Epilepsy Research
Volume 24, Issue 2 , Pages 65-72, June 1996

Chronic and single administration of pentylenetetrazol modifies benzodiazepine receptor-binding: an autoradiographic study

  • L. Rocha

      Affiliations

    • Corresponding Author InformationCorresponding author.
    • Instituto Mexicano de Psiquiatría, División de Neurociencias, Avenida México-Xochimilco 101, CP 14370, México, DF, Mexico
    • ,
  • R.F. Ackermann

      Affiliations

    • Brain Research Institute, University of California at Los Angeles, Los Angeles, CA, USA
    • Department of Neurology, University of California at Los Angeles, Los Angeles, CA, USA
    • ,
  • J. Engel Jr.

      Affiliations

    • Department of Neurology, University of California at Los Angeles, Los Angeles, CA, USA
    • Department of Anatomy and Cell Biology, University of California at Los Angeles, Los Angeles, CA, USA

Received 11 January 1995; accepted 6 July 1995.

Abstract 

Benzodiazepine (BDZ) receptor-binding changes in the rat brain induced by pentylentetrazol (PTZ) were investigated by in vitro autoradiography. Our experiments revealed that a single PTZ administration produced BDZ-binding decrease in cingulate, frontal, temporal, parietal and piriform cortices; caudate putamen; medial, basolateral and cortical amygdaloid nuclei; medial, ventromedial and ventroposterior thalamic nuclei; substantia nigra pars compacta and periaqueductal gray. Fully kindled rats with chronic PTZ treatment showed reduced BDZ receptor-binding in cingulate, frontal, parietal and piriform cortices; caudate putamen; medial, ventromedial and ventroposterior thalamic nuclei; and periaqueductal gray. These effects resulted from decrease in the binding capacity. Our results support that PTZ-induced chemical kindling may be associated with significant changes of the GABAergic systems and BDZ-binding from the first administration.

Keywords:  Chemical kindling, Pentylenetetrazol, Benzodiazepine receptor, GABA

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PII: 0920-1211(95)00104-2

Epilepsy Research
Volume 24, Issue 2 , Pages 65-72, June 1996

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