Epilepsy Research
Volume 88, Issue 2 , Pages 108-111 , February 2010

No major clinical impact of Val66Met BDNF gene polymorphism on temporal lobe epilepsy

  • José Augusto Bragatti

      Affiliations

    • Division of Neurology, Hospital de Clinicas de Porto Alegre, Porto Alegre, Brazil
    • Corresponding Author InformationCorresponding author. Tel.: +5551 3359 8520; fax: +5551 32224690.
    • ,
  • Laila Cigana Schenkel

      Affiliations

    • Medical Genetic Service, Hospital de Clínicas de Porto Alegre, Porto Alegre, Brazil
    • ,
  • Carolina Machado Torres

      Affiliations

    • Division of Neurology, Hospital de Clinicas de Porto Alegre, Porto Alegre, Brazil
    • ,
  • Gisele Gus Manfro

      Affiliations

    • Division of Psychiatry, Hospital de Clinicas de Porto Alegre, Porto Alegre, Brazil
    • ,
  • Carolina Blaya

      Affiliations

    • Division of Psychiatry, Hospital de Clinicas de Porto Alegre, Porto Alegre, Brazil
    • ,
  • Ana Claudia de Souza

      Affiliations

    • Division of Neurology, Hospital de Clinicas de Porto Alegre, Porto Alegre, Brazil
    • ,
  • Diogo Onofre Gomes de Souza

      Affiliations

    • Department of Biochemistry, Universidade Federal do Rio Grande do Sul, Porto Alegre, Brazil
    • ,
  • Maria Luiza Saraiva-Pereira

      Affiliations

    • Medical Genetic Service, Hospital de Clínicas de Porto Alegre, Porto Alegre, Brazil
    • Department of Biochemistry, Universidade Federal do Rio Grande do Sul, Porto Alegre, Brazil
    • ,
  • Laura Bannach Jardim

      Affiliations

    • Medical Genetic Service, Hospital de Clínicas de Porto Alegre, Porto Alegre, Brazil
    • ,
  • Sandra Leistner-Segal

      Affiliations

    • Medical Genetic Service, Hospital de Clínicas de Porto Alegre, Porto Alegre, Brazil
    • ,
  • Marino Muxfeldt Bianchin

      Affiliations

    • Division of Neurology, Hospital de Clinicas de Porto Alegre, Porto Alegre, Brazil

Received 18 June 2009 ,Revised 22 August 2009 ,Accepted 4 October 2009.

References 

  1. Bath KG, Lee FS. Variant BDNF (Val66Met) impact on brain structure and function. Cogn. Affect. Behav. Neurosci. 2006;6:79–85
  2. Commission on Classification Terminology of the International League Against Epilepsy . Proposal for revised classification of epilepsies and epileptic syndromes. Epilepsia. 1989;30:389–399
  3. Egan MF, Kojima M, Callicott JH, Goldberg TE, Kolachana BS, Bertolino A, et al. The BDNF Val66Met polymorphism affects activity-dependent secretion of BDNF and human memory and hippocampal function. Cell. 2003;112:257–269
  4. Frustaci A, Pozzi G, Gianfagna F, Manzoli L, Boccia S. Meta-analysis of the brain-derived neurotrophic factor gene (BDNF) Val66Met polymorphism in anxiety disorders and anxiety-related personality traits. Neuropsychobiology. 2008;58:163–170
  5. IBGE Cidades@ [http://www.ibge.gov.br/cidadesat/default.php].
  6. Kanemoto K, Kawasaki J, Tarao Y, Kumaki T, Oshima T, Kaji R, et al. Association of partial epilepsy with brain-derived neurotrophic factor (BDNF) gene polymorphisms. Epilepsy Res. 2003;53:255–258
  7. Lohoff FW, Ferraro TN, Dahl JP, Hildebrandt MA, Scattergood TM, O’Connor MJ, et al. Lack of association between variations in the brain-derived neurotrophic factor (BDNF) gene and temporal lobe epilepsy. Epilepsy Res. 2005;66:59–62
  8. Louhivuori V, Arvio M, Soronen P, Oksanen V, Paunio T, Castrén ML. The Val66Met polymorphism in the BDNF gene is associated with epilepsy in Fragile X syndrome. Epilepsy Res. 2009;85:114–117
  9. Miller SA, Dykes DD, Polesky HF. A simple salting out procedure for extracting DNA from human nucleated cells. Nucleic Acids Res. 1988;16:1215
  10. Nectoux J, Bahi-Buisson N, Guellec I, Coste J, De Roux N, Rosas H, et al. The Val66Met polymorphism in the BDNF gene protects against early seizures in Rett syndrome. Neurology. 2008;70:2145–2151
  11. Petryshen TL, Sabeti PC, Aldinger KA, Fry B, Fan JB, Schaffner SF, et al. Population genetic study of the brain-derived neurotrophic factor (BDNF) gene. Mol. Psychiatry. 2009;Epub ahead of print
  12. Rybakowski JK. BDNF gene: functional Val66Met polymorphism in mood disorders and schizophrenia. Pharmacogenomics. 2008;9:1589–1593
  13. Shimizu E, Hashimoto K, Iyo M. Ethnic difference of the BDNF 196G/A (val66met) polymorphism frequencies: the possibility to explain ethnic mental traits. Am. J. Med. Genet. (Neuropsychiatr. Genet.). 2004;126B:122–123
  14. Schulz KF, Grimes DA. Sample size calculation in randomized trials: mandatory and mystical. Lancet. 2005;365:1348–1353

PII: S0920-1211(09)00291-5

doi: 10.1016/j.eplepsyres.2009.10.003

Epilepsy Research
Volume 88, Issue 2 , Pages 108-111 , February 2010

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