber J, Ehmke H. Regional alterations of repolarizing K+ currents among the left ventricular free wall of rats with ascending aortic stenosis. J. Physiol. 2001;530:443–455
  50. Wu G, Ai T, Kim JJ, Mohapatra B, Xi Y, Li Z, et al. a-1-Syntrophin mutation and the long-QT syndrome: a disease of sodium channel disruption. Circ. Arrhythmia Electrophysiol. 2008;1:193–201
  51. Xu Z, Patel KP, Rozanski GJ. Metabolic basis of decreased outward K= current in ventricular myocytes from diabetic rats. Am. J. Physiol. 1996;271:H2190–H2196

PII: S0920-1211(10)00160-9

doi: 10.1016/j.eplepsyres.2010.06.013

Epilepsy Research
Volume 91, Issue 1 , Pages 66-73 , September 2010