Epilepsy Research
Volume 87, Issue 1 , Pages 102-105, November 2009

Abnormal parieto-motor connectivity in Tuberous Sclerosis Complex

  • Luigi D’Argenzio

      Affiliations

    • Paediatric Neurology and Psychiatry Unit, Neuroscience Department, Tor Vergata University, Rome, Italy
    • Corresponding Author InformationCorresponding author at: Paediatric Neurology and Psychiatry Unit, Neuroscience Department, Faculty of Medicine, Tor Vergata University of Rome, via Montpellier, 1, 00133 Rome, Italy. Tel.: +39 06 20900249.
    • ,
  • Giacomo Koch

      Affiliations

    • Neurology Clinic, Neuroscience Department, Tor Vergata University, Rome, Italy
    • IRCCS Fondazione Santa Lucia, Rome, Italy
    • ,
  • Roberta Bombardieri

      Affiliations

    • Paediatric Neurology and Psychiatry Unit, Neuroscience Department, Tor Vergata University, Rome, Italy
    • ,
  • Francesco Mori

      Affiliations

    • Neurology Clinic, Neuroscience Department, Tor Vergata University, Rome, Italy
    • IRCCS Fondazione Santa Lucia, Rome, Italy
    • ,
  • Romina Moavero

      Affiliations

    • Paediatric Neurology and Psychiatry Unit, Neuroscience Department, Tor Vergata University, Rome, Italy
    • ,
  • Diego Centonze

      Affiliations

    • Neurology Clinic, Neuroscience Department, Tor Vergata University, Rome, Italy
    • IRCCS Fondazione Santa Lucia, Rome, Italy
    • ,
  • Paolo Curatolo

      Affiliations

    • Paediatric Neurology and Psychiatry Unit, Neuroscience Department, Tor Vergata University, Rome, Italy

Received 24 March 2009; received in revised form 19 June 2009; accepted 24 July 2009.

Summary 

Abnormal connectivity might be involved in the pathophysiology of Tuberous Sclerosis Complex (TSC). We used twin-coil Transcranial Magnetic Stimulation protocol to investigate connectivity between posterior parietal cortex (PPC) and motor cortex (M1) in TSC patients. In comparison with healthy subjects and TSC patients treated with antiepileptic drugs, non-medicated TSC patients exhibited abnormal excitability of PPC–M1 connection. Such altered connectivity might play a role in TSC epileptic phenotype.

Keywords: Tuberous Sclerosis Complex, Transcranial Magnetic Stimulation, Functional cortical connectivity

To access this article, please choose from the options below

Login to an existing account or Register a new account.

  • Purchase this article for 31.50 USD (You must login/register to purchase this article)

    Online access for 24 hours. The PDF version can be downloaded as your permanent record.

  • Claim access now

    For current subscribers with Society Membership or Account Number.

  • Visit SciVerse ScienceDirect to see if you have access via your institution.
 

PII: S0920-1211(09)00202-2

doi:10.1016/j.eplepsyres.2009.07.009

Epilepsy Research
Volume 87, Issue 1 , Pages 102-105, November 2009

Article Tools

* Image Usage & Resolution