Epilepsy Research
Volume 83, Issue 1 , Pages 66-72, January 2009

Carisbamate, a novel neuromodulator, inhibits voltage-gated sodium channels and action potential firing of rat hippocampal neurons

  • Yi Liu

      Affiliations

    • Analgesics Drug Discovery, Johnson & Johnson Pharmaceutical Research & Development, L.L.C., Welsh & McKean Roads, P.O. Box 776, Spring House, PA 19477-0776, United States
    • Corresponding Author InformationCorresponding author. Tel.: +1 215 628 5427; fax: +1 215 628 3297.
    • ,
  • George J. Yohrling

      Affiliations

    • CNS Drug Discovery, Johnson & Johnson Pharmaceutical Research & Development, L.L.C., Welsh & McKean Roads, P.O. Box 776, Spring House, PA 19477-0776, United States
    • ,
  • Yan Wang

      Affiliations

    • Analgesics Drug Discovery, Johnson & Johnson Pharmaceutical Research & Development, L.L.C., Welsh & McKean Roads, P.O. Box 776, Spring House, PA 19477-0776, United States
    • ,
  • Tasha L. Hutchinson

      Affiliations

    • Analgesics Drug Discovery, Johnson & Johnson Pharmaceutical Research & Development, L.L.C., Welsh & McKean Roads, P.O. Box 776, Spring House, PA 19477-0776, United States
    • ,
  • Douglas E. Brenneman

      Affiliations

    • CNS Drug Discovery, Johnson & Johnson Pharmaceutical Research & Development, L.L.C., Welsh & McKean Roads, P.O. Box 776, Spring House, PA 19477-0776, United States
    • ,
  • Christopher M. Flores

      Affiliations

    • Analgesics Drug Discovery, Johnson & Johnson Pharmaceutical Research & Development, L.L.C., Welsh & McKean Roads, P.O. Box 776, Spring House, PA 19477-0776, United States
    • ,
  • Boyu Zhao

      Affiliations

    • CNS Drug Discovery, Johnson & Johnson Pharmaceutical Research & Development, L.L.C., Welsh & McKean Roads, P.O. Box 776, Spring House, PA 19477-0776, United States

Received 28 April 2008; received in revised form 18 September 2008; accepted 23 September 2008.

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PII: S0920-1211(08)00277-5

doi:10.1016/j.eplepsyres.2008.09.006

Epilepsy Research
Volume 83, Issue 1 , Pages 66-72, January 2009

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