Epilepsy Research
Volume 88, Issue 2 , Pages 162-167 , February 2010

Effect of intravenous immunoglobulin treatment on brain interferon-gamma and interleukin-6 levels in a rat kindling model

Received 21 April 2009 ,Revised 28 October 2009 ,Accepted 29 October 2009.

References 

  1. Akira S, Takeda K, Kaisho T. Toll-like receptors: critical proteins linking innate and acquired immunity. Nat. Immunol. 2001;2:675–680
  2. Ariizumi M, Baba K, Shiihara H, Ogawa K, Hibio S, Suzuki Y, et al. High dose gammaglobulin for intractable childhood epilepsy. Lancet. 1983;2:162–163
  3. Billiau AD, Witters P, Ceulemans B, Kasran A, Wouters C, Lagae L. Intravenous immunoglobulins in refractory childhood-onset epilepsy: effects on seizure frequency, EEG activity, and cerebrospinal fluid cytokine profile. Epilepsia. 2007;48:1739–1749
  4. Correale J, Rabinowicz AL, Heck CN, Smith TD, Loskota WJ, DeGiorgio CM. Status epilepticus increases CSF levels of neuron-specific enolase and alters the blood–brain barrier. Neurology. 1998;50:1388–1391
  5. De Sarro G, Russo E, Ferreri G, Giuseppe B, Flocco MA, Di Paola ED, et al. Seizure susceptibility to various convulsant stimuli of knockout interleukin-6 mice. Pharmacol. Biochem. Behav. 2004;77:761–766
  6. DeGiorgio CM, Gott PS, Rabinowicz AL, Heck CN, Smith TD, Correale JD. Neuron-specific enolase, a marker of acute neuronal injury, is increased in complex partial status epilepticus. Epilepsia. 2005;37:606–609
  7. Diehl RG, Smialowski A, Gotwo T. Development and persistence of kindled seizures after repeated injections of pentylenetetrazol in rats and guinea pigs. Epilepsia. 1984;25:506–510
  8. Hulse RE, Kunkler PE, Fedynyshyn JP, Kraig RP. Optimization of multiplexed bead-based cytokine immunoassays for rat serum and brain tissue. J. Neurosci. Methods. 2004;136:87–98
  9. Kalueff AV, Lehtimaki KA, Ylinen A, Honkaniemi J, Peltola J. Intranasal administration of human IL-6 increases the severity of chemically induced seizures in rats. Neurosci. Lett. 2004;365:106–110
  10. Kawakami Y, Fukunaga Y, Kuwabara K, Fujita T, Fujino O, Hashimoto K. Clinical and immunological significance of neopterin measurement in cerebrospinal fluid in patients with febrile convulsions. Brain Dev. 1999;21:458–460
  11. Lehtimäki KA, Peltola J, Koskikallio E, Keränen T, Honkaniemi J. Expression of cytokines and cytokine receptors in the rat brain after kainic acid-induced seizures. Brain Res. Mol. Brain Res. 2003;110:253–260
  12. Lehtimäki KA, Keränen T, Huhtala H, Hurme M, Ollikainen J, Honkaniemi J, et al. Regulation of IL-6 system in cerebrospinal fluid and serum compartments by seizures: the effect of seizure type and duration. J. Neuroimmunol. 2004;152:121–125
  13. Li GQ, Lin ZD, Jiao Y, Shi XL, Ye XY, Hu HW. Changes of serum and cerebrospinal fluid neuron-specific enolase. S100β and myelin basic protein levels in children with epilepsy after seizures. Chin. J. Contemp. Pediatr. 2004;6:500–503
  14. Li, X., Renzhe, A.N., 2005. Change of the production of INF-γ, IL-10 in peripheral blood mononuclear cells from convulsion rats and the influence of immunoglobulin on it. A thesis for the degree of master of pediatrics in Clinic of Yanbian University Medical College.
  15. Ling ZD, Yeoh E, Webb BT, Farrell K, Doucette J, Matheson DS. Intravenous immunoglobulin induces interferon-gamma and interleukin-6 in vivo. J. Clin. Immunol. 1993;13:302–309
  16. Marangos PJ, Schmechel D, Parma AM, Clark RL, Goodwin FK. Measurement of neuron-specific (NSE) and non-neuronal (NNE) isoenzymes of enolase in rat, monkey and human nervous tissue. J Neurochem. 1979;33:319–329
  17. Mikati MA, Shamseddine AN. Management of Landau–Kleffner syndrome. Paediatr. Drugs. 2005;7:377–389
  18. Müller M, Fontana A, Zbinden G, Gähwiler BH. Effects of interferons and hydrogen peroxide on CA3 pyramidal cells in rat hippocampal slice cultures. Brain Res. 1993;619:157–162
  19. Najjar S, Bernbaum M, Lai G, Devinsky O. Immunology and epilepsy. Rev. Neurol. Dis. 2008;5:109–116
  20. Oses JP, Leke R, Portela LV, Lara DR, Schmidt AP, Casali EA, et al. Biochemical brain markers and purinergic parameters in rat CSF after seizure induced by pentylenetetrazol. Brain Res. Bull. 2004;64:237–242
  21. Péchadre JC, Sauvezie B, Osier C, Gibert J. The treatment of epileptic encephalopathies with gamma globulin in children (author's transl.). Rev. Electroencephalogr. Neurophysiol. Clin. 1977;7:443–447In French
  22. Renzhe AN, Yan GH, Piao DM, Yin YR, Chi YX. Effects of immunoglobulin on the neuronal expression of IL-1beta and IL-1ra and the neuronal death at hippocampus in rats with convulsion induced by pentylenetetrazol. Zhonghua Er Ke Za Zhi. 2005;43:849–851(in Chinese)
  23. Royds JA, Parsons MA, Taylor CB, Timperley WR. Enolase isoenzyme distribution in the human brain and its tumours. J. Pathol. 1982;137:37–49
  24. Shiihara H, Michihiro N, Sakuta R, Saga T, Ojima K, Ariizumi M. Changes in the lymphocyte subsets during high dose immunoglobulin therapy for intractable childhood epilepsy. Psychiatry Clin. Neurosci. 1995;49:S251–S253
  25. Sternberg JM, Rodgers J, Bradley B, Maclean L, Murray M, Kennedy PG. Meningoencephalitic African trypanosomiasis: Brain IL-10 and IL-6 are associated with protection from neuro-inflammatory pathology. J. Neuroimmunol. 2005;167:81–89
  26. Turrin NP, Rivest S. Innate immune reaction in response to seizures: implications for the neuropathology associated with epilepsy. Neurobiol. Dis. 2004;16:321–334
  27. van Engelen BG, Renier WO, Weemaes CM, Gabreels FJ, Meinardi H. Immunoglobulin treatment in epilepsy, a review of the literature. Epilepsy Res. 1994;19:181–190
  28. Xiaoqin Z, Zhengli L, Changgeng Z, Xiaojing W, Li L. Changes in behavior and amino acid neurotransmitters in the brain of rats with seizure induced by IL-1beta or IL-6. J. Huazhong Univ. Sci. Technol. Med. Sci. 2005;25:236–239

PII: S0920-1211(09)00320-9

doi: 10.1016/j.eplepsyres.2009.10.014

Epilepsy Research
Volume 88, Issue 2 , Pages 162-167 , February 2010

Article Tools

* Image Usage & Resolution