Epilepsy Research
Volume 83, Issue 1 , Pages 73-80 , January 2009

Abnormal Ca2+ mobilization in hippocampal slices of epileptic animals fed a zinc-deficient diet

Received 12 May 2008 ,Revised 24 September 2008 ,Accepted 25 September 2008.

References 

  1. Bancila V, Nikonenko I, Dunant Y, Bloc A. Zinc inhibits glutamate release via activation of pre-synaptic KATP channels and reduces ischaemic damage in rat hippocampus. J. Neurochem. 2004;90:1243–1250
  2. Buhl EH, Otis TS, Mody I. Zinc-induced collapse of augmented inhibition by GABA in a temporal lobe epilepsy model. Science. 1996;271:369–373
  3. Cavazos JE, Golarai G, Sutula TP. Mossy fiber synaptic reorganization induced by kindling: time course of development, progression, and permanence. J. Neurosci. 1991;11:2795–2803
  4. Choi DW, Koh JY. Zinc and brain injury. Annu. Rev. Neurosci. 1998;21:347–375
  5. Chu Y, Mouat MF, Harris RBS, Coffield JA, Grider A. Water maze performance and changes in serum corticosterone levels in zinc-deprived and pair-fed rats. Physiol. Behav. 2003;78:569–578
  6. Cole TB, Robbins CA, Wenzel HJ, Schwartzkroin PA, Palmiter RD. Seizures and neuronal damage in mice lacking vesicular zinc. Epilepsy Res. 2000;39:153–169
  7. Côté A, Chiasson M, Peralta MR, Lafortune K, Pellegrini L, Tóth K. Cell type-specific action of seizure-induced intracellular zinc accumulation in the rat hippocampus. J. Physiol. 2005;566:821–837
  8. Cruz SL, Gauthereau MY, Camacho-Muñoz C, López-Rubalcava C, Balster RL. Effects of inhaled toluene and 1,1,1-trichloroethane on seizures and death produced by N-methyl-d-aspartic acid in mice. Behav. Brain Res. 2003;140:195–202
  9. During MJ, Spencer DD. Extracellular hippocampal glutamate and spontaneous seizure in the conscious human brain. Lancet. 1993;341:1607–1610
  10. Elliott EM, Sapolsky RM. Corticosterone enhances kainic acid-induced calcium elevation in cultured hippocampal neurons. J. Neurochem. 1992;59:1033–1040
  11. Elliott EM, Sapolsky RM. Corticosterone impairs hippocampal neuronal calcium regulation—possible mediating mechanisms. Brain Res. 1993;602:84–90
  12. Frederickson CJ. Neurobiology of zinc and zinc-containing neurons. Int. Rev. Neurobiol. 1989;31:145–238
  13. Frederickson CJ, Danscher G. Zinc-containing neurons in hippocampus and related CNS structures. Prog. Brain Res. 1990;83:71–84
  14. Fukahori M, Itoh M. Effects of dietary zinc status on seizure susceptibility and hippocampal zinc content in the El (epilepsy) mouse. Brain Res. 1990;529:16–22
  15. Golub MS, Keen CL, Gershwin ME, Hendrickx AG. Developmental zinc deficiency and behavior. J. Nutr. 1995;125:2263–2271
  16. Klingauf J, Kavalali ET, Tsien RW. Kinetics and regulation of fast endocytosis at hippocampal synapses. Nature. 1998;394:581–585
  17. Koh JY, Suh SW, Gwag BJ, He YY, Hsu CY, Choi DW. The role of zinc in selective neuronal death after transient global cerebral ischemia. Science. 1996;272:1013–1016
  18. Lauri SE, Bortolotto ZA, Nistico R, Bleakman D, Ornstein PL, Lodge D, et al. A role for Ca2+ stores in kainate receptor-dependent synaptic facilitation and LTP at mossy fiber synapses in the hippocampus. Neuron. 2003;39:327–341
  19. Lavoie N, Peralta MR, Chiasson M, Lafortune K, Pellegrini L, Seress L, et al. Extracellular chelation of zinc does not affect hippocampal excitability and seizure-induced cell death in rats. J. Physiol. 2007;578:275–289
  20. Lee JM, Zipfel GJ, Choi DW. The changing landscape of ischaemic brain injury mechanisms. Nature. 1999;399:A7–A14
  21. Lee AL, Ogle WO, Sapolsky RM. Stress and depression: possible links to neuron death in the hippocampus. Bipolar Disord. 2002;4:117–128
  22. Marganella C, Bruno V, Matrisciano F, Reale C, Nicoletti F, Melchiorri D. Comparative effects of levobupivacaine and racemic bupivacaine on excitotoxic neuronal death in culture and N-methyl-d-aspartate-induced seizures in mice. Eur. J. Pharmacol. 2005;518:111–115
  23. McLaughlin SG, Szabo G, Eisenman G. Divalent ions and the surface potential of charged phospholipids membranes. J. Gen. Physiol. 1971;58:667–687
  24. McLaughlin A, Grathwohl C, McLaughlin S. The adsorption of divalent cations to phosphatidylcholine bilayer membranes. Biochim. Biophys. Acta. 1978;513:338–357
  25. Minami A, Sakurada N, Fuke S, Kikuchi K, Nagano T, Oku N, et al. Inhibition of presynaptic activity by zinc released from mossy fiber terminals during tetanic stimulation. J. Neurosci. Res. 2006;83:167–176
  26. Molnár P, Nadler JV. Synaptically-released zinc inhibits N-methyl-d-aspartate receptor activation at recurrent mossy fiber synapses. Brain Res. 2001;910:205–207
  27. Monaghan DT, Cotman CW. The distribution of [3H] kainic acid binding sites in rat CNS as determined by autoradiography. Brain Res. 1982;252:91–100
  28. Morimoto K, Fahnestock M, Racine RJ. Kindling and status epilepticus models of epilepsy: rewiring the brain. Prog. Neurobiol. 2004;73:1–60
  29. Pei Y, Zhao D, Huang J, Cao L. Zinc-induced seizures: a new experimental model of epilepsy. Epilepsia. 1983;24:169–176
  30. Prasad AS. Clinical srectrum and diagnostic aspects of human zinc deficiency. In:  Prasad AS editors. Essential and Toxic Trace Elements in Human Health and Disease. New York: Liss; 1988;p. 3–53
  31. Quinta-Ferreira ME, Matias CM. Hippocampal mossy fiber calcium transients are maintained during long-term potentiation and are inhibited by endogenous zinc. Brain Res. 2004;1004:52–60
  32. Quinta-Ferreira ME, Matias CM. Tetanically released zinc inhibits hippocampal mossy fiber calcium, zinc and synaptic response. Brain Res. 2005;1004:52–60
  33. Rassendren FA, Lory P, Pin JP, Nargeot J. Zinc has opposite effects on NMDA and non-NMDA receptors expressed in Xenopus oocytes. Neuron. 1990;4:733–740
  34. Rodriguez-Moreno A, Sihra TS. Presynaptic kainate receptor facilitation of glutmate release involves protein kinase A in the rat hippocampus. J. Physiol. 2004;557:733–745
  35. Schmitz D, Mellor J, Frerking M, Nicoll RA. Presynaptic kainate receptors at hippocampal mossy fiber synapses. Proc. Natl. Acad. Sci. 2001;98:11003–11008
  36. Seyfried TN, Glaser GH. A review of mouse mutants as genetic models of epilepsy. Epilepsia. 1985;26:143–150
  37. Sindreu CB, Varoqui H, Erickson JD, Perez-Clausell J. Boutons containing vesicular zinc define a subpopulation of synapses with low AMPAR content in rat hippocampus. Cereb. Cortex. 2003;13:823–829
  38. Sterman MB, Shouse MN, Fairchild MD, Belsito O. Kindled seizure induction alters and is altered by zinc absorption. Brain Res. 1986;383:382–386
  39. Sterman MB, Shouse MN, Fairchild MD. Zinc and seizure mechanisms. In:  Morley JE,  Sterman MB,  Walsh JH editor. Nutritional Modulation of Neural Function. San Diego: Academic Press; 1988;p. 307–319
  40. Suh SW, Garnier P, Aoyama K, Chen Y, Swanson RA. Zinc release contributes to hypoglycemia-induced neuronal death. Neurobiol. Dis. 2004;16:538–545
  41. Sutula T, He XX, Cavazos J, Scott G. Synaptic reorganization in the hippocampus induced abnormal functional activity. Science. 1998;239:1147–1150
  42. Takeda A. Zinc homeostasis and functions of zinc in the brain. Biometals. 2001;14:343–352
  43. Takeda A. Essenttial trace metals and brain function. Yakugaku Zasshi. 2004;124:577–585
  44. Takeda A, Minami A, Takefuta S, Tochigi M, Oku N. Zinc homeostasis in the brain of adult rats fed zinc-deficient diet. J. Neurosci. Res. 2001;63:447–452
  45. Takeda A, Hirate M, Tamano H, Nishibaba D, Oku N. Susceptibility to kainate-induced seizures under dietary zinc deficiency. J. Neurochem. 2003;85:1575–1580
  46. Takeda A, Hirate M, Tamano H, Oku N. Release of glutamate and GABA in the hippocampus under zinc deficiency. J. Neurosci. Res. 2003;72:537–542
  47. Takeda A, Minami A, Seki Y, Oku N. Differential effects of zinc on glutamatergic and GABAergic neurotransmitter systems in the hippocampus. J. Neurosci. Res. 2004;75:225–229
  48. Takeda A, Tamano H, Nagayoshi A, Yamada K, Oku N. Increase in hippocampal cell death after treatment with kainate in zinc deficiency. Neurochem. Int. 2005;47:539–544
  49. Takeda A, Yamada K, Minami A, Nagano T, Oku N. Enhanced excitability of hippocampal mossy fibers and CA3 neurons under dietary zinc deficiency. Epilepsy Res. 2005;63:77–84
  50. Takeda A, Fuke S, Minami A, Oku N. Role of zinc influx via AMPA/kainate receptor activation in metabotropic glutamate receptor-mediated calcium release. J. Neurosci. Res. 2007;85:1310–1317
  51. Takeda A, Minami A, Sakurada N, Nakajima S, Oku N. Response of hippocampal mossy fiber zinc to excessive glutamate release. Neurochem. Int. 2007;50:322–327
  52. Tauck DL, Nadler JV. Evidence of functional mossy fiber sprouting in hippocampal formation of kainic acid-treated rats. J. Neurosci. 1985;5:1016–1022
  53. Vallee BL, Falchuk KH. The biological basis of zinc physiology. Physiol. Rev. 1993;73:79–118
  54. Vogt K, Mellor J, Tong G, Nicoll R. The actions of synaptically released zinc at hippocampal mossy fiber synapses. Neuron. 2000;26:187–196
  55. Weiss JH, Sensi SL, Koh JY. Zn(2+): a novel ionic mediator of neural injury in brain disease. Trends Pharmacol. Sci. 2000;21:395–401
  56. Westbrook GL, Mayer ML. Micromolar concentrations of Zn2+ antagonize NMDA and GABA responses of hippocampal neurons. Nature. 1987;328:640–643
  57. Williamson A, Spencer D. Zinc reduces dentate granule cell hyperexcitability in epileptic humans. Neuroreport. 1995;6:1562–1564
  58. Xie X, Smart TG. A physiological role for endogeneous zinc in rat hippocampal synaptic neurotransmission. Nature. 1991;349:521–524
  59. Zakharenko SS, Zablow L, Siegelbaum SA. Visualization of changes in presynaptic function during long-term synaptic plasticity. Nat. Neurosci. 2001;4:711–717

PII: S0920-1211(08)00282-9

doi: 10.1016/j.eplepsyres.2008.09.009

Epilepsy Research
Volume 83, Issue 1 , Pages 73-80 , January 2009

Article Tools

* Image Usage & Resolution