Epilepsy Research
Volume 91, Issue 1 , Pages 35-38 , September 2010

Association of serotonin transporter promoter (5-HTTLPR) and intron 2 (VNTR-2) polymorphisms with treatment response in temporal lobe epilepsy

  • Hecimovic Hrvoje

      Affiliations

    • Zagreb Epilepsy Center, Department of Neurology, University Hospital, Vinogradska 29, HR-10000 Zagreb, Croatia
    • Corresponding Author InformationCorresponding author. Tel.: +385 1 3787731; fax: +385 1 3787731.
    • ,
  • Stefulj Jasminka

      Affiliations

    • Laboratory of Neurochemistry and Molecular Neurobiology, Rudjer Boskovic Institute, HR-10000 Zagreb, Croatia
    • ,
  • Cicin-Sain Lipa

      Affiliations

    • Laboratory of Neurochemistry and Molecular Neurobiology, Rudjer Boskovic Institute, HR-10000 Zagreb, Croatia
    • ,
  • Demarin Vida

      Affiliations

    • Zagreb Epilepsy Center, Department of Neurology, University Hospital, Vinogradska 29, HR-10000 Zagreb, Croatia
    • ,
  • Jernej Branimir

      Affiliations

    • Laboratory of Neurochemistry and Molecular Neurobiology, Rudjer Boskovic Institute, HR-10000 Zagreb, Croatia
    • Deceased.

Received 8 March 2010 ,Revised 25 May 2010 ,Accepted 20 June 2010.

References 

  1. Caspi A, Sugden K, Moffitt TE, Taylor A, Craig IW, Harrington H, et al. Influence of life stress on depression: moderation by a polymorphism in the 5-HTT gene. Science. 2003;301:386–389
  2. Dailey JW, Mishra PK, Ko KH, Penny JE, Jobe PC. Serotonergic abnormalities in the central nervous system of seizure-naive genetically epilepsy-prone rats. Life Sci. 1992;50:319–326
  3. De Sarro G, Di Paola ED, Aguglia U, de Sarro A. Tolerance to anticonvulsant effects of some benzodiazepines in genetically epilepsy prone rats. Pharmacol. Biochem. Behav. 1996;55:39–48
  4. Fedi M, Reutens D, Okazawa H, Andermann F, Boling W, Dubeau F, et al. Localizing value of alpha-methyl-l-tryptophan PET in intractable epilepsy of neocortical origin. Neurology. 2001;57:1629–1636
  5. Fiskerstrand CE, Lovejoy EA, Quinn JP. An inotropic polymorphic domain often associated with susceptability to affective disorders has allele dependent differential enhancer activity in embryonic stem cells. FEBS Lett. 1999;458:171–174
  6. Gilliam F, Santos J, Vahle V, Carter J, Brown K, Hecimovic H. Depression in epilepsy: ignoring clinical expression of neuronal network dysfunction?. Epilepsia. 2004;45(Suppl. 2):28–33
  7. Giovacchini G, Toczek MT, Bonwetsch R, Bagic A, Lang L, Fraser C, et al. 5-HT 1A receptors are reduced in temporal lobe epilepsy after partial-volume correction. J. Nucl. Med. 2005;46:1128–1135
  8. Graff-Guerrero A, de la Fuente-Sandoval S, Camarena B, Gomez-Martin D, Apiquian R, Fresan A, et al. Frontal and limbic metabolic differences in subjects selected according to genetic variation of the SLC6A4 gene polymorphism. Neuroimage. 2005;25:1197–1204
  9. Hasler G, Bonwetsch R, Giovacchini G, Toczek MT, Bagic A, Luckenbaugh DA, et al. 5-HT1A receptor binding in temporal lobe epilepsy patients with and without major depression. Biol. Psychiatry. 2007;62:1258–1264
  10. Hranilovic D, Schwab SG, Jernej B, Knapp M, Lerer B, Albus M, et al. Serotonin transporter gene and schizophrenia: evidence for association/linkage disequilibrium in families with affected siblings. Mol. Psychiatry. 2000;5:91–95
  11. Hranilovic D, Stefulj J, Furac I, Kubat M, Balija M, Jernej B. Serotonin transporter gene promoter (5-HTTLPR) and intron 2 (VNTR) polymorphisms in Croatian suicide victims. Biol. Psychiatry. 2003;54:884–889
  12. Hranilovic D, Stefulj J, Schwab S, Borrmann-Hassenbach M, Albus M, Jernej B, et al. Serotonin transporter promoter and intron 2 polymorphisms: relationship between allelic variants and gene expression. Biol. Psychiatry. 2004;55:1090–1094
  13. Jobe PC, Dailey JW, Wernicke JF. A noradrenergic and serotonergic hypothesis of the linkage between epilepsy and affective disorders. Crit. Rev. Neurobiol. 1999;13:317–356
  14. Kauffman MA, Consalvo D, Gonzalez-Moron D, Aguirre F, D’Alessio L, Kochen S. Serotonin transporter gene variation and refractory mesial temporal epilepsy with hippocampal sclerosis. Epilepsy Res. 2009;85:231–234
  15. Lesch KP, Bengel D, Heils A, Sabol SZ, Greenberg BD, Petri S, et al. Association of anxiety-related traits with a polymorphism in the serotonin transporter gene regulatory region. Science. 1996;274:1527–1531
  16. Lesch KP, Mossner R. Genetically driven variation in serotonin uptake: is there a link to affective spectrum, neurodevelopmental, and neurodegenerative disorders?. Biol. Psychiatry. 1998;44:179–192
  17. Lu KT, Gean PW. Endogenous serotonin inhibits epileptiform activity in rat hippocampal CA1 neurons via 5-hydroxytryptamine1A receptor activation. Neuroscience. 1998;86:729–737
  18. MacKenzie A, Quinn J. A serotonin transporter gene intron 2 polymorphic region, correlated with affective disorders, has allele-dependent differential enhancer-like properties in the mouse embryo. Proc. Natl. Acad. Sci. U.S.A. 1999;96:15251–15255
  19. Mainardi P, Leonardi A, Albano C. Potentiation of brain serotonin activity may inhibit seizures, especially in drug-resistant epilepsy. Med. Hypotheses. 2008;70:876–879
  20. Manna I, Labate A, Gambardella A, Forabosco P, La Russa A, Le Piane E, et al. Serotonin transporter gene (5-Htt): association analysis with temporal lobe epilepsy. Neurosci. Lett. 2007;421:52–56
  21. Merlet I, Ostrowsky K, Costes N, Ryvlin P, Isnard J, Faillenot I, et al. 5-HT1A receptor binding and intracerebral activity in temporal lobe epilepsy: an [18F]MPPF-PET study. Brain. 2004;127:900–913
  22. Salgado-Commissariat D, Alkadhi KA. Serotonin inhibits epileptiform discharge by activation of 5-HT1A receptors in CA1 pyramidal neurons. Neuropharmacology. 1997;36:1705–1712
  23. Statnick MA, Dailey JW, Jobe PC, Browning RA. Abnormalities in brain serotonin concentration, high-affinity uptake, and tryptophan hydroxylase activity in severe-seizure genetically epilepsy-prone rats. Epilepsia. 1996;37:311–321
  24. Theodore WH. Does serotonin play a role in epilepsy?. Epilepsy Curr. 2003;3:173–177
  25. Toczek MT, Carson RE, Lang L, Ma Y, Spanaki MV, Der MG, et al. PET imaging of 5-HT1A receptor binding in patients with temporal lobe epilepsy. Neurology. 2003;60:749–756

PII: S0920-1211(10)00155-5

doi: 10.1016/j.eplepsyres.2010.06.008

Epilepsy Research
Volume 91, Issue 1 , Pages 35-38 , September 2010

Article Tools

* Image Usage & Resolution