Epilepsy Research
Volume 79, Issue 1 , Pages 78-83 , March 2008

Temporal pattern of oxcarbazepine and phenytoin withdrawal seizures during epilepsy monitoring

  • Nabil J. Azar

      Affiliations

    • Department of Neurology, Vanderbilt University Medical Center, A-0118 MCN 2551, Nashville, TN 37232-2551, United States
    • ,
  • Lily Wang

      Affiliations

    • Department of Biostatistics, Vanderbilt University Medical Center, A-0118 MCN 2551, Nashville, TN 37232-2551, United States
    • ,
  • Yanna Song

      Affiliations

    • Department of Biostatistics, Vanderbilt University Medical Center, A-0118 MCN 2551, Nashville, TN 37232-2551, United States
    • ,
  • Bassel W. Abou-Khalil

      Affiliations

    • Department of Neurology, Vanderbilt University Medical Center, A-0118 MCN 2551, Nashville, TN 37232-2551, United States
    • Corresponding Author InformationCorresponding author. Tel.: +1 615 936 2591; fax: +1 615 936 0223.

Received 24 October 2007 ,Revised 6 December 2007 ,Accepted 29 December 2007.

References 

  1. Azar, N., Wright, A., Wang, L., Song, Y., Abou-Khalil, B., in press. Generalized tonic–clonic seizures after acute oxcarbazepine withdrawal. Neurology.
  2. Bromfield EB, Dambrosia J, Devinsky O, Nice FJ, Theodore WH. Phenytoin withdrawal and seizure frequency. Neurology. 1989;39:905–909
  3. Chadwick D. Does withdrawal of different antiepileptic drugs have different effects on seizure recurrence? Further results from the MRC antiepileptic drug withdrawal study. Brain. 1999;122(Pt 3):441–448
  4. DeToledo JC, Ramsay RE, Lowe MR, Greiner M, Garofalo EA. Increased seizures after discontinuing carbamazepine: results from the gabapentin monotherapy trial. Ther. Drug Monit. 2000;22:753–756
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  9. Malow BA, Blaxton TA, Stertz B, Theodore WH. Carbamazepine withdrawal: effects of taper rate on seizure frequency. Neurology. 1993;43:2280–2284
  10. Malow BA, Lynch B, Blaxton TA, Mikati MA. Relationship of carbamazepine reduction rate to seizure frequency during inpatient telemetry. Epilepsia. 1994;35:1160–1164
  11. Marciani MG, Gotman J, Andermann F, Olivier A. Patterns of seizure activation after withdrawal of antiepileptic medication. Neurology. 1985;35:1537–1543
  12. Marks DA, Katz A, Scheyer R, Spencer SS. Clinical and electrographic effects of acute anticonvulsant withdrawal in epileptic patients. Neurology. 1991;41:508–512
  13. May TW, Korn-Merker E, Rambeck B. Clinical pharmacokinetics of oxcarbazepine. Clin. Pharmacokinet. 2003;42:1023–1042
  14. Wang-Tilz Y, Tilz C, Wang B, Pauli E, Koebnick C, Stefan H. Changes of seizures activity during rapid withdrawal of lamotrigine. Eur. J. Neurol. 2005;12:280–288
  15. Zhou D, Wang Y, Hopp P, Kerling F, Kirchner A, Pauli E, et al. Influence on ictal seizure semiology of rapid withdrawal of carbamazepine and valproate in monotherapy. Epilepsia. 2002;43:386–393

PII: S0920-1211(08)00010-7

doi: 10.1016/j.eplepsyres.2007.12.014

Epilepsy Research
Volume 79, Issue 1 , Pages 78-83 , March 2008

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