Movement induces suppression of interictal spikes in sensorimotor neocortical epilepsy

Yanagisawa, Takufumi; Hirata, Masayuki; Kishima, Haruhiko; Goto, Tetsu; Saitoh, Youichi; Oshino, Satoru; Hosomi, Koichi; Kato, Amami; Yoshimine, Toshiki

doi:10.1016/j.eplepsyres.2009.07.002

« Previous Next »Epilepsy Research
Volume 87, Issue 1 , Pages 12-17, November 2009

Movement induces suppression of interictal spikes in sensorimotor neocortical epilepsy

Takufumi Yanagisawa
- Department of Neurosurgery, Osaka University Medical School, Osaka 565-0871, Japan
- ATR Computational Neuroscience Laboratories, Kyoto 619-0288, Japan
Masayuki Hirata
- Department of Neurosurgery, Osaka University Medical School, Osaka 565-0871, Japan
- Division of Functional Diagnostic Science, Osaka University Graduate School of Medicine, Osaka 565-0871, Japan
- Corresponding author at: Department of Neurosurgery, Osaka University Medical School, E6 2-2 Yamadaoka Suita, Osaka 565-0871, Japan. Tel.: +81 6 6879 3652; fax: +81 6 6879 3659.
Haruhiko Kishima
- Department of Neurosurgery, Osaka University Medical School, Osaka 565-0871, Japan
Tetsu Goto
- Department of Neurosurgery, Osaka University Medical School, Osaka 565-0871, Japan
Youichi Saitoh
- Department of Neurosurgery, Osaka University Medical School, Osaka 565-0871, Japan
Satoru Oshino
- Department of Neurosurgery, Osaka University Medical School, Osaka 565-0871, Japan
Koichi Hosomi
- Department of Neurosurgery, Osaka University Medical School, Osaka 565-0871, Japan
Amami Kato
- Department of Neurosurgery, Kinki University Medical School, Osaka, Japan
- CREST, Japan Science and Technology Agency, Tokyo, Japan
Toshiki Yoshimine
- Department of Neurosurgery, Osaka University Medical School, Osaka 565-0871, Japan

Received 28 March 2009; received in revised form 27 June 2009; accepted 11 July 2009.

Summary

Epileptic activities are known to be modulated by cortical excitability, which is altered with normal brain functioning such as movement. However, the relationship between the epileptic activity and movement has not been well studied. Here, we investigated movement-induced modulation of interictal spikes to reveal the relationship between epileptic activity and the movement-induced modulation of cortical activity. Two patients (three cases) with focal cortical dysplasia (FCD) of the pre- and/or post-central gyrus performed voluntary movements of their hands or mouths. During the movement, the interictal spikes of the sensorimotor cortex, which were measured by electrocorticograms (ECoG), were significantly reduced. This reduction strongly correlated with the event-related desynchronization (ERD) of the cortical oscillatory activity at the lower frequency bands (<25Hz) during movement. The epileptic activity was suggested to be modulated by the movement, which correlates with the ERD of the cortical oscillatory activity.