Epilepsy Research
Volume 88, Issue 2 , Pages 168-178 , February 2010

Functional epileptic network in left mesial temporal lobe epilepsy detected using resting fMRI

  • Victoria L. Morgan

      Affiliations

    • 1161 21st Avenue South, AA 1105 MCN, Vanderbilt University Institute of Imaging Science, Department of Radiology and Radiological Sciences, Vanderbilt University, Nashville, TN 37232-2310, USA
    • Corresponding Author InformationCorresponding author. Tel.: +1 615 343 5720; fax: +1 615 322 0734.
    • ,
  • John C. Gore

      Affiliations

    • 1161 21st Avenue South, AA 1105 MCN, Vanderbilt University Institute of Imaging Science, Department of Radiology and Radiological Sciences, Vanderbilt University, Nashville, TN 37232-2310, USA
    • Tel.: +1 615 322 8357; fax: +1 615 322 0734.
    • ,
  • Bassel Abou-Khalil

      Affiliations

    • 1161 21st Avenue South, A 0122 MCN, Epilepsy Division, Department of Neurology, Vanderbilt University, Nashville, TN 37232-2551, USA
    • Tel.: +1 615 936 0060; fax: +1 615 936 0223.

Received 20 July 2009 ,Revised 26 October 2009 ,Accepted 29 October 2009.

References 

  1. Addis DR, Moscovitch M, McAndrews MP. Consequences of hippocampal damage across the autobiographical memory network in left temporal lobe epilepsy. Brain. 2007;130:2327–2342
  2. Aghakhani Y, Kobayashi E, Bagshaw AP, Hawco C, Benar CG, Dubeau F, et al. Cortical and thalamic fMRI responses in partial epilepsy with focal and bilateral synchronous spikes. Clin. Neurophysiol. 2006;117:177–191
  3. Arnold S, Schlaug G, Niemann H, Ebner A, Luders H, Witte OW, et al. Topography of interictal glucose hypometabolism in unilateral mesiotemporal epilepsy. Neurology. 1996;46:1422–1430
  4. Bagshaw AP, Aghakhani Y, Benar CG, Kobayashi E, Hawco C, Dubeau F, et al. EEG-fMRI of focal epileptic spikes: analysis with multiple haemodynamic functions and comparison with gadolinium-enhanced MR angiograms. Hum. Brain Mapp. 2004;22:179–192
  5. Bertram EH, Mangan PS, Zhang D, Scott CA, Williamson JM. The midline thalamus: alterations and a potential role in limbic epilepsy. Epilepsia. 2001;42:967–978
  6. Bettus G, Guedj E, Joyeux F, Confort-Gouny S, Soulier E, Laguitton V, et al. Decreased basal fMRI functional connectivity in epileptogenic networks and contralateral compensatory mechanisms. Hum. Brain Mapp. 2008;30:1580–1591
  7. Bhattacharyya PK, Lowe MJ. Cardiac-induced physiologic noise in tissue is a direct observation of cardiac-induced fluctuations. Magn. Reson. Imaging. 2004;22:9–13
  8. Birn RM, Diamond JB, Smith MA, Bandettini PA. Separating respiratory-variation-related fluctuations from neuronal-activity-related fluctuations in fMRI. Neuroimage. 2006;31:1536–1548
  9. Biswal B, Yetkin FZ, Haughton VM, Hyde JS. Functional connectivity in the motor cortex of resting human brain using echo-planar MRI. Magn. Reson. Med. 1995;34:537–541
  10. Blumenfeld H, McNally KA, Vanderhill SD, Paige AL, Chung R, Davis K, et al. Positive and negative network correlations in temporal lobe epilepsy. Cereb. Cortex. 2004;14:892–902
  11. Bouilleret V, Dupont S, Spelle L, Baulac M, Samson Y, Semah F. Insular cortex involvement in mesiotemporal lobe epilepsy: a positron emission tomography study. Ann. Neurol. 2002;51:202–208
  12. Buckner RL, Andrews-Hanna JR, Schacter DL. The brain's default network: anatomy, function, and relevance to disease. Ann. N. Y. Acad. Sci. 2008;1124:1–38
  13. Chang C, Glover GH. Effects of model-based physiological noise correction on default mode network anti-correlations and correlations. Neuroimage. 2009;47:1448–1459
  14. Chassoux F, Semah F, Bouilleret V, Landre E, Devaux B, Turak B, et al. Metabolic changes and electro-clinical patterns in mesio-temporal lobe epilepsy: a correlative study. Brain. 2004;127:164–174
  15. Di Bonaventura C, Vaudano AE, Carni M, Pantano P, Nucciarelli V, Garreffa G, et al. EEG/fMRI Study of Ictal and Interictal epileptic Activity: Methodological Issues and Future Perspectives in Clinical Practice. Blackwell Publishing; 2006;pp. 52–58
  16. Dupont P, Zaknun JJ, Maes A, Tepmongkol S, Vasquez S, Bal CS, et al. Dynamic perfusion patterns in temporal lobe epilepsy. Eur. J. Nucl. Med. Mol. I. 2009;36:823–830
  17. Englot DJ, Mishra AM, Mansuripur PK, Herman P, Hyder F, Blumenfeld H. Remote effects of focal hippocampal seizures on the rat neocortex. J. Neurosci. 2008;28:9066–9081
  18. Flanagan D, Abbott DF, Jackson GD. How wrong can we be? The effect of inaccurate mark-up of EEG/fMRI studies in epilepsy. Clin. Neurophysiol. 2009;120:1637–1647
  19. Fox MD, Zhang DY, Snyder AZ, Raichle ME. The global signal and observed anticorrelated resting state brain networks. J. Neurophysiol. 2009;101:3270–3283
  20. Frings L, Schulze-Bonhage A, Spreer J, Wagner K. Reduced interhemispheric hippocampal BOLD signal coupling related to early epilepsy onset. Seizure. 2008;18:153–157
  21. Giovacchini G, Bonwetsch R, Herscovitch P, Carson RE, Theodore WH. Cerebral blood flow in temporal lobe epilepsy: a partial volume correction study. Eur. J. Nucl. Med. Mol. Imaging. 2007;34:2066–2072
  22. Gotman J, Grova C, Bagshaw A, Kobayashi E, Aghakhani Y, Dubeau F. Generalized epileptic discharges show thalamocortical activation and suspension of the default state of the brain. Proc. Natl. Acad. Sci. U.S.A. 2005;102:15236–15240
  23. Gotman J, Kobayashi E, Bagshaw AP, Benar CG, Dubeau F. Combining EEG and fMRI: a multimodal tool for epilepsy research. J. Magn. Reson. Imaging. 2006;23:906–920
  24. Guye M, Regis J, Tamura M, Wendling F, McGonigal A, Chauvel P, et al. The role of corticothalamic coupling in human temporal lobe epilepsy. Brain. 2006;129:1917–1928
  25. Hamandi K, Salek Haddadi A, Liston A, Laufs H, Fish DR, Lemieux L. fMRI temporal clustering analysis in patients with frequent interictal epileptiform discharges: comparison with EEG-driven analysis. Neuroimage. 2005;26:309–316
  26. Hetherington HP, Kuzniecky RI, Vives K, Devinsky O, Pacia S, Luciano D, et al. A subcortical network of dysfunction in TLE measured by magnetic resonance spectroscopy. Neurology. 2007;69:2256–2265
  27. Isnard J, Guenot M, Ostrowsky K, Sindou M, Mauguiere F. The role of the insular cortex in temporal lobe epilepsy. Ann. Neurol. 2000;48:614–623
  28. Jacobs J, Levan P, Moeller F, Boor R, Stephani U, Gotman J, et al. Hemodynamic changes preceding the interictal EEG spike in patients with focal epilepsy investigated using simultaneous EEG-fMRI. Neuroimage. 2009;45:1220–1231
  29. Kahn I, Andrews-Hanna JR, Vincent JL, Snyder AZ, Buckner RL. Distinct cortical anatomy linked to subregions of the medial temporal lobe revealed by intrinsic functional connectivity. J. Neurophysiol. 2008;100:129–139
  30. Kim BJ, Hong SB, Seo DW. Differences in ictal hyperperfusion of limbic-related structures between mesial temporal and neocortical epilepsy. Epilepsy Res. 2008;81:167–175
  31. Kobayashi E, Bagshaw AP, Benar CG, Aghakhani Y, Andermann F, Dubeau F, et al. Temporal and extratemporal BOLD responses to temporal lobe interictal spikes. Epilepsia. 2006;47:343–354
  32. Kobayashi E, Bagshaw AP, Grova C, Dubeau F, Gotman J. Negative BOLD responses to epileptic spikes. Hum. Brain Mapp. 2006;27:488–497
  33. Kobayashi Y, Amaral DG. Macaque monkey retrosplenial cortex: II. Cortical afferents. J. Comp. Neurol. 2003;466:48–79
  34. Labate A, Briellmann RS, Abbott DF, Waites AB, Jackson GD. Typical childhood absence seizures are associated with thalamic activation. Epileptic Disord. 2005;7:373–377
  35. Laufs H, Hamandi K, Salek-Haddadi A, Kleinschmidt AK, Duncan JS, Lemieux L. Temporal lobe interictal epileptic discharges affect cerebral activity in “Default mode” brain regions. Hum. Brain Mapp. 2007;28:1023–1032
  36. Lin JJ, Salamon N, Lee AD, Dutton RA, Geaga JA, Hayashi KM, et al. Reduced neocortical thickness and complexity mapped in mesial temporal lobe epilepsy with hippocampal sclerosis. Cereb. Cortex. 2007;17:2007–2018
  37. Liu Y, Gao JH, Liu HL, Fox PT. The temporal response of the brain after eating revealed by functional MRI. Nature. 2000;405:1058–1062
  38. McMillan AB, Hermann BP, Johnson SC, Hansen RR, Seidenberg M, Meyerand ME. Voxel-based morphometry of unilateral temporal lobe epilepsy reveals abnormalities in cerebral white matter. Neuroimage. 2004;23:167–174
  39. Morgan VL, Gore JC. Detection of irregular, transient fMRI activity in normal controls using 2dTCA: comparison to event-related analysis using known timing. Hum. Brain Mapp. 2009;30:3393–3405
  40. Morgan VL, Gore JC, Abou-Khalil B. Cluster analysis detection of functional MRI activity in temporal lobe epilepsy. Epilepsy Res. 2007;76:22–33
  41. Morgan VL, Gore JC, Szaflarski JP. Temporal clustering analysis: what does it tell us about the resting state of the brain?. Med. Sci. Monit. 2008;14:CR345–352
  42. Morgan VL, Li Y, Abou-Khalil B, Gore JC. Development of 2dTCA for the detection of irregular, transient BOLD activity. Hum. Brain Mapp. 2008;29:57–69
  43. Morgan VL, Price RR, Arain A, Modur P, Abou-Khalil B. Resting functional MRI with temporal clustering analysis for localization of epileptic activity without EEG. Neuroimage. 2004;21:473–481
  44. Murphy K, Birn RM, Handwerker DA, Jones TB, Bandettini PA. The impact of global signal regression on resting state correlations: are anti-correlated networks introduced?. Neuroimage. 2008;44:893–905
  45. Norden AD, Blumenfeld H. The role of subcortical structures in human epilepsy. Epilepsy Behav. 2002;3:219–231
  46. Raichle ME, MacLeod AM, Snyder AZ, Powers WJ, Gusnard DA, Shulman GL. A default mode of brain function. Proc. Natl. Acad. Sci. U.S.A. 2001;98:676–682
  47. Rombouts SA, Stam CJ, Kuijer JP, Scheltens P, Barkhof F. Identifying confounds to increase specificity during a “no task condition”. Evidence for hippocampal connectivity using fMRI. Neuroimage. 2003;20:1236–1245
  48. Rosenberg DS, Mauguiere F, Demarquay G, Ryvlin P, Isnard J, Fischer C, et al. Involvement of medial pulvinar thalamic nucleus in human temporal lobe seizures. Epilepsia. 2006;47:98–107
  49. Salek-Haddadi A, Diehl B, Hamandi K, Merschhemke M, Liston A, Friston K, et al. Hemodynamic correlates of epileptiform discharges: an EEG-fMRI study of 63 patients with focal epilepsy. Brain Res. 2006;1088:148–166
  50. Salek-Haddadi A, Lemieux L, Merschhemke M, Friston KJ, Duncan JS, Fish DR. Functional magnetic resonance imaging of human absence seizures. Ann. Neurol. 2003;53:663–667
  51. Tae WS, Joo EY, Kim JH, Han SJ, Suh YL, Kim BT, et al. Cerebral perfusion changes in mesial temporal lobe epilepsy: SPM analysis of ictal and interictal SPECT. Neuroimage. 2005;24:101–110
  52. Tao JX, Ray A, Hawes-Ebersole S, Ebersole JS. Intracranial EEG substrates of scalp EEG interictal spikes. Epilepsia. 2005;46:669–676
  53. Wagner K, Frings L, Halsband U, Everts R, Buller A, Spreer J, et al. Hippocampal functional connectivity reflects verbal episodic memory network integrity. Neuroreport. 2007;18:1719–1723
  54. Waites AB, Briellmann RS, Saling MM, Abbott DF, Jackson GD. Functional connectivity networks are disrupted in left temporal lobe epilepsy. Ann. Neurol. 2006;59:335–343
  55. Weissenbacher A, Kasess C, Gerstl F, Lanzenberger R, Moser E, Windischberger C. Correlations and anticorrelations in resting-state functional connectivity MRI: a quantitative comparison of preprocessing strategies. Neuroimage. 2009;47:1408–1416

PII: S0920-1211(09)00324-6

doi: 10.1016/j.eplepsyres.2009.10.018

Epilepsy Research
Volume 88, Issue 2 , Pages 168-178 , February 2010

Article Tools

* Image Usage & Resolution