Epilepsy Research
Volume 24, Issue 2 , Pages 65-72 , June 1996

Chronic and single administration of pentylenetetrazol modifies benzodiazepine receptor-binding: an autoradiographic study

  • L. Rocha

      Affiliations

    • Corresponding Author InformationCorresponding author.
    • Instituto Mexicano de Psiquiatría, División de Neurociencias, Avenida México-Xochimilco 101, CP 14370, México, DF, Mexico
    • ,
  • R.F. Ackermann

      Affiliations

    • Brain Research Institute, University of California at Los Angeles, Los Angeles, CA, USA
    • Department of Neurology, University of California at Los Angeles, Los Angeles, CA, USA
    • ,
  • J. Engel Jr.

      Affiliations

    • Department of Neurology, University of California at Los Angeles, Los Angeles, CA, USA
    • Department of Anatomy and Cell Biology, University of California at Los Angeles, Los Angeles, CA, USA

Received 11 January 1995 ,Accepted 6 July 1995.

References 

  1. Corda MG, Giorgi O, Longoni B, Orlandi M, Biggio G. Decrease in the function of the gamma-aminobutyric acid-coupled chloride channel produced by repeated administration of pentylenetetrazol to rats. J. Neurochem. 1990;55:1216–1221
  2. Corda MG, Orlandi M, Lecca D, Carboni G, Frau V, Giorgi O. Pentylenetrazol-induced kindling in rats: effect of GABA function inhibitors. Pharmacol. Biochem. Behav. 1991;40:329–333
  3. Corda MG, Orlandi M, Giorgi O. Decrease in GABAA receptor function induced by pentylenetetrazol kindling in the rat: role of N-methyl-D-aspartate (NMDA) receptors. In:  Biggio G, et al. editor. GABAergic Synaptic Transmission. New York, NY: Raven; 1992;p. 235–247
  4. Corda MG, Orlandi M, Lecca D, Giorgi O. Decrease in GABAergic function induced by pentylenetetrazol kindling in rats: antagonism by MK-801. J. Pharmacol. Exp. Ther. 1992;262:792–800
  5. Diehl RG, Smialowski A, Gotwo T. Development and persistence of kindled seizures after repeated injections of pentylenetetrazol in rats and guinea pigs. Epilepsia. 1984;25:506–510
  6. Giorgi O, Orlandi M, Geic M, Corda MG. MK-801 prevents the decrease in 35S-TBPS binding in the rat cerebral cortex induced by pentylenetetrazol kindling. Brain Res. Bull. 1991;27:835–837
  7. Goddard GV, McIntyre DC, Leech CK. A permanent change in brain function resulting from daily electrical stimulation. Exp. Neurol. 1969;25:295–330
  8. Golarai G, Cavazos JE, Sututla TP. Activation of the dentate gyrus by pentylenetetrazol evoked seizures induces mossy fiber synaptic reorganization. Brain Res. 1992;593:257–264
  9. Greenlee DV, Van Ness PC, Olsen RW. Endogenous inhibitor of GABA binding in mammalian brain. Life Sci. 1978;22:1653–1662
  10. Halonen T, Pitkanen A, Partanen J, Hyttinen JM, Riekkinen PJ. Amino acid levels in cerebrospinal fluid of rats after administration of pentylenetetrazol. Comp. Biochem. Physiol. 1992;101:21–25
  11. Hantraye P, Brouillet E, Guibert B, Chavoix C, Fukuda H, Prenant C, et al. Pentylenetetrazol-induced seizure is not mediated by benzodiazepine receptors in vivo. Neuropharmacology. 1987;26:1509–1512
  12. Ito M, Chiu TH, Rosenberg HC. Effects of pentylenetetrazol on GABA-A/benzodiazepine/picrotoxinin receptor complexes in rat brain regions. Neurochem. Res. 1986;11:637–646
  13. Ito T, Hori M, Yoshida K, Shimuzu M. Effect of anticonvulsant on seizure developing in the course of daily administration of pentetrazol to rats. Eur. J. Pharmacol. 1977;45:165–172
  14. Macdonald RL, Barker JL. Pentylenetetrazol and penicillin are selective antagonists of GABA-mediated postsynaptic inhibition in cultured mammalian neurons. Nature. 1977;267:720–721
  15. Marangos PJ, Paul SM, Parma AM, Goodwin FK, Syapin P, Skolnick P. Purinergic inhibition of diazepam binding to rat brain (in vitro). Life Sci. 1979;24:851–858
  16. Mason CR, Cooper RM. A permanent change in convulsive threshold in normal and brain-damaged rats with repeated small doses of pentylenetetrazol. Epilepsia. 1972;13:663–674
  17. Mirski MA, McKeon AC, Ferrendelli JA. Anterior thalamus and substantia nigra: two distinct structures mediating experimental generalized seizures. Brain Res. 1986;397:377–380
  18. Napias C, Bergman MO, Van Ness PC, Greenlee DV, Olsen RW. GABA binding in mammalian brain: inhibition by endogenous GABA. Life Sci. 1980;27:1001–1011
  19. Nobrega JN, Kish SJ, McIntyre-Burnham W. Autoradiographic analysis of benzodiazepine binding in entorhinal-kindled rat brains. Brain Res. 1989;498:315–322
  20. Okada R, Negishi N, Nagaya H. The role of the nigrotegmental GABAergic pathway in the propagation of pentylenetetrazol-induced seizures. Brain Res. 1989;480:383–387
  21. Olsen RW, Wamsley JK, Lee RJ, Lomax P. Benzodiazepine/barbiturate/GABA receptor-chloride ionophore complex in a genetic model for generalized epilepsy. Adv. Neurol. 1986;44:365–378
  22. Palacios JM, Young WS, Kuhar MJ. Autoradiographic localization of gamma-aminobutyric acid (GABA) receptors in rats cerebellum. In: 2nd Ed.. Proc. Natl. Acad. Sci. USA. 77:1980;p. 670–674
  23. Paul SM, Skolnick P. Rapid changes in brain benzodiazepine receptors after experimental seizures. Science. 1978;202:892–893
  24. Paxinos G, Watson C. In:  Paxinos G editors. The rat brain in stereotaxic coordinates. London, UK: Academic Press; 1986;
  25. Ramanjaneyulu R, Ticku MK. Interactions of pentamethylenetetrazole and tetrazole analogues with the picrotoxin site of the benzodiazepine-GABA receptor-ionophore complex. Eur. J. Pharmacol. 1984;98:337–345
  26. Rehavi M, Skolnick P, Paul S. Effects of tetrazole derivatives on [3H]diazepam binding in vitro: correlation with convulsant potency. Eur. J. Pharmacol. 1982;78:353–356
  27. Rocha L, Engel J, Ackermann RF, Chugani HT. Chronic pretreatment with naloxone modifies benzodiazepine receptor binding in amygdaloid kindled rats. Epilepsy Res. 1994;17:135–142
  28. Schunzel G, Wolf G, Pomrenke U, Pomrenke C, Schmidt W. Pentylenetetrazol kindling and factors of glutamate transmitter metabolism in rat hippocampus. Neuroscience. 1992;49:365–371
  29. Shin C, Pederson HB, McNamara JO. Gamma-aminobutyric acid and benzodiazepine receptors in the kindling model of epilepsy: a quantitative radiohistochemical study. J. Neurosci. 1985;5:2696–2701
  30. Sierra-Paredes G, Soto-Otero R, Mendez-Alvarez E, Galan-Valiente J, Aguilar-Veiga E, Sierra-Marcuno G. Experimental spike- and -wave discharge induced by pentylenetetrazol and tolerance to repeated injections: an electrophysiological and biochemical study. Epilepsy Res. 1989;4:139–146
  31. Stelzer A, Slater NT, ten Bruggencate G. Activation of NMDA receptors bloks GABAergic inhibition in an in vitro model of epilepsy. Nature. 1987;326:698–701
  32. Sutula T, Xiao-Xian H, Cavazos J, Scott G. Synaptic reorganization in the hippocampus induced by anormal functional activity. Science. 1988;239:1147–1150
  33. Syapin PJ, Rickman DW. Benzodiazepine receptor increase following repeated pentylenetetrazole injections. Eur. J. Pharmacol. 1981;72:117–120
  34. Tallman JF, Thomas JW, Gallager DW. GABAergic modulation of benzodiazepine binding site sensitivity. Nature. 1978;274:383–385
  35. Tietz EI, Rosenberg HC, Chiu TH. Autoradiographic localization of benzodiazepine receptor downregulation. J. Pharmacol. Exp. Ther. 1986;236:284–292
  36. Tuff LP, Racine RJ, Adamec R. The effects of kindling on GABA-mediated inhibition in the dentate gyrus of the rat. I. Paired-pulse depression. Brain Res. 1983;277:79–90
  37. Unnerstall JR, Niehoff DL, Kuhar MJ, Palacios JM. Quantitative receptor autoradiography using [3H]ultrafilm: application to multiple benzodiazepine receptors. J. Neurosci. Methods. 1982;6:59–73
  38. Vohland HW, Koransky W. Effect of alfa-hexachlorocyclohexane on metabolism and excretion of pentetrazol (cardiazol) in the rat. Naunyn Schmiedeberg's Arch. Pharmacol. 1972;273:99–108
  39. Zhang H, Rosenberg HC, Tietz EI. Injection of benzodiazepines but not GABA or muscimol into pars reticulata of substantia nigra suppresses pentylenetetrazol seizures. Brain Res. 1989;488:73–79

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Epilepsy Research
Volume 24, Issue 2 , Pages 65-72 , June 1996

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