Epilepsy Research
Volume 24, Issue 2 , Pages 73-77 , June 1996

Topiramate: a potent anticonvulsant in the amygdala-kindled rat

  • Albert Wauquier

      Affiliations

    • Corresponding Author InformationCorresponding author. Tel.: +1 (806) 743 2720; Fax: +1 (806) 743 1668.
    • Department of Neurology, Texas Tech University Health Sciences Center, 3601 4th Street, Lubbock, TX 79430, USA
    • ,
  • Shangdan Zhou

      Affiliations

    • Department of Neurology, Medical College of Ohio, 3000 Arlington Avenue, Toledo, OH 43699-0008, USA

Received 8 June 1995 ,Accepted 28 July 1995.

References 

  1. Albertson TE, Peterson SL, Skork L. Anticonvulsant drugs and their antagonism in kindled amygdaloid seizures in rats. Neuropharmacology. 1980;19:643–652
  2. Albright PS, Burnham WM. Development of a new pharmacological seizure model: effects of anticonvulsants on cortical and amygdala-kindled seizures in the rat. Epilepsia. 1980;21:681–689
  3. Ashton D, Wauquier A. Behavioral analysis of the effects of 15 anticonvulsants in the amygdaloid kindled rat. Psychopharmacology. 1979;55:7–13
  4. Racine RJ. Modification of seizure activity by electrical stimulation: II. Motor seizures. Electroencephalogr. Clin. Neurophysiol. 1972;32:281–294
  5. Sato M, Racine RJ, McIntyre DC. Kindling: basic mechanisms and clinical validity. Electroencephalogr. Clin. Neurophysiol. 1990;76:459–472
  6. Shank RP, Vaught JL, Gardocki JF, Coralie BD, Schupsky JJ, Raffa RB, et al. Topiramate: preclinical evaluation of a structurally novel anticonvulsant. Epilepsia. 1993;35:450–460
  7. Paxinos G, Watson C. The Rat Brain in Stereotaxic Coordinates. New York, NY: Academic Press; 1982;
  8. Tallarida RJ, Murray RB. In: 2nd Ed.. Manual of Pharmacological Calculations with Computer Programs. New York, NY: Springer; 1987;
  9. Tietz EJ, Rosenberg HC, Chiu TH. A comparison of the effects of 1,4 and 1,5 benzodiazepines in the amygdala-kindled rat and their effect on motor impairment. Epilepsy Res. 1990;3:31–40
  10. Wauquier A, Ashton D, Melis W. Behavioral analysis of amygdaloid kindling in the beagle dog and the effects of clonazepam, phenobarbital, diphenylhydantoin and flunarizine on seizure manifestation. Exp. Neurol. 1979;64:579–586

PII: 0920-1211(95)00105-0

Epilepsy Research
Volume 24, Issue 2 , Pages 73-77 , June 1996

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