Epilepsy Research
Volume 24, Issue 2 , Pages 79-90 , June 1996

Modification of kainate-induced behavioral and electrographic seizures following inhibition of nitric oxide synthase in mice

  • R.Duncan Kirkby

      Affiliations

    • Corresponding Author InformationCorresponding author. Fax: + 1 (301) 402 2871
    • Neuronal Excitability Section, Epilepsy Research Branch, National Institute of Neurological Disorders and Stroke, National Institutes of Health, 10/5C205, 9000 Rockville Pike, Bethesda, MD 20892-1408, USA
    • ,
  • Robert A. Forbes

      Affiliations

    • Department of Anesthesiology, Uniformed Services University of the Health Sciences, 4301 Jones Bridge Road, Bethesda, MD 20810, USA
    • ,
  • Swaminathan Subramaniam

      Affiliations

    • Neuronal Excitability Section, Epilepsy Research Branch, National Institute of Neurological Disorders and Stroke, National Institutes of Health, 10/5C205, 9000 Rockville Pike, Bethesda, MD 20892-1408, USA
    • Present address: Dr. Reddy's Research Foundation, Bollaram Road, Miyapur, Hyderabad 500 138, India. Phone +91 (40) 285 439; Fax: + 91 (40) 285 438

Received 15 September 1995 ,Revised 15 December 1995 ,Accepted 10 January 1996.

References 

  1. Bagetta G, Ianonne M, Scorsa AM, Nistico G. Tacrine-induced seizures and brain damage in LiCl-treated rats can be prevented by Nω-nitro-l-arginine methyl ester. Eur. J. Pharmacol. 1992;213:301–304
  2. Ben-Ari Y, Tremblay DR, Ghilini G, Naquet R. Electrographic, clinical and pathological alterations following systemic administration of kainic acid, bicuculline or pentylenetetrazole: metabolic mapping using the dexoyglucose method with special reference to the pathology of epilepsy. Neuroscience. 1981;6:1361–1391
  3. Browning RA, Nelson DK. Modification of electroshock and pentylenetetrazol seizure patterns in rats after precollicular transections. Exp. Neurol. 1986;93:546–556
  4. Buisson A, Lakhmeche N, Verrecchia C, Plotkine M, Boulu RG. Nitric oxide: an endogenous anticonvulsant. NeuroReport. 1993;4:444–446
  5. Dawson VL, Dawson TL, London ED, Bredt DH, Snyder SH. Nitric oxide mediates glutamate toxicity in primary cortical cultures. In: 2nd Ed.. Proc. Natl. Acad. Sci. USA. 88:1991;p. 6368–6371
  6. De Sarro GB, Donato Di Paola E, De Sarro A, Vidal MJ. Role of nitric oxide in the genesis of excitatory amino acid-induced seizures from the deep prepiriform cortex. Fund. Clin. Pharmacol. 1991;5:503–511
  7. De Sarro GB, Donato Di Paola E, De Sarro A, Vidal MJ. l-Arginine potentiates excitatory amino acid-induced seizures elicited in the deep prepiriform cortex. Eur. J. Pharmacol. 1993;230:151–158
  8. Dev KK, Morris BJ. Modulation of α-amino-3-hydroxy-5-methyl-isoxazole-4-propionic acid (AMPA) binding sites by nitric oxide. J. Neurochem. 1994;63:946–952
  9. Guevera-Guzman R, Emson PC, Kendrick KM. Modulation of in vivo striatal transmitter release by nitric oxide and cyclic GMP. J. Neurochem. 1994;62:807–810
  10. Haberny KA, Pou S, Eccles CU. Potentiation of quinolinate-induced hippocampal lesions by inhibition of NO synthesis. Neurosci. Lett. 1992;146:187–190
  11. Laird HE, Jobe PC. The genetically epilepsy-prone rat. In:  Jobe PC,  Laird HE editor. Neurotransmitters and Epilepsy. Clifton, NJ: Humana Press; 1987;p. 57–94
  12. Lothman EW, Collins RC. Kainic acid-induced limbic seizures: metabolic, behavioral, electrographic and neuropathological correlates. Brain Res. 1981;218:299–318
  13. Manzoni O, Prezeau L, Deshager S, Sahuquet A, Sladeczek F, Bockaert JL, et al. Sodium nitroprusside blocks NMDA receptors via formation of ferro-cyanide ions. NeuroReport. 1992;3:77–80
  14. Manzoni O, Prezeau L, Marin P, Deshager S, Bockaert JL, Fagni L. Nitric oxide-induced blockade of NMDA receptors. Neuron. 1992;8:653–662
  15. Mollace V, Bagetta G, Nistico G. Evidence that l-arginine possesses proconvulsant effects mediated through nitric oxide. NeuroReport. 1991;2:269–272
  16. Moore PK, Babbedge RC, Wallace P, Gaffen ZA, Hart SL. 7-Nitro indazole, an inhibitor of nitric oxide synthase, exhibits anti-nociceptive activity in the mouse without increasing blood pressure. Br. J. Pharmacol. 1993;108:296–297
  17. Mulsch A, Busse R, Mordvintcev PI, Vanin A, Nielsen EO, Scheel-Kruger J, et al. Nitric oxide promotes seizure activity in kainate-treated rats. NeuroReport. 1994;5:2325–2328
  18. Naritoku DK, Mecozzi LB, Aiello MT, Faingold CL. Repetition of audiogenic seizures in genetically epilepsy-prone rats induces cortical epileptiform activity and additional seizure behaviors. Exp. Neurol. 1992;115:317–324
  19. O'Dell TJ, Hawkins RD, Kandel ER, Arancio O. Tests of the roles of two diffusible substances in long-term potentiation. In: 2nd Ed.. Proc. Natl. Acad. Sci. USA. 88:1991;p. 11285–11289
  20. Osonoe K, Mori N, Suzuki K, Osonoe M. Antiepileptic effects of inhibitors of nitric oxide synthase examined in pentylenetetrazol-induced seizures in rats. Brain Res. 1994;663:338–340
  21. Penix LP, Davis W, Subramaniam S. Inhibition of NO synthase increases the severity of kainic acid-induced seizures in rodents. Epilepsy Res. 1994;18:177–184
  22. Przegalinski E, Baran L, Siwanowicz J. The role of nitric oxide in kainate-induced seizures in mice. Neurosci. Lett. 1994;170:74–76
  23. Racine RJ. Modification of seizure activity by electrical stimulation. II. Motor Seizure. Electroenceph. Clin. Neurophysiol. 1972;32:281–294
  24. Ribak CE, Khurana V, Lien NT. The effect of midbrain collicular knife cuts on audiogenic seizures severity in the genetically epilepsy-prone rat. J. Hirnforsch. 1994;35:303–311
  25. Rigaud-Monnet A-S, Pinard E, Borredon J, Seylaz J. Blockade of nitric oxide synthesis inhibits hippocampal hyperemia in kainic acid-induced seizures. J. Cereb. Blood Flow Metab. 1994;14:581–590
  26. Rondouin G, Bockaert J, Lerner-Natoli M. l-Nitroarginine, an inhibitor of NO synthase, dramatically worsens limbic epilepsy in rats. NeuroReport. 1993;4:1187–1190
  27. Rondouin G, Lerner-Natoli M, Manzoni O, Lafon-Cazal M, Bockaert J. A nitric oxide (NO) synthase inhibitor accelerates amygdala kindling. NeuroReport. 1992;3:805–808
  28. Slotnick BM, Leonard CM. A stereotaxic atlas of the mouse forebrain. Rockville: US Department of Health, Education, and Welfare; 1975;
  29. Starr MS, Starr BS. Paradoxical facilitation of pilocarpine-induced seizures in the mouse by MK-801 and the nitric oxide synthesis inhibitor L-NAME. Pharmacol. Biochem. Behav. 1993;45:321–325
  30. Wada JA, Sato M. Effects of unilateral lesions in the midbrain reticular formation on kindled amygdaloid convulsions in cats. Epilepsia. 1975;16:693–697
  31. Wang Q, Theard MA, Pellegrino DA, Baughman VL, Hoffman WE, Albrecht RF, et al. Nitric oxide (NO) is an endogenous anticonvulsant but not a mediator of the increase in cerebral blood flow accompanying bicuculline-induced seizures in rats. Brain Res. 1994;658:192–198

☆ This represents the views of the authors and does not necessarily reflect those of The United States, Uniformed Services University of the Health Sciences, or the Department of Defense.

PII: 0920-1211(96)00003-4

Epilepsy Research
Volume 24, Issue 2 , Pages 79-90 , June 1996

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