Epilepsy Research
Volume 88, Issue 2 , Pages 127-138 , February 2010

Application of volumetric MR spectroscopic imaging for localization of neocortical epilepsy

  • Andrew A. Maudsley

      Affiliations

    • Department of Radiology, University of Miami School of Medicine, 1150 N.W. 14th St., Miami, FL 33136, United States
    • Corresponding Author InformationCorresponding author at: Department of Radiology, University of Miami School of Medicine, 1150 N.W. 14th St., Suite 713, Miami, FL 33136, United States. Tel.: +1 305 243 8080; fax: +1 305 243 3405.
  • ,
  • Claudia Domenig

      Affiliations

    • Department of Radiology, University of Miami School of Medicine, 1150 N.W. 14th St., Miami, FL 33136, United States
  • ,
  • R. Eugene Ramsay

      Affiliations

    • Department of Neurology, University of Miami School of Medicine, 1150 N.W. 14th St., Miami, FL 33136, United States
  • ,
  • Brian C. Bowen

      Affiliations

    • Department of Radiology, University of Miami School of Medicine, 1150 N.W. 14th St., Miami, FL 33136, United States

Received 26 June 2009 ,Revised 7 October 2009 ,Accepted 15 October 2009.

References 

  1. Collins DL, Zijdenbos AP, Kollokian V, Sled JG, Kabani NJ, Holmes CJ, et al. Design and construction of a realistic digital brain phantom. IEEE Trans. Med. Imaging. 1998;17:463–468
  2. Ebel A, Maudsley AA. Improved spectral quality for 3D MR spectroscopic imaging using a high spatial resolution acquisition strategy. Magn. Reson. Imaging. 2003;21:113–120
  3. Garcia PA, Laxer KD, van der Grond J, Hugg JW, Matson GB, Weiner MW. Correlation of seizure frequency with N-acetyl-aspartate levels determined by 1H magnetic resonance spectroscopic imaging. Magn. Reson. Imaging. 1997;15:475–478
  4. Goffin K, Dedeurwaerdere S, Van Laere K, Van Paesschen W. Neuronuclear assessment of patients with epilepsy. Semin. Nucl. Med. 2008;38:227–239
  5. Guye M, Ranjeva JP, Le Fur Y, Bartolomei F, Confort-Gouny S, Regis J, et al. 1H-MRS imaging in intractable frontal lobe epilepsies characterized by depth electrode recording. Neuroimage. 2005;26:1174–1183
  6. Hartman AL, Lesser RP. Update on epilepsy and cerebral localization. Curr. Neurol. Neurosci. Rep. 2007;7:498–507
  7. Haupt CI, Schuff N, Weiner MW, Maudsley AA. Removal of lipid artifacts in 1H spectroscopic imaging by data extrapolation. Magn. Reson. Med. 1996;35:678–687
  8. Krsek P, Hajek M, Dezortova M, Jiru F, Skoch A, Marusic P, et al. (1)H MR spectroscopic imaging in patients with MRI-negative extratemporal epilepsy: correlation with ictal onset zone and histopathology. Eur. Radiol. 2007;17:2126–2135
  9. Kuzniecky R, Devinsky O. Surgery insight: surgical management of epilepsy. Nat. Clin. Pract. Neurol. 2007;3:673–681
  10. Kuzniecky R, Hetherington H, Pan J, Hugg J, Palmer C, Gilliam F, et al. Proton spectroscopic imaging at 4.1tesla in patients with malformations of cortical development and epilepsy. Neurology. 1997;48:1018–1024
  11. Laxer KD. Clinical applications of magnetic resonance spectroscopy. Epilepsia. 1997;38(Suppl. 4):S13–S17
  12. Leite CC, Lucato LT, Sato JR, Valente KD, Otaduy MC. Multivoxel proton MR spectroscopy in malformations of cortical development. Am. J. Neuroradiol. 2007;28:1071–1075(discussion 1076–1077)
  13. Li LM, Cendes F, Andermann F, Dubeau F, Arnold DL. Spatial extent of neuronal metabolic dysfunction measured by proton MR spectroscopic imaging in patients with localization-related epilepsy. Epilepsia. 2000;41:666–674
  14. Lundbom N, Gaily E, Vuori K, Paetau R, Liukkonen E, Rajapakse JC, et al. Proton spectroscopic imaging shows abnormalities in glial and neuronal cell pools in frontal lobe epilepsy. Epilepsia. 2001;42:1507–1514
  15. Maudsley AA, Darkazanli A, Alger JR, Hall LO, Schuff N, Studholme C, et al. Comprehensive processing, display and analysis for in vivo MR spectroscopic imaging. NMR Biomed. 2006;19:492–503
  16. Maudsley AA, Domenig C, Govind V, Darkazanli A, Studholme C, Arheart K, et al. Mapping of brain metabolite distributions by volumetric proton MR spectroscopic imaging (MRSI). Magn. Reson. Med. 2009;61:548–559
  17. Maudsley AA, Domenig C, Sheriff S. Reproducibility of serial whole-brain MR spectroscopic imaging. NMR Biomed. 2009;22:1–7
  18. Maudsley AA, Studholme C, Govindaraju V. Tissue-dependent Analysis of Metabolic Alterations in the Brain by MR Spectroscopic Imaging. Toronto: International Society for Magnetic Resonance in Medicine; 2008;p. 1604
  19. Moffett JR, Ross B, Arun P, Madhavarao CN, Namboodiri AMA. N-acetylaspartate in the CNS: from neurodiagnostics to neurobiology. Prog. Neurobiol. 2007;81:89–131
  20. Mueller SG, Laxer KD, Barakos JA, Cashdollar N, Flenniken DL, Vermathen P, et al. Identification of the epileptogenic lobe in neocortical epilepsy with proton MR spectroscopic imaging. Epilepsia. 2004;45:1580–1589
  21. Mueller SG, Laxer KD, Barakos JA, Cashdollar N, Flenniken DL, Vermathen P, et al. Metabolic characteristics of cortical malformations causing epilepsy. J. Neurol. 2005;252:1082–1092
  22. Mueller SG, Laxer KD, Cashdollar N, Flenniken DL, Matson GB, Weiner MW. Identification of abnormal neuronal metabolism outside the seizure focus in temporal lobe epilepsy. Epilepsia. 2004;45:355–366
  23. Pan JW, Williamson A, Cavus I, Hetherington HP, Zaveri H, Petroff OA, et al. Neurometabolism in human epilepsy. Epilepsia. 2008;49(Suppl. 3):31–41
  24. Rousseau F, Maudsley AA, Ebel A, Darkazanli A, Weber P, Sivasankaran K, et al. Evaluation of sub-voxel registration accuracy between MRI and 3D MR spectroscopy of the brain. In: Proc Soc Photo Opt Instrum Eng 5747. San Diego. 2005;p. 1213–1221
  25. Simister RJ, McLean MA, Barker GJ, Duncan JS. Proton MR spectroscopy of metabolite concentrations in temporal lobe epilepsy and effect of temporal lobe resection. Epilepsy Res. 2009;83:168–176
  26. Smith SM, Jenkinson M, Woolrich MW, Beckmann CF, Behrens TE, Johansen-Berg H, et al. Advances in functional and structural MR image analysis and implementation as FSL. Neuroimage. 2004;23(Suppl. 1):S208–S219
  27. Soher BJ, Young K, Govindaraju V, Maudsley AA. Automated spectral analysis III: application to in vivo proton MR spectroscopy and spectroscopic imaging. Magn. Reson. Med. 1998;40:822–831
  28. Stanley JA, Cendes F, Dubeau F, Andermann F, Arnold DL. Proton magnetic resonance spectroscopic imaging in patients with extratemporal epilepsy. Epilepsia. 1998;39:267–273
  29. Studholme C, Hill DL, Hawkes DJ. Automated three-dimensional registration of magnetic resonance and positron emission tomography brain images by multiresolution optimization of voxel similarity measures. Med. Phys. 1997;24:25–35
  30. Zhang Y, Brady M, Smith S. Segmentation of brain MR images through a hidden Markov random field model and the expectation-maximization algorithm. IEEE Trans. Med. Imaging. 2001;20:45–57

PII: S0920-1211(09)00297-6

doi: 10.1016/j.eplepsyres.2009.10.009

Epilepsy Research
Volume 88, Issue 2 , Pages 127-138 , February 2010