Epilepsy Research
Volume 77, Issue 2 , Pages 93-101 , December 2007

Voxel-based morphometry in the detection of dysplasia and neoplasia in childhood epilepsy: Combined grey/white matter analysis augments detection

  • Jason M. Bruggemann

      Affiliations

    • Sydney Children's Hospital & University of New South Wales, Randwick, New South Wales, Australia
  • ,
  • Marko Wilke

      Affiliations

    • University Children's Hospital, Tuebingen, Germany
  • ,
  • Seu S. Som

      Affiliations

    • Sydney Children's Hospital & University of New South Wales, Randwick, New South Wales, Australia
  • ,
  • Ann M.E. Bye

      Affiliations

    • Sydney Children's Hospital & University of New South Wales, Randwick, New South Wales, Australia
  • ,
  • Andrew Bleasel

      Affiliations

    • Children's Hospital Westmead, Westmead, NSW, Australia
  • ,
  • John A. Lawson

      Affiliations

    • Sydney Children's Hospital & University of New South Wales, Randwick, New South Wales, Australia
    • Corresponding Author InformationCorresponding author at: Department of Neurology, Sydney Children's Hospital, High Street, Randwick, NSW 2031, Australia. Tel.: +61 2 93821658; fax: +61 2 93821580.

Received 17 March 2007 ,Revised 21 July 2007 ,Accepted 13 September 2007.

References 

  1. Ashburner J, Friston KJ. Voxel-based morphometry—the methods. Neuroimage. 2000;11(6 Pt 1):805–821
  2. Ashburner J, Friston KJ. Why voxel-based morphometry should be used. Neuroimage. 2001;14(6):1238–1243
  3. Bernasconi N, Duchesne S, Janke A, Lerch J, Collins DL, Bernasconi A. Whole-brain voxel-based statistical analysis of gray matter and white matter in temporal lobe epilepsy. Neuroimage. 2004;23(2):717–723
  4. Betting LE, Mory SB, Li LM, Lopes-Cendes I, Guerreiro MM, Guerreiro CAM, et al. Voxel-based morphometry in patients with idiopathic generalized epilepsies. Neuroimage. 2006;32(2):498–502
  5. Bonilha L, Montenegro MA, Rorden C, Castellano G, Guerreiro MM, Cendes F, et al. Voxel-based morphometry reveals excess gray matter concentration in patients with focal cortical dysplasia. Epilepsia. 2006;47(5):908–915
  6. Bonilha L, Rorden C, Appenzeller S, Carolina Coan A, Cendes F, Min Li L. Gray matter atrophy associated with duration of temporal lobe epilepsy. Neuroimage. 2006;32(3):1070–1079
  7. Bonilha L, Rorden C, Castellano G, Cendes F, Li LM. Voxel-based morphometry of the thalamus in patients with refractory medial temporal lobe epilepsy. Neuroimage. 2005;25(3):1016–1021
  8. Bonilha L, Rorden C, Halford JJ, Eckert M, Appenzeller S, Cendes F, et al. Asymmetrical extra-hippocampal grey matter loss related to hippocampal atrophy in patients with medial temporal lobe epilepsy. J. Neurol. Neurosurg. Psychiatry. 2007;78(3):286–294
  9. Cascino GD. Advances in neuroimaging: surgical localization. Epilepsia. 2001;42(1):3–12
  10. Chan CHP, Briellmann RS, Pell GS, Scheffer IE, Abbott DF, Jackson GD. Thalamic atrophy in childhood absence epilepsy. Epilepsia. 2006;47(2):399–405
  11. Chassoux F, Devaux B, Landre E, Turak B, Nataf F, Varlet P, et al. Stereoelectroencephalography in focal cortical dysplasia: a 3D approach to delineating the dysplastic cortex. Brain. 2000;123(8):1733–1751
  12. Colliot O, Antel SB, Naessens VB, Bernasconi N, Bernasconi A. In vivo profiling of focal cortical dysplasia on high-resolution MRI with computational models. Epilepsia. 2006;47(1):134–142
  13. Colliot O, Bernasconi N, Khalili N, Antel SB, Naessens V, Bernasconi A. Individual voxel-based analysis of gray matter in focal cortical dysplasia. Neuroimage. 2006;29(1):162–171
  14. Cormack F, Gadian DG, Vargha-Khadem F, Cross JH, Connelly A, Baldeweg T. Extra-hippocampal grey matter density abnormalities in paediatric mesial temporal sclerosis. Neuroimage. 2005;27(3):635–643
  15. Duzel E, Schiltz K, Solbach T, Peschel T, Baldeweg T, Kaufmann J, et al. Hippocampal atrophy in temporal lobe epilepsy is correlated with limbic systems atrophy. J. Neurol. 2006;253(3):294–300
  16. Francione S, Vigliano P, Tassi L, Cardinale F, Mai R, Russo GL, et al. Surgery for drug resistant partial epilepsy in children with focal cortical dysplasia: anatomical–clinical correlations and neurophysiological data in 10 patients. J. Neurol. Neurosurg. Psychiatry. 2003;74(11):1493–1501
  17. Friston KJ, Holmes AP, Price CJ, Buchel C, Worsley KJ. Multisubject fMRI studies and conjunction analyses. Neuroimage. 1999;10(4):385–396
  18. Friston KJ, Penny WD, Glaser DE. Conjunction revisited. Neuroimage. 2005;25(3):661–667
  19. Genovese CR, Lazar NA, Nichols T. Thresholding of statistical maps in functional neuroimaging using the false discovery rate. Neuroimage. 2002;15(4):870–878
  20. Gitelman DR, Ashburner J, Friston KJ, Tyler LK, Price CJ. Voxel-based morphometry of herpes simplex encephalitis. Neuroimage. 2001;13(4):623–631
  21. Gomez-Anson B, Thom M, Moran N, Stevens J, Scaravilli F. Imaging and radiological–pathological correlation in histologically proven cases of focal cortical dysplasia and other glial and neuronoglial malformative lesions in adults. Neuroradiology. 2000;42(3):157–167
  22. Good CD, Johnsrude IS, Ashburner J, Henson RN, Friston KJ, Frackowiak RS. A voxel-based morphometric study of ageing in 465 normal adult human brains. Neuroimage. 2001;14(1 Pt 1):21–36
  23. Hamiwka L, Jayakar P, Resnick T, Morrison G, Ragheb J, Dean P, et al. Surgery for epilepsy due to cortical malformations: ten-year follow-up. Epilepsia. 2005;46(4):556–560
  24. Huppertz H-J, Grimm C, Fauser S, Kassubek J, Mader I, Hochmuth A, et al. Enhanced visualization of blurred gray–white matter junctions in focal cortical dysplasia by voxel-based 3D MRI analysis. Epilepsy Res. 2005;67(1–2):35–50
  25. ILAE . Proposal for revised classification of epilepsies and epileptic syndromes. Epilepsia. 1989;30:389–399
  26. Kassubek J, Huppertz H-J, Spreer J, Schulze-Bonhage A. Detection and localization of focal cortical dysplasia by voxel-based 3-D MRI analysis. Epilepsia. 2002;43(6):596–602
  27. Keller SS, Wieshmann UC, Mackay CE, Denby CE, Webb J, Roberts N. Voxel based morphometry of grey matter abnormalities in patients with medically intractable temporal lobe epilepsy: effects of side of seizure onset and epilepsy duration. J. Neurol. Neurosurg. Psychiatry. 2002;73(6):648–655
  28. Keller SS, Wilke M, Wieshmann UC, Sluming VA, Roberts N. Comparison of standard and optimized voxel-based morphometry for analysis of brain changes associated with temporal lobe epilepsy. Neuroimage. 2004;23(3):860–868
  29. Khajavi K, Comair YG, Wyllie E, Palmer J, Morris HH, Hahn JF. Surgical management of pediatric tumor-associated epilepsy. J. Child Neurol. 1999;14(1):15–25
  30. Koepp MJ, Woermann FG. Imaging structure and function in refractory focal epilepsy. Lancet Neurol. 2005;4(1):42–53
  31. Lawson JA, Birchansky S, Pacheco E, Jayakar P, Resnick TJ, Dean P, et al. Distinct clinicopathologic subtypes of cortical dysplasia of Taylor. Neurology. 2005;64(1):55–61
  32. Lawson JA, Nguyen W, Bleasel AF, Pereira JK, Vogrin S, Cook MJ, et al. ILAE-defined epilepsy syndromes in children: correlation with quantitative MRI. Epilepsia. 1998;39(12):1345–1349
  33. Mackay MT, Becker LE, Chuang SH, Otsubo H, Chuang NA, Rutka J, et al. Malformations of cortical development with balloon cells: clinical and radiologic correlates. Neurology. 2003;60(4):580–587
  34. McMillan AB, Hermann BP, Johnson SC, Hansen RR, Seidenberg M, Meyerand ME. Voxel-based morphometry of unilateral temporal lobe epilepsy reveals abnormalities in cerebral white matter. Neuroimage. 2004;23(1):167–174
  35. Mechelli A, Price CJ, Friston KJ, Ashburner J. Voxel-based morphometry of the human brain: methods and applications. Curr. Med. Imaging Rev. 2005;1(2):105–113
  36. Mehta S, Grabowski TJ, Trivedi Y, Damasio H. Evaluation of voxel-based morphometry for focal lesion detection in individuals. Neuroimage. 2003;20(3):1438–1454
  37. Merschhemke M, Mitchell TN, Free SL, Hammers A, Kinton L, Siddiqui A, et al. Quantitative MRI detects abnormalities in relatives of patients with epilepsy and malformations of cortical development. Neuroimage. 2003;18(3):642–649
  38. Mueller SG, Laxer KD, Cashdollar N, Buckley S, Paul C, Weiner MW. Voxel-based optimized morphometry (VBM) of gray and white matter in temporal lobe epilepsy (TLE) with and without mesial temporal sclerosis. Epilepsia. 2006;47(5):900–907
  39. Nichols T, Brett M, Andersson J, Wager T, Poline J-B. Valid conjunction inference with the minimum statistic. Neuroimage. 2005;25(3):653–660
  40. Palmini A, Gambardella A, Andermann F, Dubeau F, Costa JCd, Donatella AO, et al. Intrinsic epileptogenicity of human dysplastic cortex as suggested by corticography and surgical results. Ann. Neurol. 1995;37(4):476–487
  41. Palmini A, Najm I, Avanzini G, Babb T, Guerrini R, Foldvary-Schaefer N, et al. Terminology and classification of the cortical dysplasias. Neurology. 2004;62(6_suppl_3):S2–S8
  42. Price S, Paviour D, Scahill R, Stevens J, Rossor M, Lees A, et al. Voxel-based morphometry detects patterns of atrophy that help differentiate progressive supranuclear palsy and Parkinson's disease. Neuroimage. 2004;23(2):663–669
  43. Raymond AA, Fish DR, Sisodiya SM, Alsanjari N, Stevens JM, Shorvon SD. Abnormalities of gyration, heterotopias, tuberous sclerosis, focal cortical dysplasia, microdysgenesis, dysembryoplastic neuroepithelial tumour and dysgenesis of the archicortex in epilepsy: clinical EEG and neuroimaging features in 100 adult patients. Brain. 1995;118(3):629–660
  44. Robb RA. Biomedical Imaging, Visualisation and Analysis. New York: Wiley; 1999;
  45. Salmenpera TM, Symms MR, Rugg-Gunn FJ, Boulby PA, Free SL, Barker GJ, et al. Evaluation of Quantitative Magnetic Resonance Imaging Contrasts in MRI-Negative Refractory Focal Epilepsy. Epilepsia. 2007;48(2):229–237
  46. Tassi L, Colombo N, Garbelli R, Francione S, Lo Russo G, Mai R, et al. Focal cortical dysplasia: neuropathological subtypes, EEG, neuroimaging and surgical outcome. Brain. 2002;125(8):1719–1732
  47. Tassi L, Pasquier B, Minotti L, Garbelli R, Kahane P, Benabid AL, et al. Cortical dysplasia: electroclinical, imaging, and neuropathologic study of 13 patients. Epilepsia. 2001;42(9):1112–1123
  48. Thieben MJ, Duggins AJ, Good CD, Gomes L, Mahant N, Richards F, et al. The distribution of structural neuropathology in pre-clinical Huntington's disease. Brain. 2002;125(Pt 8):1815–1828
  49. Wiest R, Kassubek J, Schindler K, Loher TJ, Kiefer C, Mariani L, et al. Comparison of voxel-based 3-D MRI analysis and subtraction ictal SPECT coregistered to MRI in focal epilepsy. Epilepsy Res. 2005;65(1/2):125–133
  50. Wilke M, Kassubek J, Ziyeh S, Schulze-Bonhage A, Huppertz HJ. Automated detection of gray matter malformations using optimized voxel-based morphometry: a systematic approach. Neuroimage. 2003;20(1):330–343
  51. Wilke M, Schmithorst VJ, Holland SK. Assessment of spatial normalization of whole-brain magnetic resonance images in children. Hum. Brain Mapp. 2002;17(1):48–60
  52. Wilke M, Schmithorst VJ, Holland SK. Normative pediatric brain data for spatial normalization and segmentation differs from standard adult data. Magn. Reson. Med. 2003;50(4):749–757
  53. Woermann FG, Free SL, Koepp MJ, Ashburner J, Duncan JS. Voxel-by-voxel comparison of automatically segmented cerebral gray matter—a rater-independent comparison of structural MRI in patients with epilepsy. Neuroimage. 1999;10(4):373–384
  54. Woermann FG, Free SL, Koepp MJ, Sisodiya SM, Duncan JS. Abnormal cerebral structure in juvenile myoclonic epilepsy demonstrated with voxel-based analysis of MRI. Brain. 1999;122(Pt 11):2101–2108
  55. Woo CL, Chuang SH, Becker LE, Jay V, Otsubo H, Rutka JT, et al. Radiologic–pathologic correlation in focal cortical dysplasia and hemimegalencephaly in 18 children. Pediatr. Neurol. 2001;25(4):295–303

PII: S0920-1211(07)00274-4

doi: 10.1016/j.eplepsyres.2007.09.004

Epilepsy Research
Volume 77, Issue 2 , Pages 93-101 , December 2007